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송창화(Chang-Wha Song),이용근(Ryong-Geun Rhee),최형진(Hyung-Jin Choi),양해술(Hae-Sool Yang) 한국정보과학회 1994 한국정보과학회 학술발표논문집 Vol.21 No.2B
일반적으로 사용자는 소프트웨어의 부분적인 기능만을 이용하는 경우가 많다. 다기능 소프트웨어에서 필요한 기능만을 남기고 불필요한 기능을 삭제한 소프트웨어를 구축할 수 있다면, 프로그램 사이즈를 절감시켜 실행 효율을 증대시키고 그 프로그램을 유사 시스템에 재이용할 수 있다. 본 연구에서는 프로그램상의 입출력 값을 제한함으로서 프로그램의 실행 효율을 높일 수 있는 방법을 제안한다.
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Cu(II) 이온이 Nalidixic Acid의 DNA와의 상호작용에 미치는 효과
류형원,오봉경,서정인,송창화,고동성,Ryu, Hyeong-Won,Oh, Bong-Kyeong,Suh, Jeong-Ihn,Song, Chang-Wha,Ko, Thong-Sung 생화학분자생물학회 1991 한국생화학회지 Vol.24 No.4
생리적 pH에서의 흡수차이분광학적 적정 및 형광분광학적 적정 데이터로부터 $Cu^{2+}$는 nalidixic acid와 비교적 안정한 양하전의 평면성 킬레이트복합체(1 : 1)를 형성할 수 있으며 이 복합체는 유리(free) nalidixic acid의 경우와는 달리 DNA와의 직접적인 염기쌍 사이에의 nearest neighbor exclusion 방식의 intercalation 결합을 통한 상호작용을 할 수 있음을 변성 calf thymus DNA에서는 볼 수 없는 ethidium bromide의 그 본성 DNA와의 결합에 대한 이 복합체의 경쟁적 억제효과 특성으로부터 알 수 있었다. 또한 이 $Cu^{2+}$-nalidixate는 유리 nalidixic acid와는 달리 DNA에 intercalative 결합을 하므로써 DNA의 삼차원적 구조의 변형을 초래하여 점성도의 중가를 나타냈으며 변성 DNA에서는 볼 수 없는 이러한 점성도 증가의 특성으로부터 nearest neighbor exclusion intercalation의 가능성을 다시 확인할 수 있었다. Nalidixic acid has been shown to be capable of direct binding with DNA in an intercalative fashion via the formation of relatively stable planar cationic 1:1 chelate complex with Cu(II) at physiological pH as studied by the absorption difference spectroscopic and fluorescence spectroscopic titration data, competitive binding experiments using ethidium bromide, and viscosity increase caused by the three-dimensional structural change of the DNA. The nearest neighbor exclusion type of direct intercalative binding of the Cu(II) complexes with double-stranded DNA between the base-pairs was not exhibited by the denatured DNA.
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Cu ( Ⅱ ) 이온이 Nalidixic Acid 의 DNA 와의 상호작용에 미치는 효과
류형원,오봉경,서정인,송창화,고동성 ( Hyeong Won Ryu,Bong Kyeong Oh,Jeong Ihn Suh,Chang Wha Song,Thong Sung Ko ) 생화학분자생물학회 1991 BMB Reports Vol.24 No.4
Nalidixic acid has been shown to be capable of direct binding with DNA in an intercalative fashion via the formation of relatively stable planar cationic 1:1 chelate complex with Cu(II) at physiological pH as studied by the absorption difference spectroscopic and fluorescence spectroscopic titration data, competitive binding experiments using ethidium bromide, and viscosity increase caused by the three-dimensional structural change of the DNA. The nearest neighbor exclusion type of direct intercalative binding of the Cu(II) complexes with double-stranded DNA between the base-pairs was not exhibited by the denatured DNA.
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韓國영유아 運動行動發達에 關한 硏究 : 特히 영유아의 運動, 探索, 社會, 習慣, 言語등의 各行動 發達과 그의 身體 및 骨發育 및 環境과의 相互關聯性에 對하여
宋昌華 경북대학교 의학연구소 1964 慶北醫大誌 Vol.5 No.1
During the past decade physical and mental development studies of Korean children have been made. In these studies, physical growth including height, weight, head and chest circumference, and the Bone Age, were standardized The author1s present study was undertaken in an attempt to establish the range of normal mental development of physical and motor activity for the Korean form newborn to 3 years of age. 2053 normal children (1139 boys and 914 girls) living in various parts of the country were examined by direct observation and questionary check method which is simple in its procedure and easy to determine. The relationship between physical and osseous development and the mental development was also investigated. A comparison of the developmental quotient (D.Q.) also was made among Korean and Japanese, American, children. The characteristics of child growth and development can aid in understanding normal children both mentally and physically. Intelligent handling of children requires a knowledge of how children grow and how such growth can be favorably influenced. Doctors who do not understand normal children are handicapped in the diagnosis and treatment of abnormal children. Children are particuiarly in need of guidance from doctors, as well as from teachers, child health workers and others outside the home environment. If we know something of the sequence of growth we should be able to provide instruction which would help children to make the best of each phase and prepare better for each ensuing phase. On looking over the literature regarding these studies on oriental children, a few reports were made by japanese authors. However no data or standard is available by which to evaluate the D.Q. for Korean children. Foreigh standard are not applicable to Korean children. Thus it is strongly urged that physicians working in the field of pediatrics and public health develop a new standard applicable to the evaluation of mental status of Korean children. The authors have attempted to establish simple method to evaluate Development of physical and motor activity the standard of mental development of Korean children. We have applied methods which combines both crosssectional and longitudinal studies. These concern the measuring and testing of normal Korean children from birth to three years of age. Between 1961 and 1964, 2053 children (1139 boys, 914 girls) have been examined. In order to evaluate the D.Q., total 268 items of tests were applied to the five areas (motor, behavior, speech, eating habit, social development etc.) according to age, sex, feeding method, geographical, socioeconomic standard. the relationship between physical measurement and mental development, and also skeletal maturation. A comparison of the D.Q. was ,made betweem rural and urban children, breast fed and artificially fed, orphaned children and those raised in the home envioronment. A comparison of D.Q. was also made between Korean and foreign children including Japanese and American. The data and results of the studies are summarized in Fig. I, and 10. In order to evaluate the status of the mental development of Korean children, the developmental patterns were classified (divided) into 5areas of development. These included 268 items and 18 groups, according to the age, and geographical distribution. Results: 1. The range of the normal D.Q. is much wider than that of the physical and skeletal development. 2. The average D.Q. of boys (D.Q.=110,4) was higher than that of girls (D.Q.=108,5) through all age groups, except from 5 to 10 months of age. 3. In comparing the D.Q. of Korean and japanese children, the range of D.Q. among the Korean children was slightly higher than that of Japanese children in all age group. 4. the motor development of Korean infants was somewhat ahead of the American children (infants). 5. The D.Q. of the breast fed children were higher than those of the artificially fed children (D.Q.=112.8: D.Q.=106.9) 6. A comparison of D.Q. was made between 238 orphan children and 336 ordinary children raised in their homes. In this comparison,the D.Q. of the orphan children were lower than those of ordinary children in all age groups. 7. No significant relationship was found either between physical and mental development, or between skeletal maturation and mental development.
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