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유승호,Ryu, Seung Ho 대한생물정신의학회 2002 생물정신의학 Vol.9 No.1
Even though alcoholism is a multi-factorial psychiatric disorder, it is reasonable to suppose that genetic factors play a substantial role in the manifestation of this disorder. Because alcohol is the reinforcing substance which manifests its effects through activation of the mesolimbic dopaminergic reward pathway of the brain, the gene encoding dopamine receptor subtypes can be a major natural candidate gene. Since 1990, many association studies have identified strong evidence implicating the dopamine D2 receptor(DRD2) gene in alcoholism, specifically TaqI A minor(A1) allele. Association studies have also been conducted on other dopamine receptor(DRD3 & DRD4) polymorphisms but the results have yet to be confirmed. Through a number of other approaches, each dopamine receptor gene has been investigated in association with different phenotypes in alcoholism, but further researches will be needed. In conclusion, studies in the past decade have shown that the TaqI A1 allele of the DRD2 gene is associated with alcoholism in various subject groups. Other dopamine receptor genes have since been added to the list but yet to be identified. Thus, the knowledge of these genes and their functional significance will enhance the understanding of the underlying biological mechanisms of alcoholism. Furthermore, it could lead to more helpful prevention and treatment approaches to alcoholism.
한국인 알코올 중독환자에서 도파민 D4 수용체의 대립 유전자 연관성에 대한 연구
유승호,이민수,Ryu, Seung Ho,Lee, Min Soo 대한생물정신의학회 2001 생물정신의학 Vol.8 No.2
The dopamine D4 receptor gene has a hypervariable segment in the coding region characterized by a varying number of 48bp repeats in exon III of the gene. Varying the numbers of repeated segments may change the length, structure, and function of the receptor, which makes this gene a possible candidate for variations in dopamine-related behaviors, such as alcoholism and drug abuse. We evaluated the dopamine D4 receptor genotype in male alcoholics and normal controls. All alcoholics and controls were unrelated and from the Korean population. Genotype and allele frequencies in 67 alcoholics were compared to 67 controls who were free of alcohol abuse, substance abuse, and major mental illness. No association was found between the dopamine D4 receptor allele and alcoholism. This result indicate that there is no association of the dopamine D4 receptor with alcoholism in Korean. Further systemized investigation to determine the role of dopamine D4 receptor gene in alcoholism with a larger sample size will be required.
유승호(Seung Ho Ryu) 대한노인정신의학회 2007 노인정신의학 Vol.11 No.1
Dementia is one of the most common psychiatric problem in the elderly. According to the increase of the older people with dementia, management of dementia need to be systemized at the community level. The local center for dementia will be established for the community-based systematic and comprehensive management of dementia. It will be extended to all provinces of Seoul Metropolitan City. Activities of the local center for dementia includes 1) education, prevention, and public relations for dementia, 2) early detection and intervention for dementia, 3) establishment of effective, continuous, and personalized management system for the patient with dementia, 4) the development and promotion of community-based resources, 5) the construction of information and data related to dementia care system. This activity will increase the quality of life in the elderly with dementia and their caregivers. Finally, this management system for dementia may contribute to enhancement of the quality and the cost-effectiveness of community health promotion system for the older people.
유승호(Seung Ho Ryu),정인과(In Kwa Jung) 대한노인정신의학회 2006 노인정신의학 Vol.10 No.2
Anxiety disorders are common psychiatric illnesses in the elderly. However, anxiety disorders in older people have not drawn much attention from researchers and clinicians alike, compared with late-life depression or dementia. The author searched for articles published from 1986 to 2006 using the key words including "anxiety", "elderly", "aged", and "pharmacological" therapy in the MEDLINE, PsychINFO, and KMbase in order to clarify effective pharmacological therapy in the elderly with anxiety disorders. Well designed studies for pharmacologic intervention in late-life anxiety disorders were rarely found. Nonetheless, studies on young adults demonstrated a number of pharmacological treatment options that can be applied to these patients. Pharmacologic treatmentsfor the elderly include therapies using antideprssants, especially SSRI or SNRI, buspirone, or benzodiazepines. The latter requires special caution in the administration in the elderly because it can lead to adverse events. Therefore, well designed clinical trials are further needed to obtain optimal pharmacological intervention for the elderly with anxiety disorders.