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식물세포배양에 의한 항암제 Paclitaxel의 대량 생산
최형균,손주선,나광휘,홍승서,박연성,송재영,Choi, Hyung-Kyoon,Son, Joo-Sun,Na, Gwang-Hwee,Hong, Seung-Suh,Park, Yeon-Seung,Song, Jai-Young 한국식물생명공학회 2002 식물생명공학회지 Vol.29 No.1
Samyang Genex succeeded in commercialization of anticancer agent-paclitaxel by plant cell culture technology. The core technology of Samyang Genex relating paclitaxel production includes cell line development, cell line preservation, cell culture, scale-up technology, and purification technology. On the basis of the research, Samyang Genex built the factory operated by CGMP (current good manufacturing practice). The paclitaxel-Genexol$^{TM}$-is commercially available in Korea, and it will be launched to world market including USA after approval of US FDA.
Allylisothiocyanate 첨가가 Aflatoxin 생성 곰팡이 대사산물의 생합성에 미치는 영향
강성조,여명재,이은일,송재영,정덕화 동아시아식생활학회 1996 동아시아식생활학회지 Vol.6 No.1
The effects of allylisothiocyanate on the biosynthesis of various fungus metabolites such as sterigrnatocystin, lipid, protein, citrate RNA and AMP from the culture of Aspergillius parasiticus R-716 were investigated. The content of sterigmatocystin, the precursor of aflatoxin, was lower in the culture added with 50ppm allylisothiocyanate after 48 hours, however was rather higher after 144 hours compared to that of the control. The addition of allylisothiocyanate resulted in the increase of lipid, protein, RNA in mycelium and the content of citrate in the media, but the amount of AMP was low.