Austenite 계 내식강의 Creep 거동에 미치는 탄화물의 영향에 관한 연구

이형곤,이경섭 대한금속재료학회 1987 대한금속재료학회 학술대회 개요집 Vol.1987 No.1

Supply Chain 최적화 문제의 Model Management System의 설계 및 구현

이형곤,양영철,박진우 대한산업공학회 2002 대한산업공학회 춘계학술대회논문집 Vol.2002 No.5

다단계 부호화 및 복호화에 적합한 대역 분할 부호화 ( Subband Coding for Cascaded Encoder and Decoder )

이형곤,최정현,김덕규 대한전자공학회 1993 대한전자공학회 학술대회 Vol.1993 No.1

ICT융합벤처기업 임직원들의 직무특성과 직무스트레스가 직무만족에 미치는 영향 -사회적지원의 조절효과를 중심으로-

이형곤,양해술 한국디지털정책학회 2016 디지털융복합연구 Vol.14 No.9

The purpose of study was to test the effects of job characteristics and job stress on job satisfaction in the ICT Convergence Venture Companies and the moderating role of social support between job characteristics and job satisfaction. For this study, the data were collected from 15 ICT Convergence Ventures in metropolitan area by using structured questionnaires. The sample of 301 employees was selected and analyzed by hierarchical regression technique. The results showed that job characteristics had a positive effect on job satisfaction and job stress had a negative effect. And also found out social support had the moderate roles between job stress and job satisfaction except coworker support with regard to role ambiguity, whereas it did not serve as a moderate role between job characteristics and job satisfaction. The research results are summarized, the implications for ICT convergence Ventures were discussed, and the directions for future research were suggested. 본 연구의 목적은 ICT(Information and Communications Technology, 정보통신기술)를 기반으로 다양한 융복합 기술, 제품 및 서비스 사업을 영위하고 있는 ICT융합벤처기업의 임직원들을 대상으로 직무특성 및 직무스트레스가 직무만족에 미치는 영향관계와 이에 대한 사회적 지원의 조절변수 역할을 탐구하는 데 있었다. 본 연구의 자료는 구조화된 질문지를 이용하여 수집하였고, 수도권 소재 15개 ICT융합벤처기업의 임직원 301명이 최종 표본으로 확정되었다. 단계적 회귀분석방법을 사용하여 자료를 분석한 결과, ICT융합벤처기업 임직원의 직무특성 3요인은 직무만족에 유의미한 정(+)의 영향을 미치고, 직무스트레스 2요인은 직무만족에 유의미한 부(-)의 영향을 미치는 것으로 나타났다. 직무특성과 직무만족간의 영향관계에 있어 사회적 지원은 모두 유의한 조절효과를 나타내지 않은 반면, 직무스트레스와 직무만족간의 영향관계에 대해서는 유의한 조절효과를 나타내었다. 단, 역할모호성에 대한 동료의 지원은 유의하지 않게 나타났다. 이상의 연구결과를 요약하고 ICT융합벤처기업에 대한 시사점을 논의한 후, 향후 연구방향을 제시하였다.

Synergistic anti-allodynic effect between intraperitoneal thalidomide and morphine on rat spinal nerve ligation-induced neuropathic pain

이형곤,김웅모,윤명하,A Reum Park,최정일 대한마취통증의학회 2013 Korean Journal of Anesthesiology Vol.65 No.4

Background: Thalidomide has been recognized as having an anti-allodynic effect against neuropathic pain induced by spinal nerve ligation. Its clinical beneficial effects are mainly derived from its immune-modulating property, which is known to influence the analgesic action of morphine. The possible characteristics of systemic interactions between thalidomide and morphine in the context of spinal nerve ligation-induced neuropathic pain were examined in rats. Methods: Neuropathic pain was induced by ligation of the L5/6 spinal nerves in male Sprague-Dawley rats and mechanical allodynia was assessed using von Frey filaments. The ED50 was calculated for thalidomide and for morphine, and the mixture of both drugs was intraperitoneally administered at different doses of ED50 of each drug (1/8, 1/4, 1/2, 1/1 of ED50) to obtain the experimental ED50 value for the combination of thalidomide and morphine. Isobolographic analysis was used to evaluate the characteristics of drug interactions between morphine and thalidomide. Results: The ED50 of thalidomide was three-fold higher than that of morphine. The experimental ED50 value of the mixture of thalidomide and morphine was significantly lower than the calculated theoretical ED50 value. Isobolographic analysis revealed a synergistic interaction for anti-allodynic effect after intraperitoneal delivery of the thalidomide-morphine mixture. Conclusions: These results suggest that thalidomide acts synergistically with morphine to produce an anti-allodynic effect in neuropathic pain induced by spinal nerve ligation in rats. Thus, the combination of thalidomide with morphine may be one of the useful strategies in the management of neuropathic pain.

Effects of PP-g-SAN on Mechanical and Morphological Properities of PP/ABS biends

이형곤,한미선,김용수,김우년 한국고분자학회 2007 한국고분자학회 학술대회 연구논문 초록집 Vol.2007 No.4

Roles of Adenosine and Serotonin Receptors on the Antinociception of Sildenafil in the Spinal Cord of Rats

이형곤,김웅모,박천희,윤명하 연세대학교의과대학 2010 Yonsei medical journal Vol.51 No.6

Purpose: The phosphodiesterase 5 inhibitor sildenafil has antinociceptive effects,mediated by an increase in cGMP. This study examined the role of spinal adenosine and serotonin receptors played in the antinociceptive effects of intrathecal sildenafil. Materials and Methods: Intrathecal catheters were inserted into the subarachnoid space of Sprague-Dawley male rats as a drug delivery device. Pain was induced by injecting formalin into the plantar surface of rats and observing nociceptive behavior (flinching response) for 60 mininutes. Then, the effects of intrathecal adenosine and serotonin receptor antagonists on the antinociceptive activity of intrathecal sildenafil were examined. Results: Intrathecal sildenafil suppressed the flinching response in a dose-dependent manner during phases 1 and 2 in the formalin test. Both CGS 15943 and dihydroergocristine decreased the antinociceptive effects of sildenafil during phases 1 and 2 in the formalin test. Conclusion: Intrathecal sildenafil effectively attenuated the pain evoked by formalin injection. Both adenosine and serotonin receptors may be involved in the antinociceptive action of sildenafil at the spinal level.

[해외대학 산업공학과] MIT LMP(Lab. for Manufacturing & Productivity)

이형곤 대한산업공학회 2008 ie 매거진 Vol.15 No.3

백서의 간실질내 각종 조영제의 주입후 간조직손상에 관한 병리조직학적 연구

이형곤 대한영상의학회 1995 대한영상의학회지 Vol.32 No.2

Purpose: To evaluate the severity of tissue necrosis of liver according to various kinds of contrast materialused in percutaneous transhepatic procedure. Materials and Methods: Four kinds of commercially available contrastmaterial were used in the this study: meglumine ioxithalamate (ionic monomer, Telebrix 30, Guerbet, France),meglumine ioglicinate (ionic dimer, Rayvist 300, Schering, Germany), iopromide (nonionic monomer, Ultravist 300,Schering, Germany), and iotrolan (nonionic dimer, Isovist 300, Schering, Germany). The same amount(0.1ml) of eachcontrast material was directly injected into the liver of Sprague-Dawley rats. After two days and four weeks, thehistopathologic findings of resected liver were assessed and analysed with special emphasis on the difference inthe area of tissue necrosis between each group. Results: In liver resected 48 hours later, the area of necrosiswas related to the osmolality and ionicity of contrast material used: the higher the osmolality, the wider thearea of necrosis and ionic contrast material exhibited wider area of necrosis than nonionic contrast material. Inthe liver resected four weeks later, almost complete recovery was seen at the site of necrosis in all groups.Conclusion: Nonionic contrast materials caused less tissue necrosis than ionic contrast materials in percutaneoustranshepatic procedure because of their lower osmolality.

수평열의 해부학적 형태에 관한 연구

이형곤 대한영상의학회 1993 대한영상의학회지 Vol.29 No.4

The minor fissure is an important anatomical landmark in the localization of the pulmonary diseases, For the evaluation of the normal feature of the minor fissure, we analyzed the high-resolution computed tomography (CT) scans in 51 normal patients. The purposes of this study are to evaluate the normal appearance of the minor fissure on high-resolution CT scans and to compare it with that on the coventional cT and chest radio-graphs. We analysed the morphologic feature of the minor fissure on the high-resolution CT scans in 51 nor-mal patients, and compared it with that on the conventional CT scans. On the high-resolution CT scans, we particularly paid attention to the completeness and types according to Berkmen classification. And finally, we compared the types determined by the high-resolution CT scans with those by the plain radiographs. In most patients (n=47), the minor fissure was seen as a hyperattenuating line or band on the high-resolution CT scans. In contrast, it was mostly seen as a lucent zone on the conventional CT scans (n=44) Of 47 patients having a hyperattenuating line or band on the high resolution CT scans, the minor fissure was considered to be complete in 17 patients (36%), and incomplete in 30 patients (64%), who had a defect at medial portion of the minor fissure. The most common type of the minor fissure seen on the high-resolution CT scans was type I variety (n=23), followed by type IIa(n=10) and type IIa(n=10) and type II (n=8). We could not determine the type in six patients. The type determined by the high resolution CT scans was highly well correlated with that determined by the plain radiographs (p<0.05). In conclusion, the minor fissure was seen on CT studies as variable appearances and high-resolution CT scans were superior to the conventonal cT scans in the evaluation of the minor fissure, The types of the minor fissure determined by the high-resolution CT scans were well correlated with those seen on the radiographs.