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DRM의 기술.시장 동향- DRM 기반 유비쿼터스 콘텐츠 서비스 시대 도래
유세근,Yu, Se-Geun 한국데이터베이스진흥원 2004 디지털콘텐츠 Vol.12 No.-
유무선 경계가 사라지고 유비쿼터스 시대로 다가서면서 DRM(Digital Right Management)에 대한 관심이 고조되고 있으며, 디지털 음악을 비롯한 게임, 동영상 등의 여러 분야에서 그 필요성을 인정받고 있다. DRM에 대한 기술적 배경과 동향, 적용사례 등에 대해 살펴본다.
남석우(Suk Woo Nam),박승희(Seung Hee Park),유세근(Se Geun Yu),서동완(Dong Wan Seo),김형식(Hyung Sik Kim),이병무(Byung Mu Lee),심점순(Jeon Soon Shim),유영효(Young Hyo Yu),박명환(Myung Hwan Park),이향우(Hyang Woo Lee) 한국응용약물학회 1994 Biomolecules & Therapeutics(구 응용약물학회지) Vol.2 No.3
The acute toxicity of DWP305 (Ursodeoxycholic acid : Silymarin : Fursulthiamine : Riboflavin tetrabutyrate=1 : 1 : 0.1 : 0.05) was evaluated in both sexes of Sprague-Dawley rats, 6 weeks old by the oral route of administration. DWP305 was not considered to induce any toxic effect on the rats in mortalities, clinical findings, body weights and gross findings. It is suggested that LD_(50) value in rats would be above 5 g/㎏ in the oral administration. Subacute toxicity of DWP305 was examined in Sprague-Dawley rats. Four groups of rats were administered orally at doses of 0, 0.32, 0.8, and 2.0 g/㎏/day of DWP305 for one month. Any significant toxic clinical symptom was not observed in the treated rats during the experimental period. Macroscopic examination on the organs of tested animals showed no abnormal findings. On autopsy, no significant changes were found in organs examined. Maximum tolerated dose of DWP305 for the rat was estimated to be above 2 g/㎏ in this study.
Carbachol에 의한 닭 췌조직내 nitric oxide synthase 활성 및 methylated arginine 함량변화
유세근,남석우,박승희,남태균,서동완,한정환,홍성렬,이향우 성균관대학교 약학연구소 1994 成均藥硏論文集 Vol.6 No.1
The role of nitric oxide (NO) in the regulation of exocrine secretion was investigated in chicken pancreatic tissues. Nitric oxide synthase (NOS) in the pancreatic tissues were Ca^2+-dependent form. Treatment of tissue with L-arginine (10 mM) or carbachol (10^-5 M) showed the increase of pancreatic exocrine secretion, but that of D-arginine (10 mM) did not. ^3H-citrulline formation, cyclic GMP level and methyl arginine contents in the homogenates of pancreatic tissues treated with carbachol were not affected. Although the action mechanism of NO in the pancreatic tissues remains unknown, NO apparently participates significantly in the overall control of pancreatic secretory function.