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신연교,이용진,안재억,우극현,김주자,이병국,Shin, Yeon-Gyo,Lee, Yong-Jin,Ahn, Jae-Eog,Woo, Kuck-Hveun,Kim, Joo-Ja,Lee, Byung-Kook 대한예방의학회 1995 Journal of Preventive Medicine and Public Health Vol.28 No.3
This is to analyze and compare the distribution of the liver function test and its abnormal rates of the preemployment screening for office workers in asymptomatic young age groups between female and male. Liver function test(SGPT and SGOT) of 8,184 young adults(2,633 in female and 5,551 in male ) were examined during the period from Jan.1, 1994 to Dec.31, 1994. The results were as follows; 1. Mean level of SGPT was $9.1{\pm}7.6(IU/L)$ in female, $21.0{\pm}27.9(IU/L)$ in male, and that of SGOT was $15.1{\pm}6.0(IU/L)$ in female, $20.5{\pm}26.5(IU/L)$ in male. There were significant differences(p<0.01) between female and male in both SGPT and 5G07 And also there was significant increasing trend(p<0.05) by age groups in male for SGPT, decreasing trend(p<0.01) in female for SGOT, 2. In the abnormal rates of liver function test by the level of cut-off value, there were significant differences up to twice between the lowest and the highest cut-off value in both female(0.4% vs 0.7%) and male(6.5% vs 32.4%) 3. Abnormal rate of SGPT was 0.4% in female and 6.3% in male, and that of SGOT was 0.2% in female and 1.2% in male with significant differences between female and male in both tests. 일개 대학병원에서 1994년 1월 1일부터 12월 31일까지의 기간 동안 사무직입사를 위하여 건강진단을 실시한 $17\sim29$세의 8,184명(여자 2,633명, 남자 5,551명)의 간기능 검사 결과를 분석하여 간기능 검사의 분포와 이상수준을 남녀별로 비교분석하여 무증상 젊은 여자에 있어서 간기능 검사의 유용성을 검토하였다. 1. 연령별, 성별에 따른 간기능 검사의 항목별 평균값은 SGPT의 경우 여자 $9.1{\pm}7.6(IU/L)$, 남자 $21.0{\pm}27.9(IU/L)$ 였으며, SGOT의 경우 여자 $15.1{\pm}6.0(IU/L)$, 남자 $20.5{\pm}26.5(IU/L)$ 각각 남녀간의 유의한 차를 보였으며(p<0.01), 연령에 따른 평균치의 분포는 SGPT는 남자에서만 유의하게 증가하였으며(p<0.05), SGOT는 여자에서만 유의하게 감소하였다(p<0.01). 2. 각 기준치에 따른 간기능 검사의 이상률로는 가장 낮은 검사실 기준치를 정할때 전체 8.6%(705/8,184), 여자 0.7%(19/2,633), 남자 12.4%(686/5,551)로 1:17.7의 비로 유의한 차를 보이고 있었다(p<0.01). 제일 높게 정한 노동부 고시에 의한 관리한계치로 정할 때의 간기능 이상률은 전체 4.6%(372/8,184) 여자 0.4%(11/2,633) 남자 6.5%(361/5,551)로 1:16.3의 비로 유의한 차를 보이고 있었다(p<0.01). 3. 성별에 따른 간기능 검사의 항목별 이상률은 SGPT의 경우 여자 0.4%(l1/2,633), 남자 6.3%(352/5, 551), SGOT의 경우 여자 0.2%(5/2,633), 남자 1.2%(69/5,551)이었으며 남녀간에 모두 유의한 차를 보이고 있었다(p<0.01). 연령증가에 따른 간기능 이상률은 남자 SGPT에서만 유의하게 나타났다(p<0.01). 이상에서 볼 때 $17\sim29$세 연령군의 여자에서의 간기능 이상률은 매우 낮으므로 무증상의 젊은 여성군에 있어서 일률적으로 간기능 검사를 시행하는 것에 대한 재검토가 필요하다고 사료된다.
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내당성장애군에서의 당뇨병 발생률과 그 위험요소에 관한 연구
박주희,신연교,안재억,김주자,남택승,이병국,Park, Joo-Hee,Shin, Yeon-Gyo,An, Jae-Eok,Kim, Joo-Ja,Nam, Taik-Sung,Lee, Byung-Kook 대한예방의학회 1994 Journal of Preventive Medicine and Public Health Vol.27 No.3
This is to study the incidence of Diabetes and its risk factors in the impaired glucose tolerence group. 1084 subjects who had been examined 3 times for regular check-up in one human dock center under the university hospital were studied between $1986{\sim}1993$. The results are as follows; Prevalence rate of diabetes was 3.56%, and that of impaired glucose tolerence was 30.90% as of initial examination. The rate of diabetes was increasing with the age where 1.2% at age group $30{\sim}39$, 3.21% at age group $40{\sim}49$, 5.84% at age group $50{\sim}59$, 14.28% at age group 60 and over. And also the rate of impaired glucose tolerance was increasing with the age where 21.29% at age group $30{\sim}39$, 31.42% at age group $40{\sim}49$, 38.91% at age group $50{\sim}59$, 33.33% at age group 60 and over Of the examinees who were initially examined, total incidence rate of diabetes who developed to obvious diabetes at the 3rd follow-up examination from the initially impaired glucose tolerence group was 4.63% and it was 11.3 times higher than from the normal group (0.41%). After controlling for the effects of both age and obesity, the risk of subsequent diabetes for subjects with impaired glucose tolerance remained significantly higher than for normal subjects (Relative Risk, 10.48). Test for trends for developing to diabetes by the increasing level of fasting blood sugar and 1hr blood sugar at the initial examination were statistically significant in either normal and impaired glucose tolerence group. To determine the risk factor for developing to diabetes, logistic regression test was applied. Only fasting blood sugar and 1hr blood sugar were predictors for developing diabetes from the impaired glucose tolerence group at initial examination.
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20-30대 무증상 성인에 있어서 채용신검시 나타난 간기능 및 바이러스 간염검사 결과 분석
김주자,신연교,우극현 순천향의학연구소 1995 Journal of Soonchunhyang Medical Science Vol.1 No.2
To determine the distribution of results of liver function test and viral markers for preemployment screening in asymptomatic young adults(twenties and thirties in age group), and also to evaluate the cutoff level of liver function test in deciding repeat follow-up examination. the data from which the first and second repeated examinations for preemployment screening performed during the period from Jan, 1, 1994 to Dec. 31 1994 were analized. The results were as follows: 1. Among 7,855 asymptomatic young adults who were examined, 814 (10.4%) had the abnormal liver function test (10.4% (814/7,855) in male, 0.8% (14/1,707) in female. 2. In 397 male who had repeated follow-up test, 27.2%(108/397) were turned out normal liver function test and 72.8%(289/397) remained abnormal. According to the interval of repeated follow-up test, the longer the interval the higher conversion rate to normal. This can be explained by the effect of treatment of health care, or was dropped from 87.5%(7/8) to 44.2%(23/52) at 401U/dl and that of SGOT was dropped from 80.7%(25/31) to 67.9%(19.28) at 451U/dl which suggest cutoff level to decide repeated follow-up test. This suggest that we can adjust the cutoff level in deciding follow-up examination. 3. Overall positive rates for HBsAg were 5.8%(80/1,561), and 5.9%(80/1,347) in age group 20-29, 4.7%(10/214) in age group 30-39, 6.0%(73/1,214) in male, 4.9%(17/347) in female. Positive rate for HBsAg according to the liver function test was significantly higer in abnormal liver function group than in normal liver function grup (12.7% vs 4.8%). 4. Positive rate for anti-HBs was 32.7% and there were no significant difference between age groups or between liver function groups. 5. Positive rate for anti-HCV was 1.3%(5 in 397 male), actually all 5 were in age group 20-29, among them, 3 had normal liver function test and 2 had abnormal liver function test.
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