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항암제 안티네오플라스톤 A10의 동족체합성 및 항암 활성
최보길(Bo Gil Choi),서희경(Hee Kyoung Seo),김옥영(Ok Young Kim),정병호(Bung Ho Chung),오인준(In Jun Oh),조원제(Won Jea Cho),천승훈(Seung Hoon Cheon),박민수(Min Soo Park),최상운(Sang Un Choi),이정옥(Chong Ock Lee) 대한약학회 1997 약학회지 Vol.41 No.3
Some analogs and their Mannich bases of Antineoplaston A10 (A10) were synthesized. Chemical yield for the 2-(or 3-)thienyl, benzol, and phenylpropionyl analogs were high but 1-naphthyl analog was synthesized in low yield. the Mannich bases formation of these analogs with morpholine went verywell compared to other bases. 1-Naphthyl, 4-nitrobenzoyl, and phenylpropionyl analogs of A10 showed weak in vitro activity but the other A10 analogs showed weaker or no activity at 10-1000mcg/ml. But their Mannich bases containing A10analogs showed good in vitro activity compared to simple A10 analogs.
항암제 안티네오플라스톤 A10 의 동족체합성 및 항암 활성
최보길,서희경,김옥영,정병호,오인준,조원제,천승훈,박민수,최상운,이정옥 전남대학교 약품개발연구소 1997 약품개발연구지 Vol.6 No.1
Some analogs and their Mannish bases of Antineoplaston A10 (A10) were synthesized Chemical yield for the 2-(or 3-)thienyl, benzoyl, and phenylproptonyl analogs were hight but 1-naphthyl analog was synthesized in low yield. The Mannish bases formation of these analogs with morpholine went very well compared to other bases. 1-Naphthyl, 4-nitrobenzoyl. and phenylpropiortyl analogs of A10 showed weak in vitro activity but the other A10 analogs shaved weaker or no activity at 10-1000 ㎍/㎖. But their Mannish bases containing A10 analogs showed good in vitro activity compared to simple A10 analogs.