2007년부터 2009년까지 제2종돈능력검정소 검정돈의 불합격 요인 분석

유창열 ( Chang Yeul Yoo ),이후장 ( Hu Jang Lee ) 한국예방수의학회(구 한국수의공중보건학회) 2011 예방수의학회지 Vol.35 No.1

This study was carried out to investigate the distribution of disqualified boars tested on performance at the Second Korea Swine Testing Station from 2007 to 2009. Data used in this study were 6,758 records of Duroc, Landrace and Yorkshire breeding stocks which were registered in the herd book of the Korea Animal Improvement Association. Duroc breeding stocks tested performance were vastly outnumbered by Landrace and Yorkshire breeding stocks tested on performance. In disqualifying boars tested on performance, the Yorkshire was the most breeding stock. In the disqualifying factor in 2007, the shortage of index was the most factor. And the most of the disqualifying factors in 2008 and 2009 was the excess of daily age as reaching with 90㎏body weight.

LC-MS/MS를 이용한 우유 중 덱사메타손의 잔류 분석법 개발

차춘남,박은기,유창열,이성중,손송이,김석,이후장,Cha, Chun-Nam,Park, Eun-Kee,Yoo, Chang-Yeul,Lee, Sung Joong,Son, Song-Ee,Kim, Suk,Lee, Hu-Jang 한국식품위생안전성학회 2017 한국식품위생안전성학회지 Vol.32 No.5

본 연구는 우유 중에서 덱사메타손을 효과적으로 정량분석하기 위한 LC-MS/MS법을 확립하고 이를 검증하기 위해 수행되었다. 확립된 LC-MS/MS에 대해 특이성, 검출한계, 정량한계, 정확도 및 정밀도에 대한 검증을 통하여 유효성을 확인하였다. 표준용액을 이용하여 검량성을 작성한 결과, $r^2$ > 0.999 이상의 직선성을 확인하였고, 덱사메타손에 대한 검출한계와 정량한계는 각각 0.15와 0.5 ng/mL이었다. 또한, 회수율은 98.9-109.6%로 나타났으며, 상대표준편차는 1.7-4.4%로 나타나 정확성이 우수하였으며, 이는 식품의약품안전처의 잔류동물용의약품 분석법에서 제시한 기준에 모두 적합한 수준이었다. 따라서 본 연구를 통해 개발된 LC-MS/MS법은 향후 우유 중 덱사메타손을 분석하는데 효과적으로 활용될 수 있을 것으로 사료된다. An analytical method for the determination of dexamethasone (DM) in bovine milk samples was developed and validated using liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS). Milk samples were extracted by the liquid-liquid extraction based on acetonitrile. The chromatographic separation was achieved on a reverse phase $C_{18}$ column with gradient elution using a mobile phase of 0.1% formic acid in 95% acetonitrile. The procedure was validated according to the Ministry of Food and Drug Safety guideline determining accuracy, precision, limit of detection (LOD), and limit of quantification (LOQ). Mean recoveries of DM from spiked milk samples (25, 125, and 1,250 ng/mL) were 98.9-109.6%, and the relative standard deviation was between 1.7 and 4.4%. Linearity in concentration range of 12.5-1,250 ng/mL was obtained with the correlation coefficient ($r^2$) of 0.9997. LOD and LOQ for the investigated DM were 0.15 and 0.5 ng/mL depending on milk samples, respectively. This method was reliable, sensitive, economical and suitable for routine monitoring of DM residues in bovine milk.

JPEG2000 이미지에서 적응적 코드블록 판별 알고리즘을 이용한 동적 고속 관심영역 코딩 방법

강기준,서영건,박재흥,유창열,박순화,이점숙,이부권,Kang, Ki-Jun,Seo, Yeong-Geon,Park, Jae-Heung,Yoo, Chang-Yeul,Park, Soon-Hwa,Lee, Jum-Suk,Lee, Bu-Kwon 한국정보처리학회 2007 정보처리학회논문지B Vol.14 No.5

본 논문에서는 묵시적 ROI 코딩 방법과 수정된 묵시적 ROI 코딩 방법을 보완한 JPEG2000 이미지에서 적응적 코드블록 판별 알고리즘을 이용한 동적 고속 관심영역 코딩 방법을 제안한다. 제안한 방법에서는 코드 블록 판별 시간을 줄이기 위하여 ROI 모양의 특징을 고려하여 몇 가지의 경계 모양을 만들고, 이 모양 패턴으로 한정하여 코드블록 판별 알고리즘을 만들었다. 그리고 ROI 임계값과 배경 임계값을 이용하여 ROI 코드블록 내의 배경 웨이블릿 계수의 포함율에 따라 적응적인 코드블록 판별을 함으로서 ROI 코드블록 내의 배경 웨이블릿 계수의 우선적 처리와 손실 문제를 개선하였다. 또한 ROI 코드블록 내의 배경 웨이블릿 계수의 우선권 조절은 웨이블릿 계수 단위로 처리하는 기존의 방법과는 달리 패턴을 기반으로 하여 일괄처리를 함으로서 빠른 ROI 코딩이 가능하다. 제안한 방법의 유용성을 보이기 위해 기존의 방법들과 비교 실험한 결과, 제안한 방법이 기존의 방법들과 성능 평가에 있어서 큰 차이가 없으면서 처리 속도는 매우 빠름을 확인하였다. In this paper, we propose a fast and dynamic Region-of-Interest coding method using the adaptive code-block discrimination algorithm in JPEG2000 images which complements the implicit ROI coding method and the modified implicit ROI coding method. For reducing the time of discriminating the code block, the proposed method estimates the characteristics of the shape of ROI and makes the shape of boundaries, and classifies the patterns of each code block. The method improves the preferred processing and loss of wavelet coefficients of background within the ROI code blocks by adaptively classifying the code blocks with the percentage of content of the wavelet coefficients using the thresholds of ROI and background. Also, the priority control of wavelet coefficients of background within ROI code block supports the rapid ROI coding by processing in batch based on patterns unlike the existing methods that process with unit of wavelet coefficients. To show the usefulness of this method, we compared this to the existing methods. There is no difference in performance, but we confirmed very speedy in processing time.

초기하분포 소프트웨어 신뢰성 성장 모델 ; 일반화 , 추정과 예측

박중양(Park Joong Yang),유창열(Yoo Chang Yeul),박재흥(Park Jae Heung) 한국정보처리학회 1999 정보처리학회논문지 Vol.6 No.9

The hyper-geometric distribution software reliability growth model (HGDM) was recently developed and successfully applied to real data sets. The HGDM considers the sensitivity factor as a parameter to be estimated. In order to reflect the random behavior of the test-and-debug process, this paper generalizes the HGDM by assuming that the sensitivity factor is a binomial random variable. Such a generalization enables us to easily understand the statistical characteristics of the HGDM. It is shown that the least squares method produces the identical results for both the HGDM and the generalized HGDM. Methods for computing the maximum likelihood estimates and predicting the future outcomes are also presented.

초기하분포 소프트웨어 신뢰성 성장 모델에서의 무수 추정과 예측 방법

박중양(Park Joong Yang),유창열(Yoo Chang Yeul),이부권(Lee Bu Kwon) 한국정보처리학회 1998 정보처리학회논문지 Vol.5 No.9

The hyper-geometric distribution software reliability growth model was recently developed and successfully applied. Due to mathematical difficulty of the maximum likelihood method, the least squares method has been suggested for parameter estimation by the previous studies. We first summarize and compare the minimization criteria adopted by the previous studies. It is then shown that the weighted least squares method is more appropriate because of the nonhomogeneous variability of the number of newly detected faults. The adequacy of the weighted least squares method is illustrated by two numerical examples. Finally, we propose a new method for predicting the number of faults newly discovered by next test instances. The new prediction method can be used for determining the time to stop testing.

Skin Sensitization Test of Chamaecyparis obtusa essential oil in Guinea Pigs

Du Hyeon Hwang(황두현),Eun-Kee Park(박은기),Chang-Yeul Yoo(유창열),Suk Kim(김석),Euikyung Kim(김의경),Hu-Jang Lee(이후장) 한국예방수의학회 2019 예방수의학회지 Vol.43 No.3

Despite the various effects on the health of Chamaecyparis obtusa essential oil (COEO), an adverse effect on the skin has recently been reported. Therefore, in this study, the skin sensitization test of COEO was conducted to confirm the skin safety of the essential oil by the guinea pig maximization test. Guinea pigs were sensitized with intradermal injection of 0.1ml COEO for 24 h. After 1 week, 5% of COEO was treated on the site of injection and 2% of the essential oil was challenged 2 weeks later. The average skin reaction evaluated by erythema and edema on the challenge sites and sensitization rate in the COEO-treatment group at 24 h were 0.0 and 0%, respectively, which are substantially low compared with in the 2,4-dinitrochlorobenzene-treatment group (positive control group) (average skin reaction: 3.0, sensitization rate: 100%) and identical with in the olive oil-treatment group (negative control group), representing a weak sensitizing potential. The average skin reaction and sensitization rate observed at 48 h were 0.0 and 0% in the COEO-treatment group, respectively, and 2.0 and 100% in the positive control group, respectively. It was concluded that 5% of COEO classified to Grade I, induced no sensitization when tested in guinea pigs.

A Revised Dynamic ROI Coding Method Based On The Automatic ROI Extraction For Low Depth-of-Field JPEG2000 Images

박재흥(Jae-Heung Park),김현주(Hyun-Joo Kim),심종채(Jong-Chae Shim),유창열(Chang-Yeul Yoo),서영건(Yeong-Geon Seo),강기준(Ki-Jun Kang) 한국컴퓨터정보학회 2009 韓國컴퓨터情報學會論文誌 Vol.14 No.10

본 논문에서는 낮은 피사계 심도 JPEG2000 이미지의 복원 과정에서 관심영역을 자동으로 추출하여 우선적 처리하는 개선된 동적 관심영역 코딩 방법을 제안한다. 제안한 방법은 기존 방법과는 달리 사용자의 관심영역 지정 과정을 거치지 않고, DWT(Discrete Wavelet Transform)에서 특정 레벨의 고주파 서버 밴드를 사용하여 에지 마스크 정보를 생성한 후에 자동 에지 코드 블록 판별 알고리즘을 사용하여 관심영역을 빠르게 처리한다. 이 알고리즘은 에지 임계값과 4 방향(동, 서, 남, 북)으로 코드 블록 단위의 에지 마스크 정보를 이용하여 에지 코드 블록을 판별한다. 본 알고리즘을 기존의 Implicit 방법에 적용하여 실험한 결과, 제안한 방법이 기존의 방법들에 비해 속도와 품질 면에 있어서 우수함을 확인하였다. In this study, we propose a revised dynamic ROI (Region-of-Interest) coding method in which the focused ROI is automatically extracted without help from users during the recovery process of low DOF (Depth-of-Field) JPEG2000 image. The proposed method creates edge mask information using high frequency sub-band data on a specific level in DWT (Discrete Wavelet Transform), and then identifies the edge code block for a high-speed ROI extraction. The algorithm scans the edge mask data in four directions by the unit of code block and identifies the edge code block simply and fastly using a edge threshold. As the results of experimentation applying for Implicit method, the proposed method showed the superiority in the side of speed and quality comparing to the existing methods.

Ortho-phenylphenol을 주성분으로 하는 훈증소독제의 돼지열병바이러스와 돼지생식기호흡기증후군바이러스에 대한 살바이러스 효과

차춘남 ( Chun Nam Cha ),박은기 ( Eun Kee Park ),정지윤 ( Ji Youn Jung ),유창열 ( Chang Yeul Yoo ),김석 ( Suk Kim ),이후장 ( Hu Jang Lee ) 한국가축위생학회 2016 韓國家畜衛生學會誌 Vol.39 No.2

In this study, the virucidal efficacy of a fumigant containing 20% ortho-phenylphenol against classical swine fever virus (CSFV) and porcine reproductive and respiratory syndrome virus (PRRSV) was examined. After each carrier deposited with CSFV and PRRSV suspensions was exposed to the fumigant in a 25-m3 test room for 15 h, all carriers were neutralized and diluted, and each diluted suspension was inoculated into each proper cell line. After incubation, CSFV and PRRSV viability in each cell line was examined and 50% tissue culture infectious dose (TCID50)/mL was calculated. In the results, the concentration of viable virus in all of pathogen control-carriers was more than 2×105 TCID50/mL, and there were no cytotoxicity in all of toxicity control-carriers. In addition, the fumigant inactivated ≥4.8 log10(TCID50/mL) of both CSFV and PRRSV. These findings will be useful for preventing the spread of CSFV and PRRSV infection.