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Acetylcholine에 의한 개구리 복직근 수축작용에 미치는 Morphine의 영향
오남휴,한종현,은홍배 전북대학교 의과학연구소 1984 全北醫大論文集 Vol.8 No.1
Effect of morphine on the contraction of frog rectus abdominis muscle evoked by acerycholine(ACh) was studied in this experiment. 1. Human serum diminished the effect of Ach on the contractile force of frog rectus abdominis muscle. 2. Morphine weakened the contractile force of the skeletal muscle evoked by ACh. 3. Morphine inhibited the effect of human serum on the contractile action of ACh. 4. In vitro experiment, morphine decreased cholinesterase activity of human serum. From the above results, it is suggested that morphine has dual action on skeletal muscle, i, e. potentiating action by inhibition of cholinesterase and inhibitory action by direct inhibition of skeletal muscle.
家猫에서 Apomorphine 의 心脈效果에 미치는 Opiate系의 影響
우영중,오남휴,채수완,곽용근,조규박 의과학연구소 1990 全北醫大論文集 Vol.14 No.3
The purpose of this study was to evaluate the cordiovascular effects of apomorphine and influence of opiate system on the action of apomorphine in cat. The resurlts abtained were as follows: 1. Intravenous or intraventricular apomorphine elicited dose-related hypotension and bradycardia. 2. Theses hypotensive and bradycardiac effect of apomorphine were blocked by intravenous naloxone or methylnaloxone but were not influenced by intraventricular methylnaloxone. 3. Intravenous SCH23390 and/or sulpiride reduced the cardiovascular effects of intravenous apomorphine, naloxone did not affect the blocking effects of sulpiride, but potentiated the effect of SCH23390. 4. While these blocking agents inhibited the bypotensive and cardiac slowing effects of the drug, intravenous naloxone did not affect the cardiovascular effects of apomorphine in the presence of prazosin, propranolol, hexamethonium or atropine. 5.However, naloxone reduced the hypotensive effect of intravenous apomorphine without affecting the heart rate in the vagotomized cats. 6.Intravenous morphine diminished the hypotensive and bradycardiac effects of apomorphine, but intraventricular morphine did not affect the cardiovascular effects of apomorphine. From the above results, it is suggested that opiate system modifies the apomorphine-induced hypotension at the presynaptic site of sympathetic ganglia and modulates the cardiac slowing effect at sympathetic ganglia as well as at central parasymapathetic neuron.
곽용근,오남휴,김용기,채수완,조규박 의과학연구소 1990 全北醫大論文集 Vol.14 No.2
This study was purposed to evaluate the cardiovascular effect of RU24213 and the interaction between DA_1 and DA_2 activity in anesthetzed cat. The results obtained were as follows; 1. Intravenous or intraventricular RU24213 elicited dose-related hypotension and bradycardia. 2. The hypotensive effect of intravenous Ru24313 was blocked not by intravenous SCH23390 but by intravenous sulpiride, and the bradycardiac effect of intravenous RU24313 was blocked by intravenous SCH23390 or intravenous sulpiride. 3. The cardiovascular effect of intravenous RU24313 was blocked by intravenous phenoxybenzamine, propranolol, hexamethonium or atropine, and bilateral vagotomy did not ihhibit the htpotensive effect of intravenous RU2413 but inhibited bradycardiac effect of the drug. 4. The hypotensive and bradycardisc effects of intravenous RU24213 were inhibited by pretreatment with SKF38393. From the above results. it is suggested that hypotensive effect of RU24313 was developed via central and peripheral dopamine receptors, while bradycardiac effect of the drug was related to the peipheral of DA_1 receptor inhibits the action of DA_2 agonist in cardiovascular system of cat. (Key Wards: RU24213, dopamine D_1, dopamine D_2 receptor, cardiovascular ststem, cat)