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임성원 ( Sung Won Lim ),이항락 ( Hang Lak Lee ),이강녕 ( Kang Nyeong Lee ),전대원 ( Dae Won Jun ),김인영 ( In Young Kim ),김은진 ( Eunjin Kim ),안혜인 ( Hyein Ahn ),박찬금 ( Chan Kum Park ) 대한소화기학회 2016 대한소화기학회지 Vol.68 No.3
Myeloid sarcoma (MS) is an extramedullary involvement of immature myeloid proliferation. An isolated MS is defined as a myeloblastic tumor when it arises without any concomitant circulating disease. A diagnosis of MS is established using pathologic features including infiltration of myeloblasts and strong myeloperoxidase expression with negative cytokeratin immunohistochemical staining. We report a rare case of colonic MS without any peripheral blood abnormality. If the affected patient were left untreated, the MS could evolve into acute myeloid leukemia (AML) within one year. Several studies recommend the same regimens of chemotherapy as used for circulating AML to treat isolated MS. We focused on the diagnosis of MS in this study. The correct diagnosis of MS is important for adequate treatment. In conclusion, MS should be considered in the differential diagnosis of intestinal tumor. (Korean J Gastroenterol 2016;68:148-151)