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- 저자 : 신재규(Jae Kue Shin) (검색결과 2 건)
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성상신경절 차단이 혈장 ACTH 및 Cortisol 치에 미치는 영향
채영근(Young Geun Choi),송장호(Jang Ho Song),임현경(Hyun Kyung Lim),한정욱(Jung Wook Han),이성근(Seong Keun Lee),차영덕(Young Deog Cha),신재규(Jae Kue Shin),류중하(Jung Ha Ryu) 대한통증학회 2002 The Korean Journal of Pain Vol.15 No.1
N/A Background: Stellate ganglion block (SGB) is a sympathetic nerve block method which has been used most frequently in pain clinics due to its wide range of indications. This study was conducted to determine the endocrinologic response to repeated SGBs. Methods: Thirteen healthy volunteers were studied. SGB was performed one hunderd times with 6 ml of 1% mepivacaine. Venous blood was drawn to measure plasma adrenocorticotrophic hormone (ACTH) and cortisol consentration before and after SGB for twenty, forty, sixty, eighty and one hundred times. The blood was drawn at 8:00 a.m. and 4:00 p.m. every sampling day. Results: The plasma concentration of eortisol at 8:00 a.m. was significantly higher after SGB one hundred times than prior to SGB. The plsma concentration at 4:00 p.m. was significantly higher after SGB forty times than prior to SGB. The ACTH concentration was significantly times at 4:00 p.m. Conclusions: After SGB, the plasma concentration of cortisol tended to increase while the ACTH levels tended to decrease. However, the effects of endocrinologic response to SGB were unclear since all values were within the normal limit.
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백서에서 좌골신경 절단 및 Phenol 국소침윤이 척수의 c-fos 발현에 미치는 영향
김태정,임현경,박동호,차영덕,정종권,한정욱,승익상,신재규 대한마취과학회 2000 Korean Journal of Anesthesiology Vol.38 No.5
Background : Phenol has effects like surgical neurectomy, but may evoke pain after local infiltration in nerves. Transection of peripheral nerves may induce neuropathic pain through increased spontaneous discharge and other mechanisms. Proto-oncogene, c-fos, is an indicator of neuronal activity, and its expression in the spinal cord may be related to pain development, because inhibition of c-fos expression has corresponding effects like analgesia. We evaluated the effects of local infiltration of phenol and transection iojury at the sciatic nerve on c-fos expression in the spinal cords of rats. Methods : Sixteen male Sprague-Dawley rats were divided into 2 groups; transection of the sciatic nerve was performed for group 1; phenol was infiltrated into the sciatic nerve in group 2. Three hours, 1 week, 2 weeks, and 3 weeks after the experiment, the corresponding spinal cord was stained immuno- histochemically for c-fos. Results : c-fos was expressed from 3 hours to 2 weeks over the laminae of the dorsal horn in each group. Phenol increased the expression of c-fos initially, but decreased 1 week later. Transection injury did not increase it initially, but showed the peak expression at 1 week, and maintained it for 2 weeks. Therefore, it seems that phenol, rather than the transection injury, stimulates c-fos expression early, but decreases later. Conclusions : Phenol treatment, caused by chemical block due to protein denaturation and nonspecific inflammation, may induce less neuropathic pain than the transection of a nerve. (Korean J Anesthesiol 2000; 38: 894~903)
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