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신지애,조성대,Eun-Sun Choi,정지윤,조남표 한국식품위생안전성학회 2011 한국식품위생안전성학회지 Vol.26 No.2
Betulinic acid (BA), a naturally occurring triterpene found in the bark of the white birch tree, has been investigated to induce apoptosis in various cancer cells and animal models. However, there is no report of the chemopreventive effect of BA in cervical cancer cells. Using KB human cervical cancer cells as a model, we currently show that BA decreases cell viability and induces apoptotic cell death. The mechanism of the BA-induced anti-growth response in KB cells is due to the down-regulation of specificity protein 1 (Sp1) and its downstream targets, myeloid cell leukemia-1(Mcl-1) and survivin. Thus, BA acts as a novel chemopreventive agent through the regulation of Sp1that is highly expressed in tumors.
장분실,오세준,신지애,조남표,조성대 대한구강악안면병리학회 2014 대한구강악안면병리학회지 Vol.38 No.5
Background. Vitamin K (VK) is a fat-soluble vitamin and is known to have anticancer activity in various cancer cell lines. However, there is no report on the anticancer effect of VK2 in mucoepidermoid carcinoma cells. Methods. The effects of VK2 on anti-proliferative and apoptotic activity were recognized by the trypan blue exclusion assay, 4'-6-diamidino-2-phenylindole (DAPI) staining and Western blot analysis. Results. The results showed that VK2 decreased cell viability and induced apoptotic programmed cell death in MC3 cells evidenced by the cleavages of caspase3 and PARP. VK2 treatment clearly increased Bak and truncated Bid (t-Bid) compared with the control treatment whereas it did not alter other Bcl-2 family members. Conclusions. Overall, our results suggest that VK2 can be a good apoptotic inducer accompanied by the increase in Bak and Bid protein. VK2 may be a potent target of anticancer drug candidate for the treatment of oral cancer.
사람 두경부세포암종에서 세포질 내 HuR 발현 및 미세혈관 밀도와 제 2형 사이클로옥시기나제 과발현과의 상관관계
한혜숙,조성대,심정현,신지애,조남표 대한구강악안면병리학회 2009 대한구강악안면병리학회지 Vol.33 No.6
The human embryonic-lethal abnormal vision-like protein, HuR, stabilizes mRNA containing adenine- and uridine- rich elements in their 3’untranslated region. Because cyclooxygenase-2 (COX-2) mRNA is a cellular transcript that contains an adenine- and uridine-rich element, it can be regulated by the HuR protein. In this study, we examined the relationship between COX-2, HuR, MVD, and the clinicopathological parameters. Nineteen out of 43 cases of HNSCC showed high level of COX-2expression, and 68% of these patients showed high COX-2 immuno-reactivity indicating the strong expression of the cytoplasmic HuR protein. Also, MVD expression in the cases with high COX-2 expression was higher than in the cases with low COX-2 expression. These results suggest a strong correlation between the overexpression of cytoplasmic HuR and COX-2 expression in HNSCC, and that COX-2 is associated with MVD in HNSCC. In conclusion, COX-2 regulated by cytoplasmic HuR may be a good tumor angiogenic factor in HNSCC.
나종열,신지애,최기선 한국정보과학회 언어공학연구회 2007 한국정보과학회 언어공학연구회 학술발표 논문집 Vol.2007 No.10
본 연구에서는 문서의 문장들을 순위화하여 추출하는 일반적인 문서 요약 방법론을 소개한다. 첫 번째 단계는 주제와 관련되는 동사, 명사, 형용사(VNA) 단어들의 집합을 구하여 각 문장의 주제 관련성 정도를 결정하며, 두 번째 단계는 단어들의 의존관계를 통해 각 문장의 정보 함유량을 판단한다. 두 개의 방법은 모두 주제와 관련된 정보를 많이 내포하는 문장에 중요도를 부여하고 있다. 이러한 방법은 주제와 연관성이 높고 정보전달성이 높은 문서요약을 만들기 위함이다. 생성된 문서요약본의 성능평가는 문서요약의 결과로 추출된 문장들과 설문에 의해 추출된 문장들의 일치율에 의해 시행되었으며 68%의 일치율을 보였다.