http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
미시적 교통류 시뮬레이션을 활용한 교통영향평가 분석기법 개선방안
신대섭,이선하,Shin,Dae-Sup,Lee,Seon-Ha 한국방재학회 2008 한국방재학회논문집 Vol.8 No.1
기존의 교통영향평가 지침으로 규정된 사업 시행 전후의 교통흐름은 가로구간의 경우 교통량, V/C, 평균통행속도와 서비스수준, 교차로의 경우 서비스 수준 등의 교통류 분석지표에 의하여 분석되고 있다. 이러한 교통류 분석지표는 확률론적(stochastic)인 교통류의 특성을 효율적으로 번영하지 못하며, 특히 개별 가로구간과 교차로에 국한하여 분석됨으로서 사업 시행으로 인한 교통영향 분석 범위 전체 구간의 교통흐름을 종합적으로 분석하기에는 미흡하다. 본 연구는 차량추종모형(Car-Following Theory)에 의한 미시적 시뮬레이션(microscopic-simulation) 기법을 적용하여, 개별 구간과 교차로 분석 범위를 넘어서 사업 대상 교통영향 반경 내의 교통흐름을 가시적(visual)하게 보여줄 수 있는 방안과 이를 바탕으로 공간적 범위 설정 개선방안, 개선대책 수립에 따른 효과분석 방안 등 다양한 분석결과를 도출하였다. Traffic flow which is prescribed under previous traffic effect/access act is analyzed by traffic volume, V/C, mean speed on road and LOS on the intersection. These indexes based on analytical method can not consider stochastic characteristics of traffic flow. Moreover it is hard to analyze traffic flow visually in whole traffic effect area because only individual road and intersections are targeted. In this study, it is devised to show traffic flow analysis method within traffic effect area visually applying microscopic-simulation by car-following theory, and then based on this, effect analyze ways are studied according to space range plan, improvement measure establishment and etc. To execute this study, effect area is set up using V/C, and the change of traffic current around development area is analyzed using microscopic-simulation program.
MK-801 투여에 의한 몰핀의존성랫드 뇌선조체중 도파민신경전달물질의 변화
이선희(Sun Hee Lee),신대섭(Dae Sup Shin),이덕주(Duck Joo Rhie),유영아(Young A Yoo),류승렬(Seung Rel Ryu),김대병(Dai Byung Kim),이종권(Jong Kwon Lee),김부영(Pu Young Kim) 한국응용약물학회 1998 Biomolecules & Therapeutics(구 응용약물학회지) Vol.6 No.1
The roles of dopamine(DA) and N-methyl-D-aspartate(NMDA) system in the development and expression of morphine dependence were investigated by monitoring the concentrations of extracellular DA and its metabolites by in vivo microdialysis and simultaneous observation of behavioral changes in morphinedependent rats. Extracellular DA level in caudate putamen of morphine-dependent rat was decreased and the concentrations of its metabolites, dihydroxy phenylacetic acid(DOPAC) and homovanillic acid(HVA), were increased during naloxone-precipitated withdrawal. DA contents were recovered to normal levels by pretreatment of MK-801, a noncompetitive NMDA receptor antagonist, which may explain the mechanism of diminishing effect of MK-801 on withdrawal symptoms in morphine-dependent rats. MK-801(0.3 mg/kg, i.p.) induced the untoward harmful neurological signs such as ataxia and severe rotations, which may be produced by hyperactivation of dopaminergic system. These results suggest that MK-801 may inhibit the expression of morphine dependence by altering the dopamine release.
톨루엔 흡인이 뇌내 아미노산 신경전달물질 함량에 미치는 영향
이선희(Sun Hee Lee),신대섭(Dae Sup Shin),김부영(Pu Young Kim) 한국응용약물학회 1995 Biomolecules & Therapeutics(구 응용약물학회지) Vol.3 No.1
The effects of toluene inhalation on the contents of amino acid neurotransmitters in rat brain were investigated and blood toluene concentrations inducing changes of behavior and amino acid neurotransmitter contents in rat brain were observed. Male wistar rats were exposed to toluene vapor (single dose : 1700, 5000 and 10000 ppm for 2 hrs, repeated dose : 1700 and 5000 ppm for 2 hrs/dayx6 days). Toluene concentrations in blood and the inhalation chamber were assayed by GC with headspace sampler. HPLC method foliowing PITC derivatization was used to measure the amino acid contents in brain tissues such as frontal cortex, caudate, hippocampus, cerebellum and brain stem. Glutamic acid and aspartic acid levels were increased by single inhalation of toluene (5000 ppm) in all the brain areas assayed in this experiment. In caudate and cerebellum, taurine levels were decreased by single inhalation of low dose toluene (1700 ppm), but increased by repeated administration. At high blood toluene concentration, GABA levels were increased in all the brain areas assayed in this experiment and the increasing extents of inhibitory amino acid contents measured in caudate and hippocampus were greater than those of excitatory amino acids. These results suggest that the changes of amino acid neurotransmitter contents in brain by exposure to toluene may modulate toluene-induced behaviors.