http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : 양우익 ( Yang U Ig ) (검색결과 4 건)
- 무료
- 기관 내 무료
- 유료
-
원발성 피부 CD30 양성 대형세포 림프종 8예에 대한 임상 및 조직학적 관찰
김유찬 ( Kim Yu Chan ),이민걸 ( Lee Min Geol ),박상건 ( Park Sang Geon ),양우익 ( Yang U Ig ),서기석 ( Seo Gi Seog ) 대한피부과학회 2003 大韓皮膚科學會誌 Vol.41 No.11
N/A Background : Although several cases of primary cutaneous CD3O-positive large cell lymphoma have been reported, immunohistochemical study on the tumor has not been reported in Korea. Objective : Our purpose is to evaluate the clinicopathologic and immunohistochemical findings of primary cutaneous CD3O-positive large cell lymphoma. Methods : An immunohistochemical study was performed on paraffin sections of 8 primary cutaneous CD3O-positive large cell lymphoma using CD3, CD45RO, CD45, CD2O, CD3O, and epithelial membrane antigen(EMA). Results : 1. Primary cutaneous CD3O-positive large cell lymphoma occurred equally on males and females. The average age of the patients was 49. The lesion occurred most commonly as nodules on the extremities. Spontaneous regression occurred in 3 cases. The most common treatment was radiotherapy. 2. Histopathologically, 2 of 8 cases showed epidermal hyperplasia with intraepidermal neutrophils. Epidermotropism was found focally in 1 case. Inflammatory cells were present at the periphery of the lesions in 2 cases, but they were admixed with the large atypical cells in 1 case. Tumor cells invaded the subcutaneous tissue in 4 of 6 cases. 3. Immunohistochemically, the large anaplastic cells showed CD3O positivity. Tumor cells in all cases showed positivity for CD3, CD45RO, and CD45, but negative for CD2O. Tumor cells stained with EMA in 1 of 6 cases. Conclusion : Primary cutaneous CD3O-positive large cell lymphoma showed immunophenotype of T-cell lymphoma. It showed some clinicopathologic features of lymphomatoid papulosis, which suggests that both entities represent 2 ends(malignant and benign) of a spectrum of CD3O-positive lymphoproliferative disorders. Therefore, for the diagnosis of primary cutaneous CD3O-positive large cell lymphoma, all clinicopathologic and immunohistochemical findings should be considered together. (Korean J Dermatol 2003;41(11) : 1471∼1477)
-
천은영 ( Cheon Eun Yeong ),김세훈 ( Kim Se Hun ),양우익 ( Yang U Ig ),이민걸 ( Lee Min Geol ) 대한피부과학회 2003 大韓皮膚科學會誌 Vol.41 No.12
N/A Background: Kaposi`s sarcoma (KS) is a mesenchymal tumor involving blood and lymphatic vessels. Viral oncogenesis by human herpesvirus 8 (HHV8) and cytokine-induced growth together with some state of immunocompromise represent important conditions for this tumor to develop. Objective: The purpose of this study was to document the clinical and histopathological features of KS in Korea. Methods: The medical records and histopathologic slides of patients with KS diagnosed at Yonsei University Medical Center from January, 1992 to March, 2003 were reviewed. We used immuno-histochemical stains for HHV8 to determine whether HHV8 is present in KS. Results: 1. Among the 21 patients, classic KS was found in 7, acquired immunodeficiency syndrome (AIDS)-associated KS in 3, and introgenic, immunosuppressive KS in 11. 2. Classic and introgenic KS most often have a preference for the lower extremities, while the upper body in AIDS-KS. Mucosal involvement and systemic organ involvement could be detected in AIDS-KS. 3. Immunohistochemical stains for HHV8 were positive in 100% with classic KS and AIDS KS, and 90.9% with immunosuppressive KS. 4. Classic KS responded well to local therapy and showed indolent course. Iatrogenic, immunosuppressive KS generally regressed after reduction or cessation of immunosuppressive drug therapy, but some of them showed resistance to therapy. For AIDS-KS, no systemic treatments have been shown to prolong survival. Conclusion: Because classic KS and iatrogenic, immunsoupressive KS generally have a benign coures, cautions are taken not to overtreat them. However, some cases of organ transplantation associated KS have an aggressive coures, prompting us to consider active treatments to save transplanted organ. (Korean J Dermatol 2003;41(12):1603~1611)
-
-
선근종에서 aromatase cytochrome P450의 표현 양상
이윤정 ( Lee Yun Jeong ),김지영 ( Kim Ji Yeong ),박영세 ( Park Yeong Se ),김용민 ( Kim Yong Min ),장진범 ( Jang Jin Beom ),조동제 ( Jo Dong Je ),김재욱 ( Kim Jae Ug ),양우익 ( Yang U Ig ) 대한산부인과학회 2004 Obstetrics & Gynecology Science Vol.47 No.3
목적 : 본 연구에서는 선근종과 정상 자궁의 내막 조직에서 여성호르몬의 합성에 관여하는 aromatase의 활성도를 알아보고자 항P450 arom 항체를 이용하여 P450 arom의 면역조직화학적 표현 양상을 관찰하였다. 연구 방법 : 2002년 5월부터 2003년 10월 사이에 자궁 적출술을 시행 받은 환자 중 조직병리학적으로 선근종으로 확진된 23명을 실험군으로, 자궁 경부 질환이나 비기능성 자궁 출혈 등의 소견으로 소파술이나 자궁적출술로 얻은 자궁 내막을 정상 자궁의 내막으로 간주하여 17명의 환자를 대조군으로 관찰하였다. 각각의 동결 절편한 조직들에서 항P450 arom 항체를 이용한 면역조직화학 염색을 시행하였다. 결과 : P450 arom은 내막 조직 (82.6%)와 일부 선근종 환자의 정상 자궁 내막 (23.5%)에서 양성 반응이 나타났다. 정상 자궁 내막 조직의 선상피세포와 기질에서는 P450 arom의 면역반응이 나타나지 않았다. 결론 : 이상의 결과에서 본 연구는 선근종의 자궁 내막 조직에서 P450 arom의 면역조직 화학 염색을 통해 aromatase의 활동이 있다는 것을 확인하고 선근종이 없는 자궁 내막에서는 aromatase 활동이 나타나지 않음을 알 수 있었다. Objective : To determine whether local estrogen production takes place in adenomyosis and in normal endometrium. Methods : The study included 23 cases of adenomyosis and 17 cases of normal uterine endometrium obtained through hysterectomy or curettage at Kangnam Cha Hospital. The frozen tissue specimens were examined by immunohistochemistry using P450 arom. Results : P450 arom was immunolocalized exclusively in the cytoplasm of glandular cells of adenomyotic tissue. However, no apparent staining was observed in stromal cells. Aromatase was expressed in the ectopic glands (82.6%), but also in the eutopic endometrium of patients with adenomyosis (23.5%). In the case of normal endometrium, P450arom was not detected. Conclusion : These results suggest that the aromatase activity is correlated to the pathophysiology of adenomyosis.
KCI연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
