안내이물의 임상양상 및 예후인자

심규영,김윤전,김중곤,윤영희,이주용,Kyu Young Shim,Yoon Jeon Kim,MD,June Gone Kim,MD,Young Hee Yoon,MD,Joo Yong Lee,MD 대한안과학회 2013 대한안과학회지 Vol.54 No.3

Purpose: To investigate clinical characteristics of post-traumatic intraocular foreign body (IOFB), which occurred between 2006 and 2010, and prognostic factors associated with final visual outcome. Methods: A retrospective chart review was performed of patients with IOFB who visited our clinic from January 1, 2006 to December 31, 2010, and who were followed up for more than 6 months. Cross tabulation and correlation analyses were conducted to evaluate the predictive factors related to final visual acuity. Results: A total of 36 eyes (35 patients) were included in this study. The mean age was 44.2 years, and 33 patients (94.3%) were male. The most common cause of IOFB was lawnmower-related activity (12 patients; 33.3%) and hammering-related activity (11 patients; 30.1%). Among analyzed prognostic factors, only initial visual acuity was significantly correlated with visual outcomes (p < 0.001). Conclusions: Compared with previous studies, lawnmower and hammering-related activities were still the most common causes of IOFB, however, the incidence of occurrence in the 40’s and 50’s was relatively higher than in previous studies. Considering the poor visual outcome of IOFB even after proper surgical treatment, using proper eye protection should be emphasized in a dangerous work environment to prevent ocular trauma.

현금흐름정보의 효율성에 대한 실증적 연구

심규영 ( Kyu Young Shim ) 韓國生産性學會 2007 生産性論集 Vol.21 No.1

테리엔각막가장자리변성에서 냉동보존된 잔존각막을 이용한 C형 전부층판각막이식술

심규영(Kyu Young Shim),전종화(Jong Hwa Jun) 대한안과학회 2017 대한안과학회지 Vol.58 No.4

목적: 테리엔각막가장자리변성 환자에서 공여각막의 원형절제 후 냉동보존된 잔존각막을 이용한 C형 전부층판각막이식술을 시행한 1예를 보고하고자 한다. 증례요약: 63세 여자 환자는 수년 전부터 발생한 좌안의 이물감과 시력저하를 주소로 본원에 내원하였다. 굴절검사상 +2.25 Dsph=-5.00 Dcyl×111o의 직난시가 있었으며 이에 따른 최대교정시력은 20/20 (스넬렌 시력표)이었다. 세극등현미경검사에서 각막의 상윤부에 인접하여 약 10.0 mm 넓이의 실질 내 지방질 침착이 동반된 반달모양의 각막의 혼탁 및 얇아짐이 관찰되었고, 빛간섭단층촬영에서 혼탁부의 각막이 극도로 얇아져 있음을 확인하였다. 이에 테리엔각막가장자리변성을 진단하였고 외상성 각막파열을 방지하기 위하여 공여각막의 원형절제 후 냉동보존된 잔존각막을 이용한 C형 전부층판각막이식술을 시행하였다. 술 후 18개월까지 경과 관찰하여 세극등현미경검사와 빛간섭단층촬영에서 이식된 각막은 잘 부착되어 있었고, 두께는 잘 유지되었으며 이식거부반응의 발생은 없었다. 결론: 테리엔각막가장자리변성 환자에서 냉동보존된 잔존각막을 이용한 C형 전부층판각막이식술은 얇아진 각막을 수복할 수 있는 효과적인 치료방법이 될 수 있다. Purpose: To report a case of Terrien’s marginal degeneration treated with C-type anterior lamellar keratoplasty using cryopreserved leftover cornea. Case summary: A 63-year-old female visited our clinic because of left ocular discomfort and visual deterioration over several years. The patient had +2.25 Dsph = -5.00 Dcyl × 111° of astigmatism, and best corrected visual acuity was 20/20. Microscopic slit lamp examinations revealed an approximately 10.0 mm width semilunar shaped stromal opacity with surrounding stromal lipid deposit, as well as superficial neovascularization with thinning at superior perilimbal cornea. Anterior segment optical coherence tomography confirmed extreme thinning at the opacified cornea. The patient was diagnosed with Terrien’s marginal degeneration. To prevent corneal perforation, C-type anterior lamellar keratoplasty using cryopreserved leftover cornea was performed. After 18 months after operation, donor graft was successfully attached via the anterior segment optical coherence tomography and microscopic slit lamp examination and graft rejection was not observed. Conclusions: C-type anterior lamellar keratoplasty using a cryopreserved cornea can be an effective therapeutic strategy for Terrien’s marginal degeneration.

약시환아에서 성공적인 가림치료에 미치는 인자와 시력호전기간에 대한 임상분석

심규영(Kyu Young Shim),이동철(Dong Cheol Lee),이세엽(Se Youp Lee) 대한안과학회 2017 대한안과학회지 Vol.58 No.11

적: 굴절부등과 사시에 의한 약시환아 중 가림치료 후 최대교정시력이 1.0으로 호전된 경우를 대상으로 약시 치료기간을 예측할수 있는 인자를 알아보고자 하였다. 대상과 방법: 2세부터 13세까지의 굴절부등과 사시에 의한 약시환아 48명을 대상으로 하였다. 가림치료를 하여 교정시력이 1.0으로 시력호전에 성공한 약시환아에서 약시안의 구면렌즈대응치, 원인(굴절부등, 사시, 혼합), 약시안의 초진 시 교정시력, 가림치료를 시작한 나이 등의 인자들에 따른 치료기간을 비교하였다. 결과: 가림치료 시 초진나이는 평균 5.4세였으며, 시력호전에 걸리는 시간은 평균 22.9개월이었다. 치료기간은 약시안의 구면렌즈대응 치가 +3.0D보다 클 때(p<0.05), 가림치료 시작 시 최대교정시력이 0.2 이하일 때(p<0.05), 가림치료 시작 나이가 만 6세 이상일 경우 (p<0.05) 길어졌고, 약시의 원인에 따른 치료기간은 통계학적으로 유의한 차이는 없었다. 결론: 약시환아를 대상으로 가림치료 시 약시안의 구면렌즈대응치가 +3.0D보다 클 때, 가림치료 시작 시 최대교정시력이 0.2 이하일 때, 나이가 6세 이상일 경우에 시력의 발달 및 회복기간이 길기 때문에, 이 요소들은 약시 치료기간을 예측하는 인자로 고려할 수 있겠다. Purpose: To evaluate the factors affecting successful occlusion treatment and visual recovery time in patients with amblyopia when best corrected visual acuity (BCVA) improved up to 1.0 after occlusion. Methods: Forty-eight patients aged 2 to 13 years old with amblyopia due to refractive errors or strabismus were selected. The duration of treatment needed to achieve a BCVA of 1.0 was compared according to the cause of amblyopia (anisometropia, strabismus, combined), initial BCVA of the amblyopic eye, and the age at treatment, as well as other factors. Results: The mean age of amblyopic treatment was 5.4 years old and the mean duration of treatment was 22.9 months. The duration of treatment was longer in children whose initial BCVA was lower than 0.2, those with spherical equivalent of the amblyopic eye higher than +3.0D and those older than 6 years old. However, there were no significant differences according to the cause of amblyopia. Conclusions: The duration of treatment needed to achieve a BCVA of 1.0 was prolonged when the initial BCVA in the amblyopic eye was lower than 0.2, the age at treatment was more than 6 years old, or the spherical equivalent of the amblyopic eye was higher than +3.0D at treatment. These factors can be used to predict the duration of occlusion treatment. J Korean Ophthalmol Soc 2017;58(11):1254-1259

담수 어류 총수은 분석용 생물 표준물질 균질성, 안정성 시험평가

이수용 ( Soo Yong Lee ),이장호 ( Jangho Lee ),정다위 ( David Chung ),심규영 ( Kyu-young Shim ),이하은 ( Ha-eun Lee ),박기완 ( Ki-wan Park ) 한국환경과학회 2019 한국환경과학회지 Vol.28 No.11

The National Environmental Specimen Bank (NESB) has set up a plan to develop reference materials in the facility for assuring analytical quality and validating analytical methods for its monitoring samples. Some of the crucial characteristics that reference materials must consist of are homogeneity and stability of both intra and inter-bottles. In this study, we examined the homogeneity and stability of cryogenically-milled muscle samples, from Common Carp (Cyprinus carpio) for total mercury. Homogeneity was tested using ANOVA analysis and regression analysis was used to test short-term stability. The variations of total mercury concentration did not significantly differ between the intra and the inter-bottle (F=0.8, p=0.37). Additionally, relative standard deviation of the total mercury concentration showed low values (2.28%). For the short-term stability test, total mercury variations were not statistically significant as demonstrated by the result of the regression analysis (F ratio = 3.11, p = 0.18). This suggests that the cryogenic-milling process has statistically proven the degree of homogeneity and short-term stability for samples of carp muscles in the chemical analysis for total mercury.

강우에 의한 토양호흡 배출 특성이 연간 토양호흡 배출량에 미치는 영향 연구

공학양(Kong, Hak Yang),박성애(Park, Sung Ae),심규영(Shim, Kyu Young),김태규(Kim, Tae Kyu),이재석(Lee, Jae Seok),서상욱(Suh, Sang Uk) 한국기후변화학회 2016 한국기후변화학회지 Vol.7 No.4

강우 이벤트가 태화산 잣나무 식재림의 각 발생원별 CO2 발생량에 미치는 영향

서상욱 ( Sang Uk Suh ),박성애 ( Sung Ae Park ),심규영 ( Kyu Young Shim ),양병국 ( Byeong Gug Yang ),최은정 ( Eun Jung Choi ),이재석 ( Jae Seok Lee ),김태규 ( Tae Kyu Kim ) 한국환경생물학회 2014 환경생물 : 환경생물학회지 Vol.32 No.4

This study was conducted to find out the soil CO2 emission characteristic due to rain fall pattern and intensity changes. Using Automatic Opening and Closing Chambers (AOCCs), we have measured annual soil respiration changes in Pinus koraiensis plantation at Seoul NationalUniversity experimental forest in Mt. Taehwa. In addition, we have monitored heterotrophic respiration at trenching sites (4×6 m). Based on the one year data of soil respiration and heterotrophicrespiration, we observed that 24% of soil respiration was derived from root respiration. During the rainy season (end of July to September), soil respiration at trenching site and trenching with rainfall interception site were measure during portable soil respiration analyzer (GMP343, Vaisala, Helsinki, Finland). Surprisingly, even after days of continuous heavy rain, soil water content did not exceed 20%. Based on this observation, we suggest that the maximum water holdingcapacity is about 20%, and relatively lower soil water contents during the dry season affect the vital degree of trees and soil microbe. As for soil respiration under different rain intensity, it was increased about 14.4% under 10 mm precipitation. But the high-intensity rain condition, such as more than 10 mm precipitation, caused the decrease of soil respiration up to 25.5%. Taken together, this study suggests that the pattern of soil respiration can be regulated by not only soil temperature but also due to the rain fall intensity.

환경오염 지표종인 집비둘기의 생체조직 내 중금속 분포 특성

이장호 ( Jangho Lee ),이종천 ( Jongchun Lee ),박종혁 ( Jong-hyouk Park ),이유진 ( Eugene Lee ),심규영 ( Kyuyoung Shim ),장희연 ( Heeyeon Jang ),김명진 ( Myungjin Kim ) 한국환경영향평가학회 2016 환경영향평가 Vol.25 No.6

본 연구에서는 환경오염 모니터링 지표종인 집비둘기(Columba livia)의 생체조직 내 중금속 축적 특성을 파악하기 위해 국가환경시료은행 자체 모니터링 지점(한강공원, 함평공원)에서 채집된 집비둘기 시료를 분석하고, 집비둘기를 포함한 국내외 조류 총 17종의 연구 자료를 검토하여 생체조직 내 중금속 분포특성을 고찰하였다. 유해 중금속인 카드뮴은 한강공원과 함평공원 모두에서 신장에 가장 높은 축적농도 비율을 보였고, 국내외 집비둘기 사례와 기타 사례 총 34개 중 31개에서도 조류종과 상관없이 거의 대부분 신장이 가장 높은 축적농도 비율을 나타냈다. 유해 중금속인 납은 한강공원과 함평공원 모두에서 뼈가 가장 높은 축적농도 비율을 나타냈으며, 기존 연구사례 총 30개 중 17개에서 뼈에 가장 높은 축적농도 비율을 보였고, 다음으로 신장(10개 사례), 간(3개 사례) 순으로 나타났다. 따라서 납의 주요 축적 조직은 뼈라고 볼 수 있다. 아연은 한강공원에서 간에 가장 높은 축적농도 비율을 보였고, 함평공원에서는 뼈에 가장 높은 비율을 보였다. 기존 연구사례 총 16개 중 13개에서는 뼈에 가장 높은 축적농도 비율을 보였고, 다음으로 간이 차지하였다. 본 연구에서는 이상의 결과 등을 중금속의 생화학적 축적특성(뼈 생성과정에서 납-칼슘의 경쟁관계, 중금속 흡착 단백질(메탈로치오네인)의 역할 등)과 관련하여 검토하였다. 이러한 검토결과는 향후 집비둘기의 오염물질 축적 모니터링 연구의 기초자료로 활용될 수 있을 것으로 기대된다. In this study, heavy metal distributions in the tissues of feral pigeon (Columba livia) were characterized using samples collected from bio-monitoring sites (Hangang Park and Hampyeong Park) of the NESB (National Environmental Specimen Bank), Korea, in order to evaluate the feasibility of feral pigeons as an indicator for the environmental monitoring. Cadmium (Cd) was analyzed to be accumulated in kidneys at higher concentration than in the other tissues. Such trend can also be found in the reviews on the Cd accumulations of the 34 cases including 17 avian species which showed that 31 cases had the highest Cd concentrations in the kidney among tissues. However, lead (Pb) was found to be richest in the bones in this study. 17 cases out of 30 reviewed cases had the highest Pb concentration in bones, whereas other 10 cases showed the highest concentration in kidneys, and 3 cases in livers. Therefore, kidneys together with bones can be a main target organ to test cadmium exposure to different habitat environments depending on physiological traits of birds. Zinc (Zn) was found to be the highest concentration in the pigeon livers of Hangang Park, but not in the bones. In contrast, the 13 cases of 16 reviewed cases had the highest Zn concentration in bones, and the 3 cases in livers. In addition, the heavy metal distribution patterns in relations to the metal accumulation mechanisms (a competition between Pb and Ca, a function of methallothionein protein, and etc.) were discussed.

국가환경시료은행 활엽 시료를 활용한 지역별 대기침적 오염물질 모니터링 활용성 검토

이종천 ( Jongchun Lee ),이장호 ( Jangho Lee ),박종혁 ( Jong-hyouk Park ),이유진 ( Eugene Lee ),심규영 ( Kyuyoung Shim ),장희연 ( Heeyon Jang ) 한국환경영향평가학회 2016 환경영향평가 Vol.25 No.6

국가환경시료은행(NESB)에서는 환경오염물질의 생태계 영향을 모니터링하기 위한 시료로서 8종의 생물시료를 정기적으로 채취하여 초저온(<-130 °C) 저장을 해 오고 있다. 이 중 2 종의 활엽수(느티나무 및 신갈나무 잎)가 중금속 및 잔류성유기오염물질(POPs)과 같은 대기오염물질 모니터링을 위한 환경 시료로서 활용되기 위해 채취되고 있다. 한 지역을 대표하기 위해 군락 내 여러 개체에서 시료를 채취하는 과정에서 개체별 차이 및 오염분포 특성에 따른 이질성이 구성 시료의 대표성에 영향을 미치게 되고 따라서 분석을 통한 측정값을 활용한 연구의 신뢰도에 문제를 초래할 수 있다. 따라서 이러한 시료종은 엄격한 표준운영절차(SOP)에 따라 채취됨으로써 대표성을 확보할 수 있고 이를 근거로 오염물질의 지역간, 연도별 비교가 가능하게 된다. 본 연구에서는 표준운영절차(SOP)에 따라 5 지역의 고정구에서 채취된 신갈나무, 느티나무 잎 시료를 대상으로 지역 간 오염물질의 농도차이를 비교하기 위해 주요원소 및 중금속, 그리고 다환방향족탄화수소(Polycyclic aromatic hydrocarbons, PAHs)에 대한 분석을 실시하였다. 그 결과인 측정값을 활용하기에 앞서 이에 대한 신뢰도 수준을 평가하기 위한 방편으로 시료채취단계에서 중복 시료를, 시료분석단계에서 중복분석을 수행하여 분산분석(ANOVA)을 수행하였다. 이로써 시료채취 및 분석의 단계별 불확도를 분리하여 산출한 후 측정불확도로 통합한 결과 측정값의 지역 간 연도별 농도 비교에 통계적 신뢰도 수준으로 활용할 수 있었다. 아울러 잎표면 대기침적물질 중 강우에 영향을 받는 중금속 및 PAHs 종류를 파악하기 위해 누적강우량과 오염물질의 축적도간 관계를 분석하였다. The National Environmental Specimen Bank (NESB) has been collecting broad leave samples to monitor environmental pollution from five different designated sampling areas. In order to ensure the reproducibility and comparability of the results, all the procedures from selecting trees and pooling leaves to make the representative sample are defined in the standard operation procedures(the SOP). The representative samples were subjected to the chemical analyses for some heavy minerals and Polycyclic Aromatic Hydrocarbons(PAHs). The uncertainty levels involved in each step of the SOP, that is, the sampling and the chemical analysis, were derived using the Robust ANOVA, which enables the relative comparison among the different levels of pollutants concentrations with confidence. Furthermore, the effect of the varying degrees of precipitation on the pollutants concentration of the leaves was also examined. Overall, the biological difference estimated from the duplicate samples was found to exceed the variation across the site, implying even aerial deposition over site. Samples from Gwanak Mt. showed highest heavy metal concentrations than the other sites. Washing off effect of the pollutants adhering in the form of particles on the leaf surface was found to be affected by the cumulative precipitation.

카드뮴 분석용 홍합(Mytilus coruscus) 표준물질의 균질성 및 안정성 시험평가

이하은 ( Ha-eun Lee ),이장호 ( Jangho Lee ),정다위 ( David Chung ),이수용 ( Soo Yong Lee ),박기완 ( Ki-wan Park ),심규영 ( Kyu-young Shim ) 한국환경과학회 2019 한국환경과학회지 Vol.28 No.11

In this study, the KS A ISO Guide 35 was applied to develop analytical standards for heavy metal cadmium using the Korean mussel (Mytilus coruscus) and to evaluate the homogeneity and stability of the sample. Some of the crucial characteristics that reference materials must consist include homogeneity and stability of both intra- and inter-bottles. We tested homogeneity using ANOVA analysis and short-term stability using regression analysis. The variations of cadmium concentrations did not significantly differ between intra- and inter-bottles (F=0.41, p=0.90). For short-term stability verification, cadmium analysis results were not statistically significant as a result of the regression analysis (significance F=0.51, p=0.53). This suggests that we can not dismiss the null hypothesis that there is no significant variation in concentrations of cadmium over time. These results indicated that the cryogenic-milling process has statistically proven the short-term stability for materials from mussels in the chemical analysis of cadmium. Therefore, we propose that the Korean mussel’s reference material developed for the proficiency test could be used as a tool to evaluate reliability and consistency in laboratories.