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      • KCI등재

        편시력저하요인에 관한 한의학적 임상고찰

        우영민,남영,Woo, Young-Min,Nam, Young 대한한방안이비인후피부과학회 2002 한방안이비인후피부과학회지 Vol.15 No.2

        Visual acuity Decrease is one of the most common symptoms of adolescents. Acupuncture method has been used for improvement of visual acuity from ancient period. But it is not sufficent to recognize underlying causes and predisposing factors of visual acuity decrease. So we investigate the common causes and factors on myopia outpatients group. We researched 992 outpatients who were treated at Department of Acupuncture & Moxibustion, National Medical Center from June 2001 to May 2002. The outpatients were classified into several groups according to visual acuity and age. Common predisposing factors of visual acuity decrease were assessed through questionnaires based on the Classics of the traditional oriental medical bibliography. The results are as follows; age distribution is 52.9$\%$ for female, 47.1$\%$ for male. The predisposing factors were ranked as poor posture(66.9$\%$), unbalanced diet(57.2$\%$), heredity(53.8$\%$), irregular diet habit(51.3$\%$) and so on. These results playa role as preliminary data in recongnition of myopia in the view of oriental medicine.

      • KCI등재

        시상증후군(Thalamic Pain Syndrome) 환자의 한방 병합치료에 관한 임상적 고찰

        우영민,송경섭,이진헌,Woo, Young-Min,Song, Kyung-Sup,Lee, Jin-Hun 대한한방내과학회 2000 大韓韓方內科學會誌 Vol.21 No.5

        Objectives : To evaluate the pain control effect of combination treatment of Oriental Medicine on patients who suffered from thalamic pain syndrome caused by thalamic stroke. Methods : We reviewed the medical records and brain imaging data of all patients with thalamic stroke from September 1998 to August 2000 who visited to Department of Oriental Internal Medicine, National Medical Center. We evaluated clinical features of thalamic pain syndrome, including incidence, onset interval from stroke, nature, pain distribution, and assessed the pain control effect of combination treatment by Visual Analog Scale(VAS). Results : 64 cases were selected under the inclusion criteria, and 17 patients(26.5%) with thalamic pain syndrome were identified from 64 thalamic strokes. VAS proved combination treatment effective to control pain of thalamic pain syndrome. In 12 cases(70.5%), pain onset was within the first week poststroke. The patients with allodynia were 6(35.3%). In 12 cases(70.5%), the lesion was mainly located in the posterolateral areas of thalamus. Conclusion : We conclude that combination treatment of the Oriental Medicine modalities have pain control effectiveness on thalamic pain syndrome.(t=-5.47, p=0.0001)

      • KCI등재

        동측 및 대측 전침자극 전후의 뇌기능 변화에 관한 연구

        우영민,신병철,남영,Woo, Young-min,Shin, Byung-cheul,Nam, Young 대한침구의학회 2003 대한침구의학회지 Vol.20 No.1

        Objective : To ascertain whether the concept of the treatment side is associated with changes in the blind spot mapping that represents the brain function. Methods : Among the outpatients who visited to Department of Acupuncture & Moxibustion, National Medical Center from March 2002 to October 2002, we selected 40 clinical trial volunteers that showed right side physiological blind spot more enlarged than left, and underwent the examinations of Department of Opthalmology, National Medical Center for ruling out the pathological conditions. Physiological blind spot maps were used as an integer of brain activity before and after electroacupuncture application on the unilateral ST36 meridian point by dividing 40 subjects into two comparative groups for double-blind controlled study. Results: The significant changes in the blind spots were observed. Electroacupuncture application on the ipsilateral or contralateral ST36 of an enlargement cortical map were associated with the concept of determining the treatment side. In the case of electroacupuncture application on the ipsilateral side of an enlarged blind spot, there were decrease of $4.11{\pm}8.56cm$(17.3%) in blind spot perimetry length(p < 0.05). In the case of contralateral side, there were increase of $3.19{\pm}5.40cm$(13.7%) in blind spot perimetry length(p<0.05). The Differences were statistically significant(p<0.05). Conclusions: We found that eletroacupuncture application was associated with an increase or decrease in the brain function in the view of blind spot changes depending on the treatment side. These results suggest that the traditional acupuncture therapeutic strategy with determining the treatment side has clinical significance in the view of the brain function.

      • KCI등재

        針의 巨刺法에 對한 實證的 硏究 -眼球의 Blind spot 變化에 對하여-

        우영민,남영,Woo, Young-Min,Nam, Young 대한한방안이비인후피부과학회 2000 한방안이비인후피부과학회지 Vol.13 No.2

        objective to ascertain whether the concept of the therapeutic side is associated with changes in the blind sport mapping that represents the brain function. design Physiological blind spot maps were used as an integer of brain activity before and after acupuncture needling on the meridian point Hapkok(合谷) and Techung(太衝) in the unilateral side decided by double-blind controlled study(20 subjects). setting outpatient clinic participants: adult volunteers intervention twenty subjects were divided into two comparative groups and underwent specific acupuncture therapy on the unilateral side. Blinded examiners obtained reproducible pre and post-acupuncture cortical maps, which were subjected to statistical analysis. main outcome measures Brain activity was demonstrated by reproducible circumferential measurements of cortical hemispheric blind spot maps before and after acupuncture on the unilateral side. in case of acupuncture needling on the ipsilateral side of an enlarged side of bilnd spot, there were reduction of blind spot in 7 cases of 10 subjects, and enlargement in 3 cases. in case of acupuncture needling on the contralateral side of the enlarged side of blind spot, there were enlargement of blind spot in 6 cases of 10 subjects, and reduction in 4 cases. results the significant changes in the blind spots before and after acupuncture were observed Acupuncture needlings on the ipsilateral or contralateral side of an enlarged cortical map were associated with the concept of the therapeutic side traditionally accepted in the oriental medical society. Acupuncture needling on the ipsilateral side of an enlarged blind spot map is associated with the reduction of map, and increaed contralateral cortical activity. Acupuncture needling on the side opposite an enlarged blind spot map is associated with the enlargement of map, and decreased cortical activity. conclusion Reproducible maps of cortical responses can be used to measure the neurological consequences of acupuncture needling. Acupuncture can affect the somatic sensory informations that reach to the contralateral thalamus, and so affect thalamic integration. we found that acupuncture therapy may be associated with an increase or a decrease in brain function depending on the side of acupuncture needling. thus, the traditional concept of the contralateral therapeutic theory in acupuncture approach has the clinical significance in the view of brain function.

      • KCI등재

        슬관절 미세손상환자의 침치료에 관한 임상적 고찰

        우영민,이진헌,김진문,남영,Woo, Young-Min,Lee, Jin-Heon,Kim, Jean-Moon,Nam, Young 대한침구의학회 2000 대한침구의학회지 Vol.17 No.4

        Objectives : This study was performed to evaluate the clinical effect of acupuncture on microtraumatic injuries of the knee joint. Methods : Among the outpatients with knee joint pain who visited to Department of Acupuncture & Moxibustion, National Medical Center from February 2000 to September 2000, we selected 15 cases that showed normal finding in both X-ray and neurological examination, and that were categorized into microtraumatic injuries by the physical examination based on the Cyriax's orthopedic medicine. During acupuncture therapy, the patients were ordered to move involved side actively. The effect was assessed through questionnaires of CNRS(Cincinnati Knee Rating System). Results : We investigated 11 female and 4 male patients. The most common distribution of age was 30's(40%). The most commom duration of symtoms was from 3 to 5 months(40%). The most common microtraumatic injury was pes anserinus bursitis(33.3%), and followed by iliotibial band friction syndrome(20%), and patellar tendinitis(20%). In the CNRS, the mean number of before treatment was 60.6 and after was 66.5. 10 cases among the 15 patients were improved(66.6%). Conclusions : These results suggest that the acupuncture therapy combined with active movements of involved side was effective treatment modality on microtraumatic injuries of the knee joint.

      • KCI등재
      • KCI등재
      • KCI등재

        추출용액에 따른 유산균 발효 땅두릅의 항염증 효과

        우영민(Young Min Woo),김옥주(Ok Ju Kim),조은솔(Eun Sol Jo),조민영(Min Young Jo),안미영(Mee Young Ahn),이상현(Sang-Hyeon Lee),하종명(Jong-Myung Ha),김안드레(Andre Kim) 한국생명과학회 2018 생명과학회지 Vol.28 No.12

        본 연구는 추출 용매별 땅두릅 추출물과 Lactobacillus plantarum으로 발효한 후 용매별로 추출한 땅두릅 발효추출물을 이용하여 항염증 효과를 측정한 연구이다. 땅두릅은 중추신경 계통에 대한 흥분작용이 있고 혈압강하 작용이 알려져 있으며 관절염, 감기, 신경통, 류마티스, 피부가려움증 등에 쓰인다. LPS (lipopolysaccharide)로 염증을 유도한 마우스 유래 macrophage에서의 NO 생성 및 염증관련인자의 발현에 미치는 영향을 검토하여 항염증 소재로서의 이용 가능성을 확인하였다. 건조 땅두릅을 water, ethanol, hexane, ethyl acetate, butanol을 이용하여 추출한 추출물들과 L. plantarum으로 발효한 후 추출한 추출물들에서 RAW264.7 대식세포에 대한 독성 여부를 측정하였고, 세포에 대한 독성이 나타나지 않는 농도에서 추출물의 항염증 활성을 확인하였다. 본 실험에 사용된 추출물은 LPS로 유도된 NO 생성을 유의적으로 억제하였으며, 주요 염증 유발인자인 COX-2와 iNOS의 발현 또한 유의적으로 억제하는 효과를 나타냈다. 염증관련 cytokine인 IL-1β, IL-6 및 TNF-α의 생성량 또한 유의적으로 감소시켰다. 이상의 결과로부터 땅두릅을 L. plantarum으로 발효한 후 water, ethanol, butanol로 추출하였을 때 염증억제 효과가 있는 기능성 식품 소재로서의 개발 가능성이 있을 것으로 사료된다. We investigated the anti-inflammatory activities of various organic solvent extracts with and without Lactobacillus plantarum fermentation of Aralia continentalis Kitagawa which has hypotensive effects in addition to excitatory effects on the central nervous system. It has been used to treat arthritis, colds, neuralgia, rheumatism, and itchy skin. Our extracts were tested for their anti-inflammatory potential on NO production and the expression of inflammatory factors in lipopolysaccharide-stimulated RAW264.7 macrophages. Extracts with and without L. plantarum fermentation were prepared using water, ethanol, hexane, ethyl acetate, and butanol. The RAW264.7 cells were tested for toxicity and the anti-inflammatory activity of each extract was determined at a concentration with no toxicity to the cells. The extracts used in this study significantly inhibited both the production of NO and the mRNA expression of COX-2 and iNOS, the major inflammatory factors. The production of inflammation-related cytokines IL-1β, IL-6, and TNF-α was also significantly reduced. These results suggest that the extracts involving fermentation by L. plantarum can inhibit cytokines by controlling the expression of inflammatory cytokine genes. It is considered that the water, ethanol, and butanol extracts after fermentation with L. plantarum could be useful as functional natural materials with anti-inflammatory effects.

      • KCI등재
      • KCI등재

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