Morin이 benzo(k)fluoranthene에 의한 유방암 세포 MCF-7의 CYP1A1 유전자 발현 조절에 미치는 영향

양소연,김여운,신윤용,Yang, So-Yeon,Kim, Yeo-Woon,Sheen, Yhun-Yhong 한국환경성돌연변이발암원학회 2004 한국환경성돌연변이·발암원학회지 Vol.24 No.4

We investigated the effect of dietaty flavonoid, such as CYP1A1 promoter activity, 7-ethoxyresorufin-O-deethylase(EROD) activity and CYP1A1 mRNA expression induced by benzo(k)fluoranthene(B(k)F) in MCF-7 cells. Based on the three criteria of frequency of occurrence in the environment, toxicity and potential exposure to humans, B(k)F is one of the top-listed PAHs. We found that B(k)F significantly up-regulates the level of CYP1A1 promoter activity, EROD and CYP1A1 mRNA. When cells were treated with morin alonem, it was not changed that EROD and CYP1A1 mRNA, compared to that of control. However, morin inhibited the B(k)-induced CYP1A1 prompter activity and mRNA level at high concentration. But morin exhibited stimulatory effects B(k)F-induced CYP1A1 promoter activity and mRNA level at low concentration. Overall, results from these studies demonstrate morin might interfere the action of B(k) with AhR system to stimulate CYP1A1 gene expression. CYP1A1 is known to be inducible by xenobiotic compouds such as polyciclic aromatic hydrocarbons(PAHs) and 2,3,7,8-tetrachloro-dibenzo-p-dioxin(TCDD). These chemicals have been identified worldwide and can have a significant impact on the human health and well being of human and wildlife. Given these issues, the detection and quantification of these chemicals in biological, environmental and food samples is important.

사람 유방암 세포 MCF-7에서 Benzo(k)fluoroanthene과 genistein이 CYP1A1 유전자 발현에 미치는 영향

양소연,민경난,신윤용,Yang, So-Yeon,Min, Kyung-Nan,Shin, Yhun-Yhong 한국환경성돌연변이발암원학회 2004 한국환경성돌연변이·발암원학회지 Vol.24 No.3

CYP1A1 is known to be inducible by xenobiotic compouds such as polyciclic aromatic hydrocarbons(PAHs) and 2,3,7,8-tetrachloro-dibenzo-p-dioxin(TCDD). These chemicals have been identified worldwide and can have a significant impact on the human health and well being of human and wildlife. Given these issues, the detection and quantification of these chemicals in biological, environmental and food samples is important. First, we investigated the effect of on CYP1A1 promoter activity, 7-ethoxyresorufin-O-deethylase(EROD) activity and CYP1A1 mRNA expression induced by benzo(k)fluoranthene(B(k)F) in MCF-7 cells. We found that B(k)F significantly up-regulates the level of CYP1A1 prompter activity, EROD and CYP1A1 mRNA. When cells were treated with genistein, it was not changed that EROD and CYP1A1 mRNA, compared to that of control. However, genistein inhibited the B(k)F-induced CYP1A1 promoter activity and mRNA level at high concentration. Furthermore, in this study, effects of HDAC(histone deacetvlase) inhibitors on human prostate cancer cells proliferation were examined. HC-toxin, SAHA and TSA inhibited cell proliferation in PC3 cells. A novel HDAC inhibitor, IN2001 also suppressed the growth of PC3 cells. And IN2001 and SAHA increased S phase and G2/M phase at 12 hrs treatment but cells were arrested G0/G1 phase at 45 hrs treatment. The HC-toxin treatment for 24 hrs and 48 hrs increased G0/G1 at low concentration ($0.1\mu\textrm{m}$) but increased G2/M at more than concentration of $1\mu\textrm{m}$. TSA increased G2/M phase. These findings height the possbility of developing HDAC inhibitors as potential anticancer therapeutic agents for the treatment of prostate cancer.

Daidzein이 benzo(k)fluoranthene에 의한 사람 유방암 세포 MCF-7의 CYP1A1 유전자 발현 조절에 미치는 영향

양소연,신윤용,Yang, So-Yeon,Sheen, Yhun-Yhong 한국환경성돌연변이발암원학회 2004 한국환경성돌연변이·발암원학회지 Vol.24 No.4

CYP1A1 is known to be inducible by xenobiotic compouds such as polyciclic aromatic hydrocarbons(PAHs) and 2,3,7,8-tetrachloro-dibenzo-p-dioxin(TCDD). These chemicals have been identified worldwide and can have a significant impact on the human health and well being of human and wildlife. Given these issues, the detection and quantification of these chemicals in biological, environmental and food samples is important. We investigated the effect of dietaty flavonoid, such as CYP1A1 promoter activity, 7-ethoxyresorufin-O-deethylase(EROD) activity and CYP1A1 mRNA expression induced by benzo(k)fluoranthene(B(k)F) in MCF-7 cells. Based on the three criteria of frequency of occurrence in the environment, toxicity and potential exposure to humans, B(k)F is one of the top-listed PAHs. We found that B(k)F significantly up-regulates the level of CYP1A1 promoter activity, EROD and CYP1A1 mRNA. when cells were treated with daidzein inhibited the B(k)-induced CYP1A1 prompter activity and mRNA level at high concentration. But daidzein exhibited stimulatory effects B(k)F-induced CYP1A1 promoter activity and mRNA level at low concentration. Overall, results from these studies demonstrate flavonoids might interfere the action of B(k) with AhR system to stimulate CYP1A1 gene expression.

법적 논증에서 서사(Narrative)의 기능

양소연(Grace Soyun Yang) 한국법학원 2020 저스티스 Vol.- No.177

서사(narrative)란 개별적인 사건들이 서로 합리적인 관련성을 가지는 방식으로 배열되어 전체를 구성하는 방식 또는 구조를 말한다. 법적 논증에서 모든 당사자는 자신의 시각에서 구성한 서사적 사실관계를 바탕으로 주장을 개진한다. 당사자가 제시한 서사로부터 진술의 일관성, 사건의 개연성 등을 파악할 수 있으므로, 법적 논증에서의 서사는 당사자의 입장에서는 설득과 수사의 기능을, 결론을 내리는 입장에서는 실체적 사실관계 발견과 증명력판단의 기능을 할 수 있고, 결과적으로 개별 사안에서 구체적 타당성을 확보하는 데 기여한다. 본고에서는 공감과 법감정, 서사가 법적 논증에 미치는 영향에 관하여 주로 미국에서의 기존 연구들에 비추어 그 이론적 가능성을 검토하고, 나아가 우리 재판실무에서 서사가 작용할 수 있는 영역과 대표적인 예를 살펴본다. Narrative refers to a structure of storytelling through which a narrator purposefully arranges a series of events in a way that individual events can logically correlate to each other. Legal reasoning is an act of speech where litigants use rhetorical strategies to effectively persuade the judge or the jurors, often by telling stories reconstructed from their own perspective. Examining the narrative structure in a legal argument reveals the probability of events and the credibility of the speaker, leading to a more equitable conclusion. This article examines the legitimacy of narrative legal reasoning by reviewing some relevant literature in American legal narratology and legal theory in general, then suggests the possibility of narrative legal reasoning in Korean court proceedings.

건강한 학교 실내환경계획을 위한 자연요소 도입방안에 관한 연구 - 숲 이미지 분석을 중심으로 -

양소연(Yang, So-Yeon),이태경(Lee, Tea-Kyung) 대한건축학회 2021 대한건축학회 학술발표대회 논문집 Vol.41 No.2

The purpose of this study was to analyze students’ satisfaction with school environment and school life to derive problems with current school life and environment. In order to introduce natural elements to the school’s indoor environment, preferences, needs, moods of hope, places of hope, and reasons for need were investigated and analyzed for natural elements that could be introduced into the school indoor environment. The preference evaluation results for natural elements applicable to the interior were in the order of light, plants, and Soil and Stone. But Each natural element was evaluated differently in its preferred way of expression. It was also important to consider which natural elements were introduced indoor, but it was also important to consider the method of introducing each natural element.

거리 예술을 통해 본 정치적 주체화: 제이알(JR)의 얼굴 사진 프로젝트를 중심으로

양소연(So yeon Yang) 강원대학교 산학협력단 사회통합연구센터 2022 사회통합연구 Vol.3 No.1

2000년대 초반부터 거대 인물 초상 사진을 거리에 전시하는 프로젝트를진행하고 있는 제이알(JR)은 평범한 개인을 정치 담론 위로 끌어올리는 시민참여적 거리 예술을 펼치고 있다. 특정 직업, 계층, 연령, 성별 등 집단의정체성으로만 이해되던 개인의 얼굴을 거대 초상으로 극대화함으로써 대중의 일원일 뿐이었던 개인을 개성을 가진 주체로 드러나게 한다. 이러한 제이알의 작업은 익명으로 존재하던 대중이 예술 행위를 통해 자신을 드러내고담론의 주체가 될 수 있음을 보여주는 사례로서 랑시에르의 미학 정치의주요 개념인 정치적 주체화와 맞닿아 있다. 본 연구는 제이알의 얼굴 사진프로젝트 사례를 통해 거리 예술이 갖는 실천적 함의를 주체화 개념을 통해살펴보고자 한다. 랑시에르는 정치를 주체들의 문제 혹은 주체화 양식들의문제라 언급하며 평범한 개인들의 정치적 주체화를 현대 사회의 정치적 실천방안으로 제시한다. 제이알의 작품에 등장하는 개인들은 집단의 정체성이나계급성 등 자신에게 부여된 의미를 탈피하거나 전복시키는 경험을 통해 특정정체성을 가진 집단의 일원이 아닌 고유한 개성을 가진 존재로 사회에 목소리를 낸다. 이는 랑시에르가 말한 정치적 주체화 과정의 사례로서 예술을통한 정치, 예술이 갖는 실천적 속성을 보여준다. Since the early 2000s, JR has been working on a project to display portraits of giant figures on the street and engaging in citizen-participatory street art projects that make ordinary individuals express their voices on political discourses. JR take pictures of anonymous citizens and print out them in huge size. By showing individual's face pictures in the street, he tries to make people recognized as a subject who has its own personality and experiences while they usually have been only understood as a group identity, such as a specific occupation, class, age, and gender. JR's work is in contact with Rancière's aesthetic politics as an example of the politics of visibility in which the anonymous public reveals themselves through artistic acts and becomes the subject of discourse. In accordance with Rancière's discussion referring to politics as a problem of subjects or a problem of subjectivization styles, this study analyze characteristics of JR's artistic activity as a new aesthetic practice case that changes everyday life, JR uses his portrait projects as a strategy to illuminate the lives of marginalized or distorted communities. It seeks to discover the political implications of street art activities by viewing it as a process of political subjectivization through the subversion of group identity.

도시 예술의 미학적 실천 : 가상현실 예술 프로젝트 사례를 중심으로20)

양소연(Yang, So-Yeon) 지역사회학회 2022 지역사회학 Vol.23 No.1

이번 연구는 거리라는 일상의 공간에서 펼쳐지는 도시 예술이 자본주의 경제 체계의 획일성과 동일성이 지배하는 도시에 다양한 변화를 일으키고 있다고 보고, 디지털 미디어 기술과 결합한 도시 예술 사례들이 갖는 실천적 속성을 분석하고자 한다. 들뢰즈와 가타리, 그리고 랑시에르는 예술이 갖는 실천적 속성에 주목하며 미학은 곧 정치일 수밖에 없다고 주장한다. 미학 혹은 예술이란 기존의 권력 관계 안에서 구조화된 고정된 사유의 틀을 벗어나는 일일 수밖에 없고, 따라서 예술은 본질적으로 정치와 다르지 않다고 본 것이다. 일상의 삶이 이루어지는 거리에서 만나게 되는 도시 예술이라는 미학적 행위는 거리를 걷는 사람들로 하여금 효율적 노동의 공간 구획이라는 기호로 기입된 근대의 도시 공간을 낯설고 이질적으로 감각하게 함으로써 사유와 행동에 변화를 일으킨다. 또한 오감을 활용한 체험을 특징으로 하는 가상현실 기술이 적용된 예술은 시공간이라는 물리적 한계를 뛰어넘어 적용되는 예술로서 도시의 삶을 기존의 의미체계를 넘어 새롭게 사유하고 실천할 수 있는 계기를 마련해 준다. 도시 예술은 언어의 재현 체계로 규정되지 않는 기호로서 끊임없는 의미생성을 가능케 할 뿐 아니라, 디지털 기술과의 결합을 통해 예술과 일상의 경계, 작가와 관객의 분할, 그리고 예술 향유와 사회적 참여의 이분법적 분리를 뛰어넘어 예술을 통한 사회 변화를 일상의 공간인 거리에서 실천하고 있다. It is criticized that the principle of uniformity and identity increasingly affects all aspects of lives in this capitalist society and causes various social problems. In this situation, urban art drives social changes by providing the inspiration for creative thinking and acting, and plays an important role in fighting social challenges. This study analyze the practical implications of aesthetics from urban artworks, and finds out a capability of urban art to make a social change in everyday lives and encourage ordinary people to engage in social action. Urban art as an art form usually displayed on the streets or on the building walls inevitably reflect everyday lives of the cities. Artworks applying virtual reality technologies enable people to feel the world with all human senses and provide opportunities to think and practice city life in a new way beyond the existing meaning system. Urban art is a sign that is not defined as a system of representation of language, and not only enables the continuous creation of meaning, but also break the boundary between art and daily life, the division between the artist and the audience, and the dichotomy between the enjoyment of art and social participation. Virtual art practices not only show the potential of art as a new social engagement activities but also make it possible to forecast how art and technology can play an important role in making a better world as they stimulate people’s creativity.

바이오필리아 이론에 기초한 빛 환경 평가 연구

양소연(Yang, So-Yeon),이태경(Lee, Tae-Kyung) 한국주거학회 2016 한국주거학회 학술대회논문집 Vol.2016 No.4

The purpose of study developing Development evaluation methods of light environment for indoor of middle school based on ‘Biophilia’. This study is mainly based on literary review and survey research. To construct structural questionnaire based on ‘Light and Space’ of Biophilic Design for well being lighting environmental evaluation. We construct structural questionnaire that have 10 evaluation factors and 60 detail evaluation items to evaluate lighting environment for indoor of middle school based on biophilia theory. To survey students’ subjective evaluation, the participant of study has been selected with the total number of 232 middle school students. The data were analyzed using Multiple Regression Analysis by IBM SPSS statistics 21. The results of light environmental evaluation were factor 3,6,8,9 was lower than others. This study was designed to suggesting an evaluation method of light environment of the school. Biophilia theory said when 10 evaluation factor are in harmony, light environment can be well-being. So, factor 3,6,8,9 that are important elements to increase the satisfaction of lighting environment are consider carefully for the plan of indoor lighting environment.

시간대를 고려한 SHAP 기반의 신용카드 이상 거래 탐지

양소연 ( Soyeon Yang ),임유진 ( Yujin Lim ) 한국정보처리학회 2023 한국정보처리학회 학술대회논문집 Vol.30 No.1

기울기에 따른 경사로의 표면길이의 변화에 대한 사용자 선호도 분석

양소연(Yang, So-Yeon),이태경(Lee, Tae-Kyung) 한국주거학회 2016 한국주거학회 학술대회논문집 Vol.2016 No.4