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- 저자 : 오승열(Seung Youl Oh) (검색결과 5 건)
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기미에서 glycolic acid 화학박피술과 비타민 C 이온영동법의 치료 효과에 대한 비교 연구
김산(San Kim),오승열(Seaung Youl Oh),이승헌(Seung Hun Lee) 대한피부과학회 2001 대한피부과학회지 Vol.39 No.12
N/A Background:Glycolic acid has become popular and could provide an alternative choice to the current depigmenting agent. Vitamin C has been known as strong reducing agent and is supposed to retard synthesis of melanin pigment. Iontophoresis is emerging technologies capable of enhancing drug penetration through stratum corneum. Iontophoretic drug delivery may be easier following the chemical enhancer pretreatment Objective:We evaluated the efficacy of vitamin C-iontophoresis and glycolic acid peeling for melasma. Methods:34 patients with facial melasma were treated with 30% glycolic acid peeling or vitamin C-iontophoresis or 30% glycolic acid peeling combined with vitamin C-iontophoresis. The treatment was performed weekly for a period of 12 weeks. Iontophoresis was performed for 6 minutes under a constant direct current of 0.3-1.0 mA/cm2. The exposure time for glycolic acid were 2 minutes. Before and after 12 weeks treatment, the state of melasma was documented using by the modified version of Melasma Area and Severity Index(mMASI) and Mexameter MX16. We also measured vitamin C2-phosphate flux by in vitro iontophoresor and HPLC assay. Results:The mean scores of both mMASI and Mexameter MX16 after 12-week treatment were lower than those of baseline in all groups(p<0.05). Increasing vitamin C2-Phosphate concentration and increasing current density correlated with larger flux, and the flux in the first 40 minutes of the experiment appeared to be constantly larger than the steady-state flux during the period of the rest of the experiment, regardless of the current density. Pretreatment by peeling with glycolic acid did not significantly affect the vitamin C2-Phosphate flux through normal skin in vitro. Conclusion:Pretreatment by peeling with glycolic acid did not have a major impact on the vitamin C2-Phosphate flux in melasma patient. (Korean J Dermatol 2001;39(12):1356~1363)
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조정환(Jung Hwan Cho),이세희(Se Hee Lee),김희선(Hee Sun Kim),오승열(Seung Youl Oh) 한국약제학회 2000 Journal of Pharmaceutical Investigation Vol.30 No.2
We have studied the dissolution kinetics of two fast releasing tablets in four media, and the similarity of dissolution profiles was compared using 3 methods. Two of the methods were introduced from statistical algorithm of distance methods, which are maximum distance and Mahalanobis distance. The dissolution kinetics were also analysed using FDA method for similarity evaluation, and the results were compared with those obtained using the distance methods.
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Iontophoresis 를 이용한 NADPH 의 피부투과 및피부자극
이승연,오승열 숙명여자대학교 약학연구소 2004 약학논문집-숙명여자대학교 Vol.20 No.-
Nicotinamide Adenine Dinucleotide Phosphate (NADPH) has antioxidant effect in the body and thus decreases the symptoms of senility. The delivery of NADPH through skin is a formidable challenge due to its physical and chemical properties (such as rapid decomposition by oxidation, low partition coefficient in stratum corneum, high molecular weight and charge). The purpose of this work is to prepare a hydrogel patch system containing NADPH, and to study its in-vitro iontophoretic transport through hairless mouse skin. We have investigated two factors (concentration of NADPH and current density) that can affect the iontophoretic flux. The stability of NADPH in aqueous solution and the possible skin irritation by iontophoretic delivery of NADPH was also investigated. The results showed that, compared to passive flux, the total amount of NADPH transported increased by the application of cathodal current. Anodal flux was similar to passive flux. Flux increase was proportional to the concentration of NADPH in the donor solution and to the current density. Nearly 50 % of NADPH degraded during the experimental period in aqueous solution. The results of primary irritatation test showed no erythema or edema after iontophorsis. These results suggest that therapeutic amount of NADPH can be delivered through skin using iontophoresis, without any development of erythema or edema.
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이승연,여지선,김혜지,민혜란,오승열 숙명여자대학교 약학연구소 2004 약학논문집-숙명여자대학교 Vol.21 No.-
We have prepared hydrophilic karaya gum patches containing ketoprofen and studied some important factors which affect the transdermal flux of ketoprofen, as a first step to develop an iontophoretic transdermal patch system. The effect of penetration enhancer (propylene glycol monolaurate: PGML), short-time current treatment and continuous current on flux was studied. The effect of pH of the receptor solution and poly (L-lysine) (PLL) was also studied. PGML increased the passive flux markedly, and as the concentration of PGML in the matrix increased, passive flux increased. Iontophoretic treatment of skin (0.4 mA/cm²) for an hour increased the average passive flux more than two times, when the matrix contained no enhancer. It also increased the average passive flux further, when enhancer was incorporated into the matrix. Continuous iontophoretic transport showed unexpected result; the average flux at 0.2 mA/cm² was similar to that at 0.4 mA/cm², and was higher than that at 0.6 mA/cm². PLL increased the continuous iontophoretic transport at all current density, and the average flux was higher at 0.6 mA/cm² than at 0.4 and 0.2 mA/cm². Similar results were obtained when the receptor solution was changed to pH 4.0 buffer solution. These result demonstrate, that electro-osmotic flow is playing an important role in the flux of ketoprofen.
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NADPH의 안정화 및 이온토포레시스를 이용한 피부투과
신현택,이승연,오승열 숙명여자대학교 약학연구소 2005 약학논문집-숙명여자대학교 Vol.22 No.-
Nicotinamide Adenine Dinucleotide Phosphate (NADPH) has antioxidant effect in the body and thus decreases the symptoms of senility. The development of a transdermal delivery formulation for NADPH is a very difficult task, due to its rapid decomposition by oxidation, low partition coefficient into stratum corneum, high molecular weight and electrical charge at neutral pH in aqueous solution. The purpose of this work is to test several anti-oxidants as the stabilizing agent for NADPH in the aqueous formulation, and to study the effect of these agents on the in-vitro iontophoretic transport through hairless mouse skin. The stability of NADPH in aqueous solution with/without various antioxidants such as butylated hydroxy toluene (BHT), resveratrol, a-tocopherol and Vitamine C was studied. BHT an a-tocopherol (0.01 % w/w) exhibited minimal stabilizing effect, however resveratrol and vitamine C showed significant stabilizing effect. Stabilizing effect of vitamine C was proportional to the concentration in aqueous solution. Although vitamine C increased the stability ofNADPH significantly, it decreased flux of NADPH in a concentration dependent fashion, therapeutic amount ofNADPH can be delivered through skin using iontophoresis and These results suggest that, in order to develope a efficient iontophoresis formulation, it is important to choose a stabilizing agents which are not only potent in stabilizing effect but also not competitive for the delivery of NADPH.
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