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이형종,서영욱,이민용,이태성,신혜영,여준규,차순도 대한부인종양 콜포스코피학회 1993 Journal of Gynecologic Oncology Vol.4 No.3
Thirteen patients with malignant germ cell tumors of the ovary have been treated with a combination chemotherapy. The age of the patients ranged from 11 to 50 years and there was no history of radiation therapy of chemotherapy except operation, Stage distributions are as follow ; 2 pstients are stage IV, 3 are stage II and remained 8 are stage I. 4 patients with immature teratoma and 2 patients with mixed germ cell tumor received VAC chemotherapy, as primary therapy, and among them 1 lost to follow up but remained 5 cases live without evidence of disease 39 to 83 months. There were 3 patients with endodermal sinus tumor and 1 received VAC and remained 2 received PVB as primary chemotherapy, Of them 1 died of disease after 9 months of oyeration and the other 2 live now with no evidence of disease. There were 2 patients with dysgerminoma and 2 with primary ovarian choriocarcinoma. 1 patient with dysagerminoma and 1 wit choriocarcinoma were died because of chemotherapy toxicity, 1 patient with dysagerminoma, who refused further ehemotherapy after l course of chemotherapy, died of progressive disease. l patient wit choriocarcinoma now live well without evidence of disease at 35 months. The combination chemotherapy using VAC or PVB regimen represents an effective treatment for malignant. germ cell tumors of the ovary and reveals moderate toxicity.