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수종의 알레르기 관련 약물이 흰쥐의 복강내 비만세포에서 Hyaluronidase 및 히스타민 유리에 미치는 영향
유신애,김구자,하종식,Yoo, Shin-Ae,Kim, Ku-Ja,Hah, Jong-Sik 대한생리학회 1988 대한생리학회지 Vol.22 No.2
Type I allergic reaction and it's related clinical manifestations are known to occur by the effects of various chemical mediators. These chemical mediators are released from circulating basophils and tissue mast cells, which become 'sensitized' through the binding of antigens and antibodies of the IgE type to their cell surface receptors. Efforts to elucidate the mechanism of the release of these mediators, especially that of histamine, have been persued for years. The mechanism is not yet clarified at the present time. Recent reports of hyaluronidase, an enzyme known to be involved in the tissue inflammatory process, as possible participant in type I allergic reaction, initiated this study. Relationships between the hyaluronidase activity and histamine release from the sensitized rat peritoneal mast cells were investigated. Also anti-allergic agents, tranilast and disodium cromoglycate, along with known histamine releasers, morphine and compound 48/80, were used to observe the inhibitory and stimulatory effects of these substances on the hyaluronidase activity as well as histamine release from the rat mast cells. The results obtained are summarized as follows: 1) Hyaluronidase activity and histamine release from sensitiaed rat peritoneal mast cells started to increase on the 4th day of postsensitization. Hyaluronidase activity reached it's peak value on the 7th day of postsensitization and that of histamine release on the 14th day of postsensitization. 2) Hyaluronidase activity and histamine release from sensitized rat peritoneal mast cells, pre-treated with tranilast revealed significant decrease in comparison with those of non-treated cells. 3) Hyaluronidase activity and histamine release from sensitized rat peritoneal mast cells, pre-treated with tranilast, followed by morphine injection, revealed significant increase in comparison with those of tranilast treated cells. 4) In vitro study of hyaluronidase activity and histamine release from un-sensitized rat peritoneal mast cells, using morphine and compound 48/80 as activators, revealed significant increase compared to those of non-activator used cells. 5) In vitro study of hyaluronidase activity and histamine release from un-sensitized rat peritoneal mast cells, pre-treated with tranilast and disodium cromoglycate, using confound 48/80 and morphine as activators revealed significant decrease in comparison with those of tranilast and disodium cromoglycate treated cells. From above results, participation of enzyme hyaluronidase in the process of histamine release from sensitized rat pertioneal mast cells, could be suggested. It was also quite evident that the clinically used anti-allergic agents, tranilast and disodium cromoglycate, have significant inhibitory function on the hyaluronidase activity and histamine release from sensitized rat peritoneal mast cells, while morphine significantly increased the hyaluronidase activity and histamine release from sensitized rat peritoneal mast cells.
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정지곤,유신애 충남대학교 기초과학연구소 1995 연구논문집 Vol.15 No.-
광물과 암석으로 구성된 골재와 이를 둘러싼 시멘트 페이스트 사이의 알카리-골재반응이 콘크리트 구조물에 팽창을 일으킨다는 사실은 잘 알려져 있다. 그러한 팽창은 구조물에 심각한 손상을 야기시키기 때문에 많은 나라에서는 구조물에 사용된 동일한 골재와 시멘트로 공시체를 제작하고 실험실에서 이의 팽창 촉진실험을 통하여 팽창률의 상한선을 규정하고 있는데 이는 0.1%이다. 위 실험의 규정은 미국의 경우 ASTM C227와 490에, 우리나라의 경우 한국공업표준협회에서 발간한 KS 핸드북 F2503, F2536 및 L5107에 명시되어 있다. 양자의 내용은 거의 동일하다. 이 규정에 따라 실험용 공시체를 제작하고 팽창정도를 측정하는데 위에 소개한 규정은 현장에서 현실적으로는 적합하겠으나 연구의 목적으로 정밀한 실험을 위해서는 아래와 같은 문제점이 발견된다. 첫째, 골재, 시멘트 및 물의 배합비를 규정함에 있어서 골재를 무게로 표현한 점. 둘째, 팽창률계산에 있어서 분모의 값을 254mm로 고정시킨 점. 셋째. 골재의 종류에 관계없이 공시체의 초기길이 측정길이를 24±2시간 후로 통일시킨 점. 넷째, 골재의 비중측정 방법은 목적에 따라 선택되어야 하나 그 중에서 진비중에 의한 측정이 가장 정밀도가 높다. It has been well known that the alkali-aggregate reaction between the aggregates and cement paste is one of the reasons of a concrete structure expansion. Because of a serious demage on the concrete structure from the expansion, in many countries, the safety of the materials is checked in laboratory by mortar-bar test and the upper limit of expansion in length is 0.1%. The prescriptions are presented in the ASTM C227 and 490 of U.S. which has been international currency and in the KS Handbook F2503, F2546 and L5107 of Korea published by Korean Standards Association. Both of the prescriptions are almost in their contents. Actually, in the process of preparing and measuring the mortar-bar according to the prescription mentioned above, it seems that there are no problems for its own purpose but a few points are found to be improved upon the methods to increase the accuracy for laboratory work as follows. 1. The prescription of blending ratio(aggregate, cement and water) should be noted by volume not by weight. 2. It is unreasonable to measure the initial length of mortar bars after 24±2 hours at once regardless the kind of aggregates. 3. It may bring about errors in calculating the expansion ration under the condition of the denominator value kind of aggregates. 4. The measuring methods of specific gravity are selected according to the purposes but the pure specific gravity displays the highest accuracy among them.
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