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RISS 인기검색어
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- 저자 : 유승호(Ryu Seung-Ho) (검색결과 74 건)
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유승호,Ryu, Seung Ho 대한생물정신의학회 2002 생물정신의학 Vol.9 No.1
Even though alcoholism is a multi-factorial psychiatric disorder, it is reasonable to suppose that genetic factors play a substantial role in the manifestation of this disorder. Because alcohol is the reinforcing substance which manifests its effects through activation of the mesolimbic dopaminergic reward pathway of the brain, the gene encoding dopamine receptor subtypes can be a major natural candidate gene. Since 1990, many association studies have identified strong evidence implicating the dopamine D2 receptor(DRD2) gene in alcoholism, specifically TaqI A minor(A1) allele. Association studies have also been conducted on other dopamine receptor(DRD3 & DRD4) polymorphisms but the results have yet to be confirmed. Through a number of other approaches, each dopamine receptor gene has been investigated in association with different phenotypes in alcoholism, but further researches will be needed. In conclusion, studies in the past decade have shown that the TaqI A1 allele of the DRD2 gene is associated with alcoholism in various subject groups. Other dopamine receptor genes have since been added to the list but yet to be identified. Thus, the knowledge of these genes and their functional significance will enhance the understanding of the underlying biological mechanisms of alcoholism. Furthermore, it could lead to more helpful prevention and treatment approaches to alcoholism.
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한국인 알코올 중독환자에서 도파민 D4 수용체의 대립 유전자 연관성에 대한 연구
유승호,이민수,Ryu, Seung Ho,Lee, Min Soo 대한생물정신의학회 2001 생물정신의학 Vol.8 No.2
The dopamine D4 receptor gene has a hypervariable segment in the coding region characterized by a varying number of 48bp repeats in exon III of the gene. Varying the numbers of repeated segments may change the length, structure, and function of the receptor, which makes this gene a possible candidate for variations in dopamine-related behaviors, such as alcoholism and drug abuse. We evaluated the dopamine D4 receptor genotype in male alcoholics and normal controls. All alcoholics and controls were unrelated and from the Korean population. Genotype and allele frequencies in 67 alcoholics were compared to 67 controls who were free of alcohol abuse, substance abuse, and major mental illness. No association was found between the dopamine D4 receptor allele and alcoholism. This result indicate that there is no association of the dopamine D4 receptor with alcoholism in Korean. Further systemized investigation to determine the role of dopamine D4 receptor gene in alcoholism with a larger sample size will be required.
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유승호(Seung Ho Ryu),정인과(In Kwa Jung) 대한노인정신의학회 2006 노인정신의학 Vol.10 No.2
Anxiety disorders are common psychiatric illnesses in the elderly. However, anxiety disorders in older people have not drawn much attention from researchers and clinicians alike, compared with late-life depression or dementia. The author searched for articles published from 1986 to 2006 using the key words including "anxiety", "elderly", "aged", and "pharmacological" therapy in the MEDLINE, PsychINFO, and KMbase in order to clarify effective pharmacological therapy in the elderly with anxiety disorders. Well designed studies for pharmacologic intervention in late-life anxiety disorders were rarely found. Nonetheless, studies on young adults demonstrated a number of pharmacological treatment options that can be applied to these patients. Pharmacologic treatmentsfor the elderly include therapies using antideprssants, especially SSRI or SNRI, buspirone, or benzodiazepines. The latter requires special caution in the administration in the elderly because it can lead to adverse events. Therefore, well designed clinical trials are further needed to obtain optimal pharmacological intervention for the elderly with anxiety disorders.
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유승호(Seung Ho Ryu),이동우(Dong Woo Lee),이강준(Kang Joon Lee),한은주(Eun Joo Han),정한용(Han Yong Jung) 대한노인정신의학회 2006 노인정신의학 Vol.10 No.1
There has been great progress in diagnosis of dementia. Diagnosis of dementia involves the early detection of a significant cognitive deficit from normal aging and differential diagnostic approach of the cause of the cognitive impairment. Although there is controversy whether screening tools are useful for early detection of dementia, many brief screening tests have been developed and widely used. The Mini-Mental State Examination (MMSE) is the brief instrument most commonly used to assess cognitive changes in dementia. The MMSE has limitations, but it has been translated into many languages with modest adjustments. It also has been translated and standardized into three Korean versions (MMSE-K, K-MMSE, MMSE-KC) and there are several studies comparing the diagnostic validities between Korean MMSE versions. All three versions have good validities for screening dementia. Other brief screening instruments that have been translated and standardized in Korean may have clinical utility in early diagnosis of dementia. In conclusion, use of screening instruments such as the MMSE, especially in high risk elderly group can be recommended to increase early detection of dementia.
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알쯔하이머형 치매에서 정신과적 증상과 관련된 SPECT 소견
유승호(Seung Ho Ryu),박청산(Chung San Park) 대한노인정신의학회 2000 노인정신의학 Vol.4 No.1
알쯔하이머형 치매환자의 상당수에서 질병의 경과중에 동반된 우울증상 및 정신병적 증상등의 정신과적 증상들을 경험하며, 이러한 정신병리 현상은 치매 자체로 인한 병태생리의 양상으로 발생할 것으로 생각된다. SPECT와 같은 기능적인 대뇌 영상기법은 이러한 특별한 정신생물학적인 이해를 촉진시킬 수 있다. 따라서 본 연구는 알쯔하이머형 치매에서의 특정 국소 대뇌혈류의 기능부전과 정신과적 증상과의 관련성에 대한 통합된 이해를 증진시키기 위해 시행되었다. 29명의 알쯔하이머형 치매 환자들을 대상으로 SPECT를 시행하였다. 대상 환자군에서 망상, 우울증상, 환각 및 착각 등 4가지 정신과적 증상을 조사하였고 각각의 증상에 따라 증상이 있는 군과 없는 군으로 나누어 시행한 SPECT 소견을 비교하였다. 결과적으로 우울증상이 있는 군과 우울증상이 없는 군의 경우 그리고 망상이 있는 군과 망상이 없는 군의 경우는 SPECT 검사소견 상 어떤 부위에서도 통계적으로 유의한 혈류의 차이를 보이지 않았다. 환각이 있는 군의 경우는 환각이 없는 군에 비해서 양측 후두엽과 양측 측, 두정엽에서 통계적으로 유의하게 저하된 혈류소견을 보였다. 착각을 보이는 군은 착각을 보이지 않는 군과 비교하였을 때 통계적으로 유의한 차이를 보이지 않았다. 본 연구결과는 일부 정신과적 증상과 국소적인 대뇌혈류 변화와의 관련성을 보여주고 있다. 결론적으로, 이러한 연구를 통해서 향후 치매에서의 다양한 형태의 정신과적인 증상에 대한 전반적 혹은 국소적 대뇌기능부전을 양적으로 측정하고, 예상되는 기저의 신경해부학적인 이해 및 증거를 제시하는데 적용될 수 있을 것으로 생각된다. Objectives : The course of Alzheimer's disease is often complicated by psychiatric symptoms including depression, delusion and hallucination. And these psychiatric symptoms may be due to neuropathological changes of the disease itself. This study examined whether psychiatric symptoms in Alzheimer's disease are associated with cerebral perfusion using single photon emission computed tomography (SPECT). Methods : Supratentorial transaxial perfusion measurements were obtained in frontal, anterior temporal, posterior temporoparietal and occipital cortical areas in both hemispheres, in a baseline population of 29 mild to moderately impaired AD patients. We interviewed all the patients and their primary caregivers to assess their current and past psychiatric functioning. To compare the SPECT findings, all the patients were divided into two groups by presence of depression, delusion, hallucination and illusion, of which symptoms were explored separately. Results : The patients with hallucination had hypoperfusion of both the posterior temporoparietal and the occipital regions of interest, compared with scans of the patients without hallucination. And in other symptom profiles, there was no difference in SPECT findings between the patients with symptoms and without symptoms. Conclusion : Psychotic patients with Alzheimer's disease had a pattern of cerebral perfusion deficits, which is different from that of nonpsychotic patients. This finding suggests that specific patterns of cerebral dysfunction probably be related to the specific psychiatric symptoms in Alzheimer's disease.
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유승호(Seung Ho Ryu) 대한노인정신의학회 2007 노인정신의학 Vol.11 No.1
Dementia is one of the most common psychiatric problem in the elderly. According to the increase of the older people with dementia, management of dementia need to be systemized at the community level. The local center for dementia will be established for the community-based systematic and comprehensive management of dementia. It will be extended to all provinces of Seoul Metropolitan City. Activities of the local center for dementia includes 1) education, prevention, and public relations for dementia, 2) early detection and intervention for dementia, 3) establishment of effective, continuous, and personalized management system for the patient with dementia, 4) the development and promotion of community-based resources, 5) the construction of information and data related to dementia care system. This activity will increase the quality of life in the elderly with dementia and their caregivers. Finally, this management system for dementia may contribute to enhancement of the quality and the cost-effectiveness of community health promotion system for the older people.
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