精神科 外來患者의 The Self-Rating Depression Scale(SDS)에 關한 硏究

宋玉憲 충남대학교 대학원 1977 論文集 Vol.8 No.-

Author performed the Self-Rating Depression Scale of W.W.K.Zung on 1113 normal subjects and 448 psychiatric out-clinic patients from March 1, 1976 to July 31, 1976. And author classified the test subjects into sexes, four age groups, i.e., under 19, 10 to 39, 40 to 64, and over 65 years, and also different psychiatric diagnoses. Results were made as follow : 1) The Depressive score was not different among age groups and also sex group. 2) In comparison of rank order of the items of the Self-Rating Depression Scale, "Decreased libido" was the highest rank order among normal subjects. And "Confusion" was the highest rank order among total psychiatric out-clinic patients. However "Suicidal rumination" was the lowest rank order in all of the tested groups. 3) Depressive score was significantly higher in the group of depressive neurosis than that of in the group of anxiety neurosis. 4) In comparison of anxiety neurosis, depressive neurosis and nomal subjects, the sore of depression was the significantly high in the female group aged 40 to 65 of depressive neurosis. 5) In involutional melancholia, somatic symptoms tended to be in higher rank order and psychological symptoms in lower rank order. While in all other groups psychological symptoms tended to be in higher rank order and somatic symptoms in lower rank order.

液體 Chromatograph와 放射酵素法에 依한 Catecholamine微量 定量

宋玉憲,申石澈 충남대학교 의과대학 지역사회의학연구소 1983 충남의대잡지 Vol.10 No.2

A direct rapid radioenzymatic assay for measuring simultaneouly picogram quantities of norepinephrine, epinephrine and dopamine by a combination of high pressure liquid chromatography has been developed, and the relationship of changes in cerebrospinal fluid norepinephrine concentrations during haloperidol treatment to changes in psychosis ratings of 12 schizophrenic patients has been investigated. Twenty microliters of cerebrospinal fluid are incubated with catechol-O-methyl-transferase and S-adenosyl-L-[methyl-^3H] methionine to convert the three catechol-amines to their O-methylated analogues. These derivatives are extracted with diethylether containing tetraphenylborate at pH 8.2 followed by re-extraction with 0.1N HCl and then isolated by high pressure liquid chromatography using μ-Bondapak C_18 column and 0.17M acetic acid-6% methanol-0.02M Na_2SO_4 as solvent. Manual collection of each fraction is started two seconds after in appeared mark. The high pressure liquid chromatography fractions of norepinephine (NE) and epinephrine (E) derivatives are oxidized to vanillin followed by extracting the vanillin with toluene, and dopamine (DA) derivative fraction is extracted by toluene/isoamylalcohol and then re-extracted by 0.1N HCl. Owing to a higher recovery (NE, 75.6±0.9%; E, 76±0.8%; DA, 70±0.4% and incorporation rate of radioactivity (NE, 163±11.4; E, 125±10.5; DA, 112±3.9 cpm), together with quick seperation of the methylated derivatives within 8 min by high pressure liquid chromatography, the method yielded extremely high sensitivity (NE, 0.4 pg; E, 0.3 pg; DA, 1 pg), accuracy, reproducibility and specificity of the differential assay, and thus enabled us to complete the differential analysis of 15 samples (30 tubes) in a day. In case of norepinephrine only, more than 35 samples can be assayed in a day. It was shown by this method that haloperidol induced decreases in norepinephrine and that the decreases correlated significantly with psychosis ratings, suggesting that cerebrospinal fluid norepinephrine can be used for evaluation of neuroleptics treatment of schizophrenia.

精神科 外來 患者의 The Self-Rating Depression Scale (SDS)에 關한 硏究

宋玉憲 大韓神經精神醫學會 1977 신경정신의학 Vol.16 No.1

Author performed the Self-Rating Depression Scale of W.W.K. Zung on 1113 normal subjects and 448 psychiatric out-clinic patients from March 1, 1976 to July 31, 1976. And author classified the test subjects into sexes four age groups, ie., under 19, 20 to 39, 40 to 64, and over 65 years, and also different psychiatric diagnoses. Results were made as follows: 1. The Depressive score was not different among age groups and also sex groups. 2. In comparison of rank order of the items of the Self-Rating Depression Scale, "Decreased libido" was the highest rank order among normal subjects. And "Confusion" was the highest rank order among total psychiatric out-clinic patients. However "Suicidal rumination" was the lowest rank order in all of the tested groups. 3. Depressive score was significantly higher in the group of depressive neurosis than that of in the group of anxiety neursis. 4. In cemparison of anxiety neurosis, depressive neurosis and normal subjects, the score of depression was the significantly high in the female group aged 40 to 65 of depressive neurosis. 5. In involutional melancholia, somatic symptoms tended to be in higher rank order and Psychological symptoms in lower rank order. While in all other groups psychological symptoms tended to be in higher rank order and somatic symptoms in lower rank order.

精神科 外來 患者의 The Self-Rating Depression Scale(SDS)에 關한 硏究 (第一編) : 診斷別, 性別 및 年齡別間의 比較 硏究 comparative study among diagnoses, sexes and ages

宋玉憲,申石澈 충남대학교 의과대학 지역사회의학연구소 1977 충남의대잡지 Vol.4 No.1

Author performed the Self-Rating Depression Scale of W.W.K. Zung on 1113 normal subjects and 448 psychiatric out-clinic patients from March 1, 1976 to July 31,1976. And author classified the test subjects into sexes and four age groups, ie., under 19, 20 to 39,40 to 64, and over 65 years, and also different psychiatric diagnosis. Results were made as follows: 1. The depressive score was not different among age groups an also sex groups. 2. In comparison of rank order of the items of the Self-Rating Depression Scale, "Decreased libido" was the highest rank order among normal subjects. And "Confusion" was the highest rank ordr among total psychiatric out-clinic patients. However "Suicidal rumination "was the lowest rank order in all of the tested groups. 3. Depressive score was significantly higher in the group of depressive neurosis than that of in the group of anxiety neurosis. 4. In comparison of anxiety neurosis, depressive neurosis and normal subjects, the score of depression was the significantly high in the female group aged 40 to 65 of depressive neurosis 5. In involutional melancholia, somatic symptoms tended to be in higher rank order and psychological symptoms in lower rank order. While in all other groups psychological symptoms tended to be in higher rank order and somatic symptoms in lower rank order.

환경보전 교육에 대한 소고

송옥헌,Song, Ok-Heon 환경보전협회 1984 환경정보 Vol.6 No.15

환경보전 교육에 대한 소고

송옥헌,Song, Ok-Heon 환경보전협회 1984 환경정보 Vol.6 No.16

한국인의 생활사건에 관한 예비적 연구 Ⅰ. 생활사건 척도

고병학,송옥헌,신윤오 大韓神經精神醫學會 1981 신경정신의학 Vol.20 No.1

For rating emotional responses to the everyday life events, 61 life events were tested by 528 normal persons by the method of paper and pencil questionairs. Among 528 respondents, 300 persons' (men 150, women 150) were selected randomly and the reports were analysed statistically. The results were as follows; 1. Emotional responses of 61 life events were rated and the events were put in rank order according to the mean value of the emotional responses in negative sense. The most negatively responded life events were death of, spouse (M=17.574) and death of child (M=17.481), and the least responded events were many trivial life events and desirable ones in positive sense, e.g. engagement of offsprings (M=2.188) and promotion (M=1.988) etc. 2. Average number of life events which had occurred during one year (1979) was 3.213 in man, 2.580 in woman, and 3.930 in total. 3. Among the occurred life events, death of a member of the family, reunion of separated spouses, hospital admission due to serious illness, involutional period, trivial legal problems, and moving house in the same city were significant by statistically. 4. By factor analysis, it was found that the factor most highly invested emotionally was related to bereavement (M=15.528) and the least invested emotionally was related to to moving house(M=5.824).

精神分裂症의 生物學的 硏究 : 液體 크로마토그라프와 放財酵素法에 依한 Catecholamines 微量定量 A Rapid Microassay of Catecholamines by High Performance Liquid Chromatography-Radioenzymatic Method

고병학,송옥헌,임규,황병두,백문기 中央醫學社 1983 中央醫學 Vol.45 No.4

A direct rapid radioenzymatic assay in combination with high performance liquid chromatography (HPLC) for measuring simultaneously picogram quantities of nore pinephrine, epinephrine and dopamine has been developed, and the relationship of changes in cerebrospinal fluid (CSF) norepinephrine concentration during haloperidol treatment to changes in psychosis rating of twelve schizophrenic patients has been investigated. The three catecholamines in 20?l of CSF are converted to their 0-methylated ana-logues by catechol-0-methyltransferase in the presence of S-adenosyl-L-1{methyl-3H} methionine. After the addition of tetraphenylborate, these derivatives are extracted. with diethylether at pH 8.2 followed by re-extraction with 0.1N HCI and then isol-ated by HPLC using, ?Bondapak C18column and 0.17 M acetic acid-60% methanol- 0.02 M Na2SO4 as solvent. Manual collection of each fraction is started two seconds after in appeared mark. The HPLC fraction of norepinephrine and epinephrine deri-vatives are oxidized to vanillin followed by extracting the vanillin with toluene, and dopamine derivatives fraction is extracted with toluene/isoamylalcohol and then re-extracted with 0.1N HCl. Internal standard curve shows a good linearity from 5 to 30 picogram per samples, and incorporated radioactivity of norepinephrine, epinephrine and dopamine derivatives are 163±11.4, 125±10.5 and 112±3.9cpm per picogram and calculated sensitivities are 0.4, 0.3 and 1 picogram, respectively. 3H-Normetanephrine, 3H-metanephrine and 3H-methoxytytamine are well separated by HPLC, and each retention times are 3.52, 4.08 and 5.62 minutes and yields are 75.6?0.9, 76.1?0.8 and 70.1?0.4%. Separation of the methylated derivatives by HLPC are performed within 8 minutes, and thus enabled us to complete the differential analysis of 15 samples (30 tubes) in a day. CSF norepinephrine concentration in schizophrenic patients show rostral-caudal gradient and haloperidol induced decreases of norepinephrine and the decreases correlated significantly with psychosis rating, From the above rsults, it is suggested that this method is more excellent than any others in sensitivity, accuracy, reproducibility and specificity of the differential assay, and CSF norepinephrine can be used for evaluation of neuroleptics treatment of schizophrenia by this method.

한국인의 생활사건에 관한 예비적 연구 I . 생활사건 척도

고병학,송옥헌,신윤오 대한신경정신의학회 1981 신경정신의학 Vol.20 No.1

For rating emotional responses to the everyday life events, 61 life events were tested by 528 normal persons by the method of paper and pencil questionairs. Among 528 respondents, 300 persons’ (men 150, women 150) were selected randomly and the reports were analysed statistically. The results were as follows; 1. Emotional responses of 61 life events were rated and the events were put in rank order according to the mean value of the em otional responses in negative sense. The most negatively responded life events were death of, spouse (M=17. 574) and death of child (M = 1 7 .481), and the least responded events were many trivial life events and desirable ones in positive sense, e.g. engagement of offsprings (M = 2.188) and promotion (M = 1.988) etc. 2. Average number of life events which had occurred during one year (1979) was 3.213 in man, 2.580 in woman, and 3.930 in total. 3. Among the occurred life events, death of a member of the family, reunion of separated spouses, hospital admission due to serious illness, involutional period, trivial legal problems, and moving house in the same city were significant by statistically. 4. By factor analysis, it was found that the factor most highly invested emotionally was related to bereavement (M=15. 528) and the least invested emotionally was related to to moving house(M=5.824).