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한국인 류마티스 관절염 환자에서 질병 중증도 표지자로서의 HLA-DR4 유용성
임미경 ( M. K. Lim ),이창근 ( C. K. Lee ),최승원 ( S. W. Choi ),주용선 ( Y. S. Ju ),주유숙 ( Y. S. Cho ),김성문 ( S. M. Kim ),신명진 ( M. J. Shin ),오흥범 ( H. B. Oh ),유빈 ( B. Yoo ),문희범 ( H. B. Moon ) 대한류마티스학회 2001 대한류마티스학회지 Vol.8 No.1
Objective: To investigate HLA-DR4, its subtype and shared epitope as a severity marker in Korean patients with rheumatoid arthritis. Methods: One hundred thirty-six RA patients were typed for HLA DR4 and HLA-DRB1 alleles by the polymerase chain reaction-sequence specific probe method. The patients were retrospectively evaluated for extra-articular features, presence of remission, and joint failure. Bony erosion score was assessed by Sharp`s method with modification. Results: Patients with HLA-DR4 had significantly higher prevalence of extra-articular features compared to those without the allele. However, there was no association of HLA-DR4, HLA-DRB1*0405 and shared epitope with rate of remission, joint failure, and bony erosion score. Eighty-two percent of patients were rheumatoid factor positive. With seropositive patients only, the results were the same as those above. Conclusion: HLA-DR4, HLA-DRB1*0405 and shared epitope are not a severity marker in Korean patients with RA in terms of radiological score, rate of joint failure, and rate of clinical remission. Data from this study do not support the clinical use of HLA-DR4 typing as a prognostic marker in Korean patients with RA.