예방소방행정의 발전방향에 관한 연구[I] -서울특별시 건축물의 소방시설을 중심으로-

유소현 한국화재소방학회 1992 한국화재소방학회논문지 Vol.6 No.2

친환경 식생활과 간헐적 채식의 연계성 고찰

유소현 한국환경교육학회 2022 한국환경교육학회 학술대회 자료집 Vol.2022 No.12

항산화 식물의 페놀성화합물에 의한 PC12 세포보호 효과연구

유소현,김건희 한국식생활문화학회 2018 韓國食生活文化學會誌 Vol.33 No.1

This study was designed to evaluate the antioxidant activities and protective effects on PC12 cells of the extract of Epimedium koreanum and its main constituents icariin and icariside I. After screening the seven identified flavonoid glycosides from E. koreanum through DPPH (2,2-diphenyl-1-picryl-hydrazyl-hydrate) assay, E. koreanum, Icariin and Icariside I exhibited significant effect on radical scavenging activity. E. koreanum, icariin and icariside I were examined using DPPH, ABTS (2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)) and FRAP (ferric reducing ability power) assay. In all antioxidant assays, E. koreanum, icariin and icariside I showed high radical scavenging activities in a dose-dependent manner. Protective effects against H2O2-induced PC12 cells were assessed with MTT assay. The results indicated that cell viability and protection on PC12 cells of icariside I and icariin increased dose dependently. These study results suggest that E. koreanum, icariin and icariside showed high antioxidant capacities and cell protective effects. Icariside I, one of the metabolites of icariin, may be a new and effective flavonoid compound as a functional component.

대구치 치근융합의 발생빈도와 분포및 성별과의 관련성 조사

유소현,허수례,이수정,장문택,김형섭,Ryu, So-Hyun,Heo, Soo-Rye,Lee, Su-Jeong,Chang, Moon-Taek,Kim, Hyung-seop 대한치주과학회 2002 Journal of Periodontal & Implant Science Vol.32 No.1

The objective of this study was to determine the incidence and distribution of root fusion as well as its sexlinkage in maxillary and mandibular molars. One hundred fifty patients who had eight maxillary and mandibular molars (third molars excluded) were consecutively selected for the study subjects. The subjects provided a total of 1200 molars, i.e., 600 maxillary and 600 mandibular molars. A decision about root fusion was made on the radiographic examination. If a molar had one root and/or roots fused at any part in the root surface, it was considered as having root fusion. The results showed that : (1) 14.1 % of the maxillary molars and 5.8 % of the mandibular molars had a fused root, (2) the prevalence of root fusion in the male was 33 % and 56.4 % in the female, (3) 60 % in the male and 48.8 % in the female had bilaterally paired root fusion, (4) the root fusion was most frequently observed in the maxillary second molar position, but none in the mandibular first position in this study. Within limitations of this study, it can be concluded that, in management of molars with a furcation problem, treatment options such as hemisection and root amputation should be chosen after careful evaluation of root fusion. Further studies are needed to investigate a possible relationship between root fusion and periodontal disease progression.

豫防消防行政의 發展方向에 관한 硏究[Ⅰ] : 서울特別市 建築物의 消防施設을 中心으로

柳昭賢 社團法人 韓國消防學會 1992 한국화재소방학회논문지 Vol.6 No.2

임상시험용 의약품 복약지도 항목에 대한 임상시험대상자 및 연구자의 요구도 조사

유소현,김유경,이정선,한옥연,나현오 한국병원약사회 2017 병원약사회지 Vol.34 No.1

Medication counseling in clinical trials is important for patient safety and implementation of the scientific method. During clinical trials, although basic information about the drug is provided through the participant instructions, there is a lack of research on the extent of the patient awareness of this information, demand for medication guidance by participants, and the appropriate medication guidance methods. A survey was conducted by us in September 2014, enrolling subjects self-administering drugs for a clinical trial, and a study on the principle investigator (PI) and clinical research coordinator (CRC) participating in the clinical trials. The survey related to preferences for medication counseling methods and demand for specific categories, as well as other additional items for clinical trial subjects, to evaluate their awareness of the drugs in the clinical trial. We analyzed the responses of 111 clinical trial subjects and 67 investigators (21 PI and 46 CRC). In terms of preferences for medication counseling methods,‘ written and oral guidance together’was high for both subjects and investigators. When inquired regarding categories for which medication counseling was required, subjects gave the most positive responses for‘ adverse effects’(96.3%) and‘ drug interactions’( 95.4%), while investigators responded highly for ‘methods of use’(100%) and ‘adverse effects’ (100%). The category‘ methods of use’especially showed a significant difference between investigators and subjects in terms of positive response rate, at 100% and 91.7%, respectively (p 0.0001). Categories in which the subjects’awareness of the drugs in the clinical trial was lacking included ‘difference with drugs on the market’(58.6%),‘ interactions with other drugs’(50.5%), and‘ whether the drug is available for sale’(45.1%). Meanwhile, the criteria high on the list of investigators included accurate clinical trials, including guidance about methods of use and dealing with missed doses. Based on the categories revealed by our survey, it will be possible to suggest constituent elements for medication counseling in the future, that accounts for the demands of both subjects and investigators regarding drugs in clinical trials.

연구논문 구연발표 : 대구치 치근융합의 분포와 성별과의 관련성 조사

유소현,장문택,강형섭 대한치주과학회 2001 대한치주과학회 학술대회자료집 Vol.2001 No.1

약사에 의한 항암처방 중재 분석 및 처방 오류 개선 효과

유소현,고영주,박애령,김순주,나현오 한국병원약사회 2012 病院藥師會誌 Vol.29 No.2

Chemotherapy prescription shows high frequency of prescription changes and errors, according to the condition of the patient and their response to such treatment. Therefore, occurrence of problems in the patient’s safety control might cause extended period of treatment and increasing possibilities of adverse reactions. This study is aimed to analyze the current status of the prescription intervention, to estimate the importance of prescription review by the pharmacist, and to assess the role of the pharmacist to prevent prescription errors. From January to August in 2010, in the oncology department of our hospital, 16,754 chemotherapy prescriptions were examined and 539 of them had prescribing errors, which were corrected by the pharmacists. In order to find the effectiveness of using computerized chemotherapy protocol, trans-arterial chemoembolization (TACE) protocols of gastroenterology, which were newly registered and pediatric chemotherapy protocols, which were modified from the existing protocols have been analyzed in difference of error incidence during the data collecting period. As a result of analyzing the prescribing errors, the errors about infusion solution contained 290 cases (53.8%) that were related to the final concentration of the diluted solution and 70 cases (13.0%) with missing infusion solution for dilution. Among the errors about dosage, 33 cases (6.1%) were intervened for exceeding the maximum dose, 30 cases (5.6%) for inputting wrong indicators, which determined chemotherapy dose, and 29 cases (5.4%) for mistake of entering dosage. The number of error cases in selecting chemotherapy protocol and entering drug code was 27(5.0%) and 26(4.8%), respectively. The prescribing errors before and after using TACE protocols showed a significant decrease (p=0.0002). In case of pediatric clinic, the prescribing errors, before and after modifying protocols were 3.1% and 2.7%, respectively. Although the prescribing errors after correcting system decreased compared to that of the former protocol use, statistical value has not been proven (p=0.409). The results showed that the prescribing error decreased after entering new protocols or correcting the protocols, thus, the study can convince medical staffs to use chemotherapy protocols for a decrease in the prescription errors. But, also prescription review and intervention, considering the individual specific medical information by pharmacist, will make chemotherapeutic agents to be administered safely to cancer patients.

방글라데시 식물 추출물의 항산화 및 항염 효과 연구

유소현,김건희,You, SoHyeon,Kim, Gun-Hee 한국식생활문화학회 2020 韓國食生活文化學會誌 Vol.35 No.6

In this study, 11 plant extracts from Bangladesh were used to evaluate the total phenolic and flavonoid content, in vitro antioxidant activities using 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2-azinobis-(3-ethylbenzthiazolin-6-sulfonic acid) (ABTS), and ferric reducing antioxidant power (FRAP) assay. Also, the inhibitory effect of nitric oxide (NO) production in RAW 264.7 macrophage cell line and the neuroprotective effect on H2O2-induced PC12 cells were tested. Our results revealed that Piper betle L. showed the highest total phenolic content (162.2 mg GAE/g extract) among the 11 plants from Bangladesh. Most plants showed strong radical scavenging effects and ferric reducing antioxidant power. Besides, Piper betle L. protected PC12 neuronal cells against H2O2 related oxidative stress in LPS-induced PC12 cells. Regarding the anti-inflammatory effect, Piper betle L. significantly inhibited NO accumulation in LPS-induced RAW 264.7 cells. Our results provide evidence that Piper betle L. could be useful for the development of functional health foods.

소규모 사업장에서의 보건관리자 역할

유소현(SoHyun Yoo) 대한인간공학회 2019 대한인간공학회 학술대회논문집 Vol.2019 No.10