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Advances in serological diagnosis of Taenia solium neurocysticercosis in Korea
안춘섭,김정근,허선,강인석,공윤 한국유전체학회 2019 Genomics & informatics Vol.17 No.1
Cysticercosis, a parasitic disease caused by Taenia solium metacestode (TsM), has a major global public health impact in terms of disability-adjusted life years. The parasite preferentially infects subcutaneous tissue, but may invade the central nervous system, resulting in neurocysticercosis (NC). NC is an important neglected tropical disease and an emerging disease in industrialized countries due to immigration from endemic areas. The prevalence of taeniasis in Korea declined from 0.3%–12.7% during the 1970s to below 0.02% since the 2000s. A survey conducted from 1993 to 2006 revealed that the percentage of tested samples with high levels of specific anti-TsM antibody declined from 8.3% to 2.2%, suggesting the continuing occurrence of NC in Korea. Modern imaging modalities have substantially improved the diagnostic accuracy of NC, and recent advances in the molecular biochemical characterization of the TsM cyst fluid proteome also significantly strengthened NC serodiagnosis. Two glycoproteins of 150 and 120 kDa that induce strong antibody responses against sera from patients with active-stage NC have been elucidated. The 150 kDa protein showed hydrophobic-ligand binding activities and might be critically involved in the acquisition of host-derived lipid molecules. Fasciclin and endophilin B1, both of which play roles in the homeostatic functions of TsM, showed fairly high antibody responses against calcified NC cases. NC is now controllable and manageable. Further studies should focus on controlling late-onset intractable seizures and serological diagnosis of NC patients infected with few worms. This article briefly overviews diagnostic approaches and discusses current issues relating to NC serodiagnosis.
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The Observation of PlcA Mutation and Localization in Aspergillus nidulans
안춘섭,오영택,김정근,한갑훈,이창원,김재원 한국미생물학회 2014 The journal of microbiology Vol.52 No.7
To know the function of the plcA gene, which encodes aputative phosphoinositide-specific phospholipase C, in amodel filamentous fungus Aspergillus nidulans, it was disruptedthorough homologous recombination and examined. The germination rate of ΔplcA was reduced by approximately65% and germination of ΔplcA at a lower temperature(25°C) was much slower than germination under normalconditions (37°C), suggesting the plcA is responsible forcold-sensitivity. The hyphal growth of ΔplcA was slightlyreduced at 37°C and conspicuously reduced at 25°C.Whilegerminating ΔplcA formed giant swollen spores, and generatedshort and thick hyphae. The results of the nuclearexamination of ΔplcA showed nuclear division with missegregation,and the rate of nuclear division was lower thanthat of wild type at both 25°C and 37°C. The results of thisstudy showed that plcA is localized to the nucleus throughintracellular calcium signaling in A. nidulans. The abnormalnuclear division, resulting from plcA gene deletion, affectsconidiation in asexual development. Taken together, theseresults suggested that plcA is required for normal vegetativegrowth, morphogenesis, conidiation, and nuclear divisionin A. nidulans.
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오영택,안춘섭,이경진,김정근,노현수,김재원,이창원 한국미생물학회 2012 The journal of microbiology Vol.50 No.4
Three isotypes of phosphoinositide-specific phospholipase C designated CcPLC1, CcPLC2, and CcPLC3 were identified in Coprinopsis cinerea, through a search of the genome sequence database. The functional role of the PI-PLCs were studied by using U73122, which specifically inhibits the activity of PI-PLC. The specificity of the inhibitor effect was confirmed by using an inactive structural analog U73433. The inhibition of PI-PLCs activity resulted in severely retarded germination of basidiospores and oidia, reduced hyphal growth, knobbly hyphal tips with many irregular side branches, and aberrant (branch-like structure) clamp cells. Furthermore, U73122 definitely inhibited cell wall formation. Here we report that PI-PLCs play important roles in various aspects of C. cinerea biology.
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김정근,안춘섭,손운목,Yukifumi Nawa,공윤 대한의학회 2018 Journal of Korean medical science Vol.33 No.44
Background: Sparganosis is a larval cestodiasis caused by the plerocercoid of Spirometra spp. Since the first description of human sparganosis in 1924, several hundred cases have been reported in Korea. However, systematic approaches for literature surveys of Korean sparganosis have seldom appeared. Methods: We searched publicly available databases such as PubMed, Research Information Sharing Service, and Korea Medical Citation Index with relevant Medical Subject Headings. Results: At least 438 Korean sparganosis cases have been described from 1924 to 2015. Preoperative diagnosis has been significantly increased since the 1980s due to popularization of serological and imaging diagnostics. Cases were largely detected from fifth decades in general, but cerebral sparganosis was detected in relatively young age groups (third and fourth decades). Sparganosis was prevalent in men (75.9%). Consumption of frog/snake and drinking unfiltered water were found in 63.4% and 16.9% of patients, respectively. Most frequently affected sites were subcutaneous tissues (49.9%), followed by the central nervous system (36.2%). Involvements of visceral organs (7.6%), ocular regions (3.6%), and muscles (2.7%) were noticed. In women, breast sparganosis constituted a large proportion (34.2%). Sparganosis associated with immunocompromised patients has recently been reported. Conclusion: Sparganosis has been continuously reported in Korea during the past 90 years, although its incidence has decreased during the last 20 years. The disease is mostly characterized by subcutaneous nodule, but infection of the worm in vital organs often results in serious illness. Continuous awareness is warranted to monitor sparganosis occurrence and associated clinical consequences.
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