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양원규(Won Kyu Yang),박원일(Won Il Park),고덕성(Duck Sung Ko),김선희(Sun Hee Kim),김은경(Eun Kyung Kim),이호준(Ho Joon Lee) 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.10
N/A Thanatophoric dysplasia (TD) is a sporadic lethal type of skeletal dysplasia featuring micromelia, decreased thoracic dimension and macrocephaly. To date, several kinds of mutation in fibroblast growth factor receptor 3 (FGFR3) has been identified in TD. We experienced a case of TD type I and underwent sequencing of the exon 7, 10 and the stop codon of FGFR3 to identify the type of mutation. TDI was diagnosed by the prenatal ultrasound at 25 weeks of gestation. The pregnancy was terminated and the diagnosis was confirmed by radiological and histologic examinations. The genomic DNA was extracted and the sequences of the exon 7, 10 and the stop codon of FGFR3 were amplified by PCR. The sequencing was performed for the each PCR products by dideoxyterminator method. The nucleotide transition from G to T was found in the nucleotide 1108, which is a part of the transmembrane domain, exon 10. To date, only one type of mutation (nucleotide 742) in the FGFR3 was identified in TD1 among Asian. This case firstly reveals the mutation of FGFR3 other than mutation at nucleotide 742 in TD1.
임신 중기 triple marker screenig test의 다운 증후군의 예측성에 대한 고찰
한경철(Kyoung Chul Han),김대운(Dae Woon Kim),정수미(Su Mi Jeong),양원규(Won Kyu Yang),박철범(Chul Beom Park),신봉규(Bong Kyu Shin),신정환(Jeong Hwan Shin),홍서유(Seo You Hong) 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.9
본 연구에서는 임신 중기에 행해지는 산전 검진인 triple marker screening test의 다운 증후군 예측성에 대한 신뢰도에 대해 고찰을 하고자 하였으며 구체적으로, 첫째, 선별 검사상 양성인 산모의 경우 향후 그 임신의 결과를 분석하였고, 둘째, 분만된 신생아에서 염색체 이상을 보인 경우 그 신생아의 임신시에 시행한 선별검사와의 상관관계를 비교 분석하였다. 검사를 시행한 산모 3700명중 67명(1.81%)이 검사 양성, 67명중 1명이 실제로 다운 증후군 이었으며, 검사 음성은 3633명(98.18%)이었고 이중에서 4 명이 염색체 이상으로 분만되었으며, 4명중 다운 증후군은 2명이었다. 분석 결과 본원에서 시행한 다중 혈청 지표 선별 검사의 다운 증후군에 대한 민감도는 33.3% 특이도는 98.2%로 문헌에서 보고 되고 있는 결과와 비교 해볼 때 상당히 낮은 민감도를 나타냈다. 따라서 이에 대한 원인에 대해 고찰해보았다. Objective: To assess the reliability of triple marker screening test in midtrimester pregnancy for fetal Down syndrome. Methods: From October 1, 1996 to May 31, 1998 at Nowon Eulji Hospital, 3700 Pregnant women underwent serum tiple marker screening for Down syndrome during 15-20weeks of gestational age. The results of serum triple marker screenig tests for Down syndrome and the outcomes of pregnancies were retrospectively assesed. Results: Sixty seven of 3700 cases(1.81%) were positive in screening test, and 3633(98.18%) cases were negative. Among 67 cases of positive screening test , 1 case(1.49%) was diagnosed as Down syndrome. Among 3633 cases of negative screening test, 4 cases(0.1%) were diagnosed as chromosomal abnormalies postnatally. Two of these 4 cases of chromosomal abnormalies were Down syndrome. Conclusion: With this results, sensitivity of triple marker screeing test for Down syndrome is very low as 33.3%. In order to increase the sensitivity, some compensatory adjustment is required in triple marker screening test.
낮은 자기 통제력이 경찰 문제행위에 미치는 영향 : 기회요인의 조절효과 분석
이수창 ( Lee Soo-chang ),장철영 ( Jang Cheol-yeung ),양원규 ( Yang Won-kyu ) 한국융합과학회 2016 한국융합과학회지 Vol.5 No.4
Purpose: This study is to investigate a moderated effect of opportunity in the causal relationship between low self-control and police misconduct. In line with this perspective, this study includes impulsivity, simple task, risk seeking, physical activity, self-centered, and temper as variables for low self-control and absence of supervision and proximity to motivated offender as ones for opportunity in predicting effects on police misconduct. Method: This study employs a survey questionnaire to evaluate the moderated effect of opportunity in the causal relationship that low self-control has influence on police misconduct. A 39-item survey questionnaire was administered to 400 police officers in Daegu metropolitan city and Gyeongsangbuk-Do province. The research data are analyzed by using four statistical methods: factor analysis, reliability analysis, correlation analysis, and moderated multiple regression analysis. Conclusion: As the result of analysis, low self-control and opportunity has a positive effect on police misconduct. Absence of supervision of opportunity has a moderated effect in the causal relationship between low self-control and police misconduct, proximity to motivated offender is not. The analytical results show that police organizations should establish alternatives for enhancing supervision on police officers` works without violating privacy.