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안지윤,권지원,이상목,위원량,이진학,한영근,Jee Yun Ahn,Ji Won Kwon,Sang Mok Lee,Won Ryang Wee,Jin Hak Lee,Young Keun Han 대한안과학회 2008 대한안과학회지 Vol.49 No.9
Purpose: To compare intraoperative and postoperative flap complication rate between the Hansatome Excellus and Zyoptix XP microkeratomes for LASIK surgery. Methods: The intra- and post-operative flap complication rate, in 323 eyes of 167 patients operated on using the Hansatome microkeratome were compared with 260 eyes of 132 patients that were operated on using the Zyoptix XP microkeratome. Results: The Hansatome group showed an intraoperative complication incidence of 2.7% compared to 0.4% for the Zyoptix XP group (p<0.05), but the incidence of postoperative complication was 2.7% in the Zyoptix XP group compared to 0.6% in the Hansatome group (p>0.05). There was no incidence of visually significant complications in either group. Conclusions: The Zyoptix XP showed a significantly decreased intraoperative flap complication rate compared to the Hansatome Excellus microkeratome. The preoperative K value is an important factor for safe LASIK. J Korean Ophthalmol Soc 2008;49(9):1425-1430
안지윤,손유동,권혁술,안희철,Ahn, Ji-Yun,Sohn, You-Dong,Kwon, Hyuk-Sool,Ahn, Hee-Chol 대한임상독성학회 2008 대한임상독성학회지 Vol.6 No.2
A 47-year-old woman ingested about 12 mg of colchicine with suicidal intent. Colchicine, a highly poisonous alkaloid, is a commonly used treatment for gout, Bechet's disease, and familial Mediterranean fever. Despite the knowledge of its side effects, the risk of a significant overdose is under-appreciated. She suffered from acute multisystem toxicity, including gastrointestinal disorders, bone marrow suppression, alopecia, and probable pancreatitis, but she ultimately recovered with supportive therapy. We report a case of acute colchicine toxicity from a single overdose with a review of the literature.
노화에 있어서의 영양소 감지 TOR 경로(Nutrient-Sensing TOR Pathway)의 역할
안지윤,Ahn, Ji-Yun 한국식품연구원 2010 食品技術 Vol.23 No.3
TOR(target of rapamycin)은 모든 진행세포에서 성장과 대사를 조절하는 영양소 인식 단백질 인산화효소(nutrient-sensing protein kinase)로 곤충, 효모, 마우스를 이용한 실험 결과 TOR 신호 전달계는 노화를 조절하는 것으로 밝혀졌다. 또한 TOR은 식이제한 시 나타나는 다양한 보호 효과(생명 연장, 노화 관련 질환 발병 억제 등)의 강력한 중계자로 알려졌다. 본 리뷰에서는 TOR 신호 전달계가 어떻게 노화를 지연시키는가에 대해 다루고자 한다. 노화조절인자로서의 TOR 신호전달계 조절 기전 구명은 매우 중요한 연구 분야이며 노화 관련 질환을 타겟으로 한 제약 및 건강기능식품의 개발을 통해 인간 수명 연장의 꿈을 성취하는 것을 조금 더 앞당길 수 있을 것으로 사료된다.
대하증(帶下症)과 하복부온도 및 기타 동반 증상과의 연관성에 대한 후향적 단면연구
안지윤 ( Ji Yoon Ahn ),최석영 ( Seok Young Choi ),황덕상 ( Deok Sang Hwang ),이진무 ( Jin Moo Lee ),장준복 ( Jun Bock Jang ),이경섭 ( Kyung Sub Lee ),이창훈 ( Chang Hoon Lee ) 대한한방부인과학회 2013 大韓韓方婦人科學會誌 Vol.26 No.3
Objectives: This study aims to research character of the patients with leukorrhea including Digital Infrared Thermal Imaging (DITI) and symptoms associated with leukorrhea in view of Korean medicine theory. Methods: We studied 71 patients visiting ○○ Korean Hospital from April, 2012 to March, 2013. The subjects were categorized in two groups, leukorrhea group (n=40) and control group (n=31). We investigated the difference of DITI and other physical symptoms between two groups. Results: The average temperature of CV4 in leukorrhea group (29.56±0.80℃) were significantly lower than that of control group (30.12±0.54℃)(p<0.01). And there is no statistical difference of temperature of CV17 located in chest area between two groups. But temperature difference between CV17 and CV4 (ΔT) in leukorrhea group (1.18±0.55℃) is significantly higher than control group (0.68±0.43℃) (p<0.01). There is no correlation between leukorrhea and some sypmtoms, like menorrhea, irregular menstruation, fatigue, constipation and loss of appetite. But leukorrhea group is more likely to suffer from dyspepsia and insomnia than control group. Conclusions: Leukorrhea group is related to lower temperature in lower abdomen than control group. And patients with leukorrhea are more likely to appear dyspepsia and insomnia than no leukorrhea group.
유방 섬유선종이 있는 2, 30대 여성의 HRV 특성 연구
안지윤 ( Ji Yoon Ahn ),최석영 ( Seok Young Choi ),이미주 ( Mi Joo Lee ),이진무 ( Jin Moo Lee ),장준복 ( Jun Bock Jang ),이경섭 ( Kyung Sub Lee ),이창훈 ( Chang Hoon Lee ) 대한한방부인과학회 2012 大韓韓方婦人科學會誌 Vol.25 No.4
Purpose: This study aims to analyze Heart Rate Variability(HRV) in women with fibroadenoma compared with non-fibroadenoma women. Methods: We studied 82 patients visiting Kang-Nam Kyung-Hee Korean Hospital Medical Examination Center from January, 2010 to November, 2011. The subjects were categorized in two groups, fibroadenoma group(n=16) and non-fibroadenoma group (n=66). We investigated the difference of HRV between two groups. Results: The square root of the mean squared difference of successive NNs (RMSSD) in fibroadenoma group is significantly lower than non-fibroadenoma group. LF/HF ratio in fibroadenoma group is significantly higher than non-fibroadenoma group. There was no significant difference in low frequency(LF) and high frequency (HF). However, normalized LF in fibroadenoma group is significantly higher than non-fibroadenoma group. In addition, normalized HF in fibroadenoma group is significantly lower than non-fibroadenoma group. Conclusions: Fibroadenoma group is related to autonomic nerve imbalances that is assumed by psychological problems.
요중 malondialdehyde의 정도와 냉증의 연관성에 대한 후향적 단면연구
안지윤 ( Ji Yoon Ahn ),김민영 ( Min Young Kim ),황덕상 ( Deok Sang Hwang ),이진무 ( Jin Moo Lee ),장준복 ( Jun Bock Jang ),이경섭 ( Kyung Sub Lee ),이창훈 ( Chang Hoon Lee ) 대한한방부인과학회 2014 大韓韓方婦人科學會誌 Vol.27 No.3
Objectives: The aim of this study is to identify effects and safety of Koreantraditional medicine, especially including Pinelliae Rhizoma, for hyperemesis gravidarum,and to suggest appropriate dosage and treatment duration of Pinelliae Rhizoma. Methods: The study was performed based on the medical records of 19 hyperemesisgravidarum patients treated with Korean traditional medicine including PinelliaeRhizoma. Change of symptoms, continuance of pregnancy, malformation of infants,and delivery outcomes were analysed. Results: The symptoms of hyperemesis gravidarum were improved in 13 patients. With regards to pregnancy outcome, normal fullterm delivery was 16 case, pretermdelivery was 1 case and abortion was 2 case, Infants malformation was not foundin any case. The average daily dosage of Pinelliae Rhizoma was 6.53 g/day, andthe average treatment duration of Pinelliae Rhizoma was 11.53 (day). Conclusions: In this study, using Korean traditional medicine including PinelliaeRhizoma for hyperemesis gravidarum patients is considered safe if patients aretreated with proper clinical dosage and duration of medication. More cases andstudies in the future will be required for the appropriate use of Pinelliae Rhizomafor hyperemesis gravidarum patients.