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여재익,함휘찬,김용현,육승근 한국생산제조학회 2019 한국생산제조학회지 Vol.28 No.6
A microjet with a velocity of approximately 140 m/s and 150 μm diameter is injected into a narrow nozzle by a pressure wave delivered by laser-induced bubble expansion. The driving force of such an injector is a discontinuous pulse of a 10 Hz period. Every time a pulse ends, unnecessary air bubbles are introduced into the injector due to the decrease in its internal pressure. Such air bubbles interfere with the flow inside the injector, deteriorating its performance. Therefore, we developed a nozzle closure that reacts automatically to the driving force with a pulse shape. When the flow occurs, the nozzle is opened; when it does not, the nozzle is closed to prevent unnecessary air inflow. In this study, a microjet injector was applied to needle-free drug injection. We compared and analyzed the drug penetration performance of the injector with and without the nozzle closure attached to the injector.