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추출농도에 따른 오미자 및 구기자를 첨가한 한방약술의 품질특성
오성천 한국응용과학기술학회 2019 한국응용과학기술학회지 Vol.36 No.1
In this study, the following is the result of measuring the quality characteristics of herbal wine and the active inhibition of Glutathione S-transferase in order to measure the release of physiological active substances according to the concentration of extracts. The pH level of herbal wine was 4.4, up from 3.9 before fermentation. These changes are attributed to fermentation and organic acids during alcoholic fermentation. The acidity of herbal wine was 0.55%, about six times higher than the pre-fermentation control of 0.09%. These results show that organic acids are used for flavor formation, ether, in combination with alcohol. The inhibitory activity of glutathione S-transferase were 5.1±0.31 in herbal wine 15%, 6.5±0.6 in herbal wine 20%, 7.6±0.6 in herbal wine 25%, 8.4±0.2 in herbal wine 30% and 9.7±0.7 in herbal wine 35%. As the extract concentration was increased the inhibitory activity of glutathione S-transferase were significantly increased (<0.05). 본 연구에서는 한약재의 활용도를 높이기 위한 연구로 추출물 농도에 따른 생리활성물질의 용출량을 측정하기 위해 한방약술의 품질 특성과 Glutathione S-transferase의 활성 저해능을 측정한 결과는 다음과 같다. 한방약술의 pH결과는 4.4로 발효 전의 대조구 3.9보다 증가하였다. 이러한 변화는 알코올 발효과정 중 발효부산물 및 유기산 때문으로 사료된다. 한방약술의 산도는 0.55%로 발효 전의 대조구 0.09%보다 약 6배 증가하였다. 이런 결과는 유기산이 알코올 등과 결합하여 ester와 같은 향미 형성 등에 이용되는 것을 알 수 있다. 한방약술 15%의 glutathione S-transferase의 활성 저해능 5.1±0.3, 한방약술 20%는 저해능 6.5±0.5, 한방약술 25%는 7.6±0.6, 한방약술 30%는 8.4±0.2, 최대 농도인 35%에서의 저해능은 9.7±0.7로 나타내었다. 추출 농도별로 glutathione S-transferase의 활성 저 해능은 통계학적으로 유의한 차이가 있음을 보였다 (p<0.05).
Impaired Perception of Emotional Expression in Amyotrophic Lateral Sclerosis
오성일,오기욱,김희진,박진석,김승현 대한신경과학회 2016 Journal of Clinical Neurology Vol.12 No.3
Background and PurposezzTe increasing recognition that defcits in social emotions occur in amyotrophic lateral sclerosis (ALS) is helping to explain the spectrum of neuropsychological dysfunctions, thus supporting the view of ALS as a multisystem disorder involving neuropsychological defcits as well as motor defcits. Te aim of this study was to characterize the emotion perception abilities of Korean patients with ALS based on the recognition of facial expressions. MethodszzTwenty-four patients with ALS and 24 age- and sex-matched healthy controls completed neuropsychological tests and facial emotion recognition tasks [ChaeLee Korean Facial Expressions of Emotions (ChaeLee-E)]. Te ChaeLee-E test includes facial expressions for seven emotions: happiness, sadness, anger, disgust, fear, surprise, and neutral. ResultszzTe ability to perceive facial emotions was signifcantly worse among ALS patients performed than among healthy controls [65.2±18.0% vs. 77.1±6.6% (mean±SD), p=0.009]. Eight of the 24 patients (33%) scored below the 5th percentile score of controls for recognizing facial emotions. ConclusionszzEmotion perception defcits occur in Korean ALS patients, particularly regarding facial expressions of emotion. Tese fndings expand the spectrum of cognitive and behavioral dysfunction associated with ALS into emotion processing dysfunction.