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정수교,양우진,손형선,신경섭,박용휘 ( Soo Kyo Chung,Woo Jin Yang,Hyung Sun Sohn,Kyung Sub Shinn,Yong Whee Bahk ) 대한핵의학회 1994 핵의학 분자영상 Vol.28 No.3
Pulmonary clearance of Tc99m DTPA(PCD) has been used for the measurement of pul-monary epithelial permeability. It, has been reported to be increased not only in variety of pul-monary diseases including ARDS, interstitial fibrosis, and smokers, but also in normal subject,s on posit.ive end expiratory pre,ssure respirator, or after exereise. It was also noted that decrease of pulmonary blood flow due to pulmonary arterial obstruction results in delayed PCD. Normal range of PCD varies with institutes. We prospectively rneasured PCD in 17 normals (5 males and 12 females) consisted of staffs and trainees in the department of radiology of Kangnam St, Marys hospital using original Bark Nebulizer (India). Age ranged from 32 to 43 years. 370 MBq of Tc99m DTPA was inhaled in supine position and supine posterior images were subsequently obtained with 1 min/frame, 64 x 64 matrix and word mode for 30min. Regions of in 1,erest. Were set on each lung, whole lungs, and upper, middle and lower thirds of right lung, respectively. Best fit regression curve was obtained by least square method from inilial 7min after peak act,ivitu on each curve and time for half clearance of maximum activity (tl/2) was calculat,ed. Mean tl/2 was 51 +- 11.2min for whole lung, There was no significant difference between tl/ 2 of right and left lungs, Initial uptake was higher in the lower third and tl/2 was shorter in the lower third than in the upper third(P<0.05). We reviewed several reports on PCD and compared our data with the others. In t,his study, faster clearance in the lower third may be due to the position imaged with or the environment the subject.s belong to, and further invest,igation is under way.
전이성 척추 악성 종양의 진단 - 골스캔과 자기공명영상의 비교
김기준,손형선,박정미,정수교,이재문,김춘열,박용휘,신경섭 ( Ki Jun Kim,Hyung Sun Sohn,Jeong Mi Park,Soo Kyo Chung,Jae Moon Lee,Choon Yul Kim,Yong Whee Bahk,Kyung Sub Shinn ) 대한핵의학회 1994 핵의학 분자영상 Vol.28 No.3
Authors retrospectively compared the 99mTc MDP bone scans and corresponding MR imagings in 20 patients with histologically proven malignancy. Mean interval of the two studies was 16.6 days. Cancer diagnosis included 8 lung, 2 each of colon, breast, stomach, 1 each of prostate, thyroid, malignant lymphoma and 3 adenocarcinoma of unknown primary site. Of the 105 regions compared, 46 regions were positive for metast,ases in bone scans ar MR imagings. 30 regions(65.2%) were positive by bone scan and 44 regions(95. 7%) by MR imaging. 87 regions(82.9%) were concordantly positive or negative by bone scan and MR imaging, but 18 regions(17.1%) were discordant. In the discordant regions, 16 regions positive in MR imaging were negative in bone scan. The greatest number of discordant findings occurred in the cervica.l region and in the patient with stomach cancer. Our results suggest t.hat the sensitivity of MR imaging is great,er than that, of bone scan in det.ecting spinal metastases. And bone scan is useful screening test of metastasis for evaluting entire skeleton including spine.
201Tl / 99mTc Pertechnetate 감영스캔을 이용한 부갑상선 항진증의 진단
박용휘(Yong Whee Bahk),김춘열(Choon Yul Kim),정수교(Soo Kyo Chung),신경섭(Kyung Sub Shinn),김성훈(Sung Hoon Kim),손형선(Hyung Sun Sohn),안보영(Bo Young Ahn),김의녕(Euy Neyung Kim) 대한핵의학회 1995 핵의학 분자영상 Vol.29 No.4
N/A 201Tl/99mTc pertechnetate subtraction scintigraphy of the parathyroid gland performed in a study of 8 patients with clinical and biochemical evidence of hyperparathyroidism for diagnosis and localization of the lesion prior to sugery. 6 cases of parathyroid adenomas were accurately localized and 2 cases of diffuse hyperplasia associated with chronic renal failure(CRF) and multiple endocrine neoplasia(MEN) type I. 201Tl/99mTc pertechnetate scan was useful for patients with hyperparathyroidism, especially in definite localization preoperatively.
외상후 뇌손상 환자에서 Tc-99m-HMPAO 국소뇌혈류 SPECT 와 자기공명영상의 비교
유원종,이상훈,손형선,이한진,박정미,정수교,김춘열,박용휘,신경섭 ( Won Jong Yoo,Sang Hoon Lee,Hyung Sun Sohn,Han Jin Lee,Jeong Mi Park,Soo Kyo Chung,Choon Yul Kim,Yong Whee Bahk,Kyung Sub Shinn ) 대한핵의학회 1994 핵의학 분자영상 Vol.28 No.3
The purpose of this study was to compare Tc 99m HMPAO SPECT with MRI aft,er acute and subacute closed head injury. There were thirty two focal lesions in all cases of these, Fifteen lesions(47%) were seen on both MRI and SPECT. Fourteen lesions(44%) were seen only on MRI. Three lesions(9%) were seen only on SPECT. Of the 14 lesions seen only on MRl, one was epidural hematoma, two were subdural hematoma, three were subdural hygroma, one was intracerebral hematoma, four were contusion, and three were diffuse axonal injuries. SPECT detected 52% of the focal lesions found on MRI. For the detection of lesions, MRl was superior to SPECT in fourteen cases, while SPKCT was superior to MRI in three cases. In conclusion, there was a tendency that detection rate af the traumat,ic lesions was higher on MRI, but the SPECT could delineate more wide extent, of lesion.
만성 신부전 환자에서 99mTc - HMDP 골신티그램상 섭취정도와 혈중 osteocalcin , 부갑상선 호르몬치와의 상관관계
김춘열(Choon Yul Kim),정수교(Soo Kyo Chung),신경섭(Kyung Sub Shinn),손형선(Hyung Sun Sohn),김의녕(Euy Neyng Kim),방찬영(Chan Young Band),박철휘(Chul Whee Park),장윤식(Yoon Sik Chang) 대한핵의학회 1996 핵의학 분자영상 Vol.30 No.3
N/A In this preliminary study, plasma osteocalcin, PTH level and Tc-99m-HMDP (hydro- xymetylene diphosphonate) bone uptake(BU) were measured in 14 patients with chronic end-stage renal failure who were on maintenance hemodialysis. The aim of this study was to determine the difference of bone uptake between renal failure patients and normal volunteers, and to determine the correlation between bone uptake and osteocalcin a sensitive and specific marker of osteoblastic activity and PTH - a important hormone of bone metabolism. There was a statistically significant increase in 180 minute uptake in the patient group when compared to the normal volunteers while there was no statistically significant difference in 20 minute uptake. Plasma osteocalcin and PTH levels were also significantly elevated compared to normal values. But the correlation between osteocalcin, PTH and 20 and 180 minute bone uptake was not significant. In conclusion, our preliminary study suggests that, in chronic renal failure patients, 180 minute Tc-99m-HMDP bone uptake is increased significantly without direct correlation with serum osteocalcin or PTH levels. It seems that further study is needed to evaluate other unknown factors that may influence the direct correlation between bone uptake and plasma osteocalcin and PTH in patients with chronic renal failure.
99mTc DTPA와 99mTc HMPAO를 이용한 뇌사결정
박석희(Seog Hee Park),박용휘(Yong Whee Bahk),김춘열(Choon Yul Kim),정수교(Soo Kyo Chung),신경섭(Kyung Sub Shinn),이성용(Sung Yong Lee),김성훈(Sung Hoon Kim),양우진(Woo Jin Yang),손형선(Hyung Sun Sohn),김종규(Jong Kyu Kim) 대한핵의학회 1995 핵의학 분자영상 Vol.29 No.1
N/A To evaluate availability of cerebral radionuclide imaging for diagnosis of brain death, we examined 25 patients with a suspected clinical diagnosis of brain death. 8 patients were studied by Tc-99m-DTPA and 15 patients were by Tc-99m-HMPAO (Hexamethyl propyleneamine oxime). Seven patients with Tc-99M-DTPA studies revealed absence of cerebral blood flow and sagittal sinus activity. All of 15 patients with Tc-99m-HMPAO studies revealed complete absence of cerebral perfusion. The results of the cerebral radionuclide studies of brain death correlated with other clinical conditions, such as intracranial pressure(ICP), EEG, transcranial doppler sono- graphy(TCDS), and neurologic examination. The ICP of 8 patients, who are confirmed by brain death with Tc-99m-HMPAO study are elevated in all cases. In conclusion, cerebral radionuclide imaging for diagnosis of brain death is available. Tc-99m-HMPAO imaging is unequivocal, easily interpreted, well reflect the physiologic state of increased ICP, and provides adequate assessment of posterior fossa activity. In addition, the SPECT imaging with Tc-99m-HMPAO produces more accurate results due to it's superiority of image contrast and proper localization of radiopharmaceutical distribution than conventional planar imaging.