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Paraquat 독성에 미치는 Dicumarol과 Allopurinol의 병합 투여 효과
송명화,정미숙,오순식,박재윤,차종희 조선대학교 1995 The Medical Journal of Chosun University Vol.20 No.1
Despite intensive investigation into paraquat toxicity, neither the final cytotoxic mechanism nor a clinically useful antidote has been discovered. The mechanism of paraquat cytotoxicity is also debatable, but it is generally accepted that a redox reaction occurs between reduced paraquat and molecular oxygen. The intracellular reduction of paraquat occurs by various enzymes, such as DT-diaphorase, xanthine oxidase and glutathione reductase. In present study, we investigated that the effects of allopurinol, a xanthine oxidase inhibitor, and dicumarol, a DT-diaphorase inhibitor, in paraquat-intoxicated rats. The survivals of paraquat-intoxicated rats were increased by allopurinol treatment compared to paraquat-treated control rats , but not effected by dicumarol treatment. The activity of xanthine oxidase in the liver of allopurinol-treated rats was decreased and DT-diaphorase activity in liver of dicumarol treated rats was also decreased compared to normal control rats. The contents of glutathione in liver of paraquat treated rats was decreased but in paraquat+allopurinol treated rats, the decrements of glutathione contents was reduced but in paraquat+dicumarol treated rats, liver glutathione level was not changed compared to paraquat-treated rats. These results suggest that paraquat toxicity maybe reduced by administration of allopurinol but dicumarol did not have such effects .