소아 전풍 환자에 대한 임상적 고찰

강효준,왕한영,성호석 ( Hyo Jun Kang,Han Young Wang,Ho Suk Sung ) 대한피부과학회 1997 大韓皮膚科學會誌 Vol.35 No.3

Background: Pityriasis versicolor(PV) is a superficial mycosis, theoretically unusual in children. Epidemiologic and clinical data for children with PV under 14 years were collected. Objective . The purpose of this study was to evaluate the clinical features of PV in the young. Method: We included all cases of PV in patients under 14 years of age observed in our department from 1981 to 1995. All cases were diagnosed on the basis of clinical criteria and were confirmed by microscopic examination. Results : From 1981 to 1995 we encountered 32 cases of PV in children, compared with 637 cases in adults; thus children represented 4.7% of all cases. The ratio of male to female was l. 7:1. Among the age groups, the incidence was the highest in the 10-14 years(43%). The monthly prevalence was the highest in August. Distribution of the lesions were the face(40.9%), neck (25%), chest(13.6%), back(11.3%), extremities(6.8%) and abdomen(2.2%). The incidence of hypopigmented lesions was 70.4% and that of hyperpigmented lesions was 29.6%. Conclusion : This study confirms that the face is a predilectionl site for PV in children and all facial lesions are hypopigmented. Other clinical features are variable and similar to those of adults. (Kor J .Dermatol 1997;35(3): 431-434)

표피박리성 과각화증

왕한영(Han Young Wang),최영자(Young Ja Choi),성호석(Ho Suk Sung) 대한피부과학회 1985 대한피부과학회지 Vol.23 No.4

Epidermolytic hyperkeratosis, previously called bullous congenital ichthyosiform erythroderma is a dominantly inherited disorcler and usually manifested by blisters at or shortly after birth. We report a case of epidermolytic hyperkeratosis in 9 year old girl vrho developed generalized erythema &: easily eroded vesicles at birth. Later the skin lesions progresed to characteristic thick, grayish-dark brown verruform cais, affecting predominantly flexural and intertriginous areas. Fiistologic findings show typical granular degeneration.

소아 아토피 피부염에서의 혈청 IgE 및 회상 항원을 이용한 피부 지연 면역 반응 검사 성적과 그 연관성

왕한영(Han Young Wang),최영자(Young Ja Choi),성호석(Ho Suk Sung) 대한피부과학회 1986 大韓皮膚科學會誌 Vol.24 No.2

We measured serum 1gE by using IgE 'Eiken' radioirnrnunoassay Kit and delayed cutaneous hypersensitivity responsiveness by the Multitest CMI Kit (Institut Merieux) that simultaneously administrates 7 standardized recall antigens(tetanus, diphtheria, streptococcus, tuberculin, candida, trichophyton, proteus) and 70% W/V glycerin diluent control by multiple prick puncture. We studied 40 cases comprising 20 patients with atopic dermatitis (AD) and 20 healthy children as control. The results were obtained as follows; 1) The mean serum level of IgE in AD(63$ 3-t-395 2 1U/ml) was higher than in control(155.6-67.1IU/ml) (p<0.0l), but the intensity of reaction (IR) & rate of reaction (RR) in AD (l. 34 + 1.06, 0.38+0.23) was not significantly decreased than in control (1.70+0.87,0.44+0.16). 2) 1n both AD & control group, tuberculin showed highest IR R RR. 3) Anergic state was found in only one patient with disseminated cutaneous lesions Sc 4) serum IgE, but rate of hypoergy was significantly increased in AD(65%) than in control (30%) (p<0.05). 4) Serum IgE was not statistically correlated with IR and RR, but IR was statistically correlated with RR (p<0.001, r=0.9504). 5) IgE level in severe AD (generalized skin lesion) was significantly increased than in both mild AD 8c control group (p<0. 001). but IR & RR were not statistically correlated with disease severity.

아토피피부염 환자에서 집먼지 진드기 항원에 대한 첩포시험과 특이 IgE치에 관한 연구

박준환 ( Joon Hwan Park ),왕한영 ( Han Young Wang ),성호석 ( Ho Suk Sung ) 대한피부과학회 1996 대한피부과학회지 Vol.34 No.5

Background: Recently several papers have been published dealing with positive patch reactions to house dust mite antigens in atopic dermatitis patients. The possibility that house dust mite antigens, brought in direct contact with the skin such as through the air, may contribute in the pathogenesis of the dermatitis, is an interesting aspect of the relationship between atopic dermatitis and allergic reactions. Objective : The purpose of this study is to evaluate type-IV and type-I hypersensitivity to house dust mite antigens in atopic dermatitis patients. Methods : We performed the patch test and chemiluminescent assay(CLA) for house dust mite antigens in 42 patients with atopic dermatitis and 10 normal controls. Results : 1. Positive reactions of the patch test in patients with atopic dermatitis were 11(26.2% ) for the Df antigen and 10(23.8%) for the Dp antigen. 2. Positive reactions of CLA in 42 patients with atopic dermatitis were 12(28.5%) for both Df and Dp antigen, but only one(10%) for both Df and Dp antigen in 10 normal controls. 3. A highly significant correlation to house dust mite antigens existed between the patch test and CLA, but some patients showed a positive reaction in the patch test despite the level of IgE which was in class 1 or 0. 4. There was no significant statistical correlation between the severity of atopic dermatitis and the positive reaction rate of both the patch test and CLA Conclusion : These results suggested that in atopic dermatitis patients with positive patch test reactions to house dust mite antigens, delayed type hypersensitivity reactions to these antigens might play an important role in the development of atopic dermatitis skin lesion . (Kor J Dermatol 1996;34(5): 762-768)

농가진의 원인균주 , 항생제 감수성 검사 및 치료에 대한 연구

박성욱(Sung Wook Park),왕한영(Han Young Wang),성호석(Ho Suk Sung) 대한피부과학회 1993 대한피부과학회지 Vol.31 No.3

Background : It is traditiqnally considered that the non-bullous fonn of impetigo is primarily of streptococcal origin and the bullous form is of staphylococcal origin. However, recent reports have shown that Staphylococcus aureus (SA) has become the predominant cauative pathogen of non-bullous impetigo as well as of bullous impetigo. Objective. Our purpose was to evaluate the predominant causativi. pathogen, and to establish a therapeutic guideline for impetigo. Method : We described the characteristics of lesions and gerformed bacterial culture and susceptibility tests in patients with impetigo. Patients were treatecl by one of three frequently used antibiotics(erythromycin, cefuroxime, fusidic acid). Results : Of 77 patients, there were 47 cases of crusted type(61.9%), 18 cases of mixed type with crusted and bullous lesiona(23.3%), 7 cases of mixed type with crusted and pustular lesions(9.1%) and 5 cases of bullous type(6.6%). SA was grown from 90.1% af the cases, in 83.1% of cases it was the only organism to be foind and no gowth of streptococcus was faund even in mixed infections. An antimicrobial susceptibility test of 63 strains of SA demonstrated high susceptibility to vancomycin(98.4%), cefuroxime(97.1%), oxacillin(96.4%), cephalothin(95.2%), fusidic acid(91.7%) etc, and high resistance to penicillin(93.7%), gentamicin(90.5%), tobramycin(88.9%) and erythromicin(80.9%). Of 19 patients treated with erythrornycin, 12(63.1% ) showed treatment failure at a weeks, while no treatment failure occured in groups treated with cefuroxime and usidic acid. There were statistically significant differences iri therapeutic effect between cefuroxirne and erythromycin(P=0.005 by two tailedy test), and betweer fusidic acid and erythromycin(P=0.0040. But there was no significant difference between cefuroxime and fusidic acid. Collclusion : The predominant pathogen of non-bullous impetigo a well as bullous impetigo was SA which were highly resistant to erythromycin and highly sensitive to efuroxime and fusidic acid. In the clinical response, cefuroxinie and fusidic acid treatment were most effective and erythromycin was inadequate for treatment of impetigo. (Kor J Dermatol 1993; 31(3); 312-319)

Acquired Tufted Angioma

왕정길 ( Jeong Kil Wang ),이학중 ( Hak Joong Lee ),왕한영 ( Han Young Wang ),윤혜경 ( Hye Kyoung Yoon ),박필성 ( Pill Sung Park ) 대한피부과학회 1998 대한피부과학회지 Vol.36 No.1

Acquired tufted angioma is a benign, slowly progressive angioma with a typical histological pattern that was first described by Wilson-Jones in 1976. We report a case of acquired tufted angioma in a 19 year old female who had erythematous papules and plaques on the right thigh. Histopathological findings showed multiple capillary lobules in a cannonball arrangement scattered throughout dermis, which was diagnostic of acquired tufted angioma. (Korean J Dermatol 1998;36(1): 164-167)

국군논산훈련소 훈련병의 성행태와 성인 질환 감염

박성욱 ( Sung Wook Park ),왕정길 ( Jeong Kil Wang ),왕한영 ( Han Young Wang ),박만수 ( Man Soo Park ) 대한피부과학회 1998 대한피부과학회지 Vol.36 No.5

Background : Almost all STD(sexually tranamitted diseases) have been increasing worldwide since the 1960s. In Korea, the occurrence of STD from recent trends of sexual openness and development in the pleasure-seeking industry is becoming a social issue. However, epidemiological studies and reports concerning the incidence of STD are lacking in Korea, especially in the sexually aetive young age group. Objective : We evaluated the incidence of YTD and sexual behavior of recruits in a Korean arrny training center to contribute to the management of STD in Korea. Metheds : We studied 1304 recruits in a Korean army training center by questionnaire, physical examination and laboratory data. The subjects were divided into 3 groups: group 1(1072 persons), those who visited the hospital for evaluation of STD; group 2(641 persons), a control group for coitus rate; and group 3(1304 persons; group 1 plus 232 persons out of group 2), those who had coital experiences. Results . 1. The incidence of STD in group 1 was 65.7%(704/1072) and that of the total number of recruits was 0.43%(704/164,134). 2. Among the 704 cases of STD, the most frequently observed STD was non-gonococcal urethritis, 292 cases(41.5%) and the second was gonorrhea, 236 cases(33.5%). The others were, 68 cases(9.7%) of pediculosis pubis, 41 cases(5.8%) of condyloma acuminatum, 29 cases(4.1%) of syphilis, 20 cases(2.8%) of combined STD, 14 cases(2%) of herpes progenitalis, 2 cases(0.28%) of molluscum cohtagiosum and 2 cases(0.28%) of chancroid. 3. The coitus rate in group 2 was 36.2%(232/641). 4. The incidence of previous STD in group 3 was 20.9%(273/1304). 5. The mn;t common form of STD which the patients experienced previously was urethritis(82.8%) and the others were pediculosis pubis(7.3%), syphilis(3.3%), condylcena acuminahun and herpes progenitalis. 6. The group with more sexual partners tended to have a lower educational level. 7. The experience rate of drug abuse was higher in the group with more sexual partners. 8. The experience rate of oral and anal sex was higher in the group with experiences of clrug abuse than in the ather one. Conclusion . In this study, urethritis was the most common form of STD(75% of all STD) and non-gonococcal urethritis showed a greater incidence than gonorrhea. The incidence of STD is thought to be closely related to the factors associated with social or behavioral science, such as the number of sexual partners, grade of education, drug abuse, experience of oral and anal sex. To accomplish more effective management of STD, therefore, the improvement of current social problems involving sexual openness, the pleasure-seeking industry and drug abuse should be achieved. (Korean J Dermatol 1998;36(5) . 836-843)

균상 식육종

노양수(Yang Soo Nho),최영자(Young Ja Choi),성호석(Ho Suk Sung),왕한영(Han Young Wang) 대한피부과학회 1987 대한피부과학회지 Vol.25 No.3

We report a case of 68--year-old male patient who was confirmed as d'emblee type of mycosis fungoides. The skin 1esions showed sharply rnargined multiple reddish brown coIarcd papules, ndules, and tumors on the groin, thign, abdomen, and neck. The microscopic findings showed the epidermotropism and pautrier's micruabscess in the epidermis, and the infiltration of atypical cells in the dermis. The electron micrascopic findings showed irregular contour of t:he nuclear mernbrane within atypical lymphocytes. Thc lesions were gradually diminished by superficial radiation therapy.

췌장염에서 발생한 결절성 지방괴사

박성욱 ( Sung Wook Park ),이학중 ( Han Young Wang ),왕정길 ( Hak Joong Lee ),왕한영 ( Jeong Kil Wang ) 대한피부과학회 1998 대한피부과학회지 Vol.36 No.2

Nodular fat necrosis is a rare and often overlooked sign of pancreatic disease. It is manifested as painful subcutaneous erythematous nodules, often found on the legs. We report a case of nodular fat necrosis associated with pancreatitis. The patient was a 14-year-old girl who presented with erythema nodosum-like tender subcutaneous nodules on both her lower extremities. The serum amylase and lipase levels were markedly elevated. The change of serum calcium and eosinophils were not so remarkable. Histopathological findings showed diffuse subcutaneous fat necrosis and ghost-like cells with thick shadowy walls and no nuclei. The lesions involuted gradually without any specific treatment and the underlying pancreatitis was followed up in the department of medicine. (Korean J Dermatol 1998;36(2): 346-349)

외음부에 발생한 한관종 2예

박준환(Joon Hwan Park),강효준(Hyo Jun Kang),왕한영(Han Young Wang),성호석(Ho Suk Sung) 대한피부과학회 1995 대한피부과학회지 Vol.33 No.1

We report two cases of vulvar syringorna in a 40-year-old women and a 28-year-old woman who had 2-3mm sized, brownish papules on both valvar areas an l-3rnm sized, yellow-brownish papules on both vulvar ares with yellowish milia-like lesion the surface, respectively. Microscopically the lesions revealed characteristic findings of syrinzoiza However the second case showed a small cystic duct in the papillary dermis, which is lineilly a stratified epithelium and filled with concenteric lamellae of keratin. (Kor J Dematol 1995; 33(1) 193-196)