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항 - IgG 항체에 의한 차단형 TSH 수용체 항체의 자극형 항체로의 전환
송민호(Min Ho Shong),이가희(Ka Hee Yi),조보연(Bo Youn Cho),이홍규(Hong Kyu Lee),고창순(Chang Soon Koh),민헌기(Hun Ki Min),송영기(Young Kee Shong) 대한내과학회 1991 대한내과학회지 Vol.41 No.5
N/A We examined the conversion phenomenon of thyrotropin rceptor-bound blocking type immunog-lobulin G to the stimulating type by antihuman IgG antibody for the evaluation of the mechanism involved in the conversion, in vitro. Blocking-type IgG was purified from a patient with primary myxedema. In the conversion experiment. FRTL-5 cells were first incubated with blocking-type lgG solution at 37°C for 30 min, then washed with Hanks Balanced Salt Solution and, secondly, incubated with the solution containing antihuman IgG antibody at 4°C for 1.5 h and then for 3 h at 37°C. The antihuman IgG antibody to the cell-bound blocking type IgG resulted in an increase of Camp production in a dose dependent manner. Of the several types of antihuman IgG antibodies tested, antibodies against F fragment and divalent Fab frament showed the most effective conversion, while the least effective were those against the F, fragment. IgG from patients with high titer of rheumatoid factor did not convert cell-bound blocking type IgG to the stimulating type. Antihuman IgG antibody did not interfere with the TBII activity of the blocking type IgG antibody did not interfere with the TBII activity of the blocking type IgG. Simultaneous addition of antihuman IgG antibody and TSH (0.1 Mu/ml) increased Camp production to a greater degree than the individual addition of either. These results suggest that blocking-type TSH receptor antibody and stimulating-type antibody bind to the similar epitope of TSH eceptor, and that IgG against TSH receptor antibodyr may also play a patho-physiological role in vivo.
두부외상후 만성 기질성 정신장애 환자에서 Tc-99m HMPAO Brain SPECT 분석
이강욱,이종진,송민호,강민희,지익성,신영태,노흥규 ( Kang Wook Lee,Jong Jin Lee,Min Ho Shong,Min Hee Kang,Ick Sung Ghi,Young Tai Shin,Heung Kyu Ro ) 대한핵의학회 1994 핵의학 분자영상 Vol.28 No.3
It is well known that Tc-99m HMPAO brain SPECT can reflect the functional lesions better than X-ray computerized tomography(CT) and magnetic resonance imaging(MRI) in the cerebral disorders. In order to evaluate the clinical utilities of Tc-99m HMPAO brain SPECT in patients with post-traumatic chronic organic mental disorder(OMD). We included 28 patients diagnosed as OMD in department of psychiatry after traumatic head injury. And we compared the results of Tc-99m HMPAO SPECT with those of MRI, EEG and MINI mental status examination(MMSE). The results were as follows 1) All patients diagnosed as OMD showed diffuse or focal decreased cerebral perfusion on Tc-99m HMPAO SPECT. 2) Most frequent lession on brain Tc-99m HMPAO SPECT was decreased perfusion on both frontal lobe. And most frequent lesion on brain Tc-99m HMPAO SPECT was decreased perfusion on both frontal lobe. And most frequent lesion on brain Tc-99m HMPAO SPECT showing normal brain MRI result was also decreased both frontal perfusion. 3) Eight of 28 patients showed focal brain MRI lesions(4 small frontal hygroma, 3small cerebral infarction and 1 cerebellar encephalomalacia) which were not detected in brain Tc-99m HMPAO SPECT. 4) The patients showing less than 20 points on MMSE disclosed abnormal results of EEG more frequently than those disclosing more than 20points. In conclusion, we think that Tc-99m HMPAO brain SPECT is sensitive method to detect functional lesions of the brains in patients with chronic post-traumatic organic mental disoder.
갑상선유두암 재발 진단에서 18F-FDG PET/CT와 경부초음파검사 병용의 유용성: PET, 경부초음파검사 그리고 혈청 티로글로불린 (thyroglobulin)의 비교
김근호 ( Kun Ho Kim ),송민호 ( Min Ho Shong ),서영덕 ( Young Duk Seo ),김성민 ( Seong Min Kim ) 대한핵의학회 2009 핵의학 분자영상 Vol.43 No.5
목적: 이 연구의 목적은 갑상선유두암 환자를 대상으로 재발의 진단에서 18F-FDG PET/CT와 경부초음파검사를 함께 시행하는 것에 대한 유용성을 평가하고자 한다. 대상 및 방법: 2006년 12월부터 2008년 4월까지 갑상선유두암으로 갑상선 전절제술 및 고용량의 방사성옥소 치료를 시행 받은 환자 중에서 재발이 의심되어 18F-FDG PET/CT를 시행한 61명(91건)을 대상으로 후향적으로 연구를 진행하였다. 의심되는 병소는 조직검사를 시행하였고, 조직 검사결과와 PET 검사결과, PET/CT 검사결과, 경부초음파검사 결과를 비교하였다. 결과: 18F-FDG PET/CT (여자 57명, 남자 4명; 연령 범위, 24-81세, 평균 49세; 유두암 61개)의 민감도, 특이도, 정확도는 각각 환자 기준으로 87.2%, 59.0%, 77.0%였고, 병소 기준으로 92.3%, 64.1%, 80.2% 였다. 18F-FDG PET의 민감도, 특이도, 정확도는 각각 환자 기준으로 71.8% (p=0.03), 59.0% (p=1.00), 67.2% (p=0.03)였고, 병소 기준으로 78.8% (p=0.01), 64.1% (p=1.00), 72.5% (p=0.02)였다. 경부초음파검사의 경우 민감도, 특이도, 정확도는 각각 환자 기준으로 71.1% (p=0.07), 52.2% (p=0.75), 63.9% (p=0.08)였고, 병소 기준으로 71.2% (p<0.01), 61.5% (p=1.00), 67.0% (p=0.06)였다. 18F-FDG PET/CT와 경부초음파검사를 함께 판독한 경우 민감도, 특이도, 정확도는 각각 환자 기준으로 94.7% (p=0.50), 82.6% (p=0.13), 90.2% (p=0.03)였고, 병소 기준으로 96.2% (p=0.50), 89.7% (p<0.01), 93.4% (p<0.01)였다. 결론: 18F-FDG PET/CT는 갑상선유두암의 재발 진단에서 18F-FDG PET와 경부초음파검사와 비교하여 높은 민감도, 특이도, 정확도를 보였다. 게다가 18F-FDG PET와 경부 초음파를 함께 시행한 경우 갑상선유두암의 재발 진단에 있어서 더욱 향상된 민감도, 특이도, 정확도를 보였다. Purpose: The aim of this study was to investigate the usefulness of 18F-FDG PET/CT with neck ultrasonography (neck US) in patients with recurrent, papillary thyroid cancer. Material and methods: This retrospective study (December 2006 to April 2008) enrolled sixty-one patients (ninety-one lesions) who underwent high-dose 131I-ablation therapy after total thyroidectomy, and evaluated recurred papillary thyroid cancer. All lesions were confirmed by histopathology and compared histopathologic findings to PET, PET/CT, and neck US findings. Results: In sixty-one patients (57 women, 4 men; age range, 24-81 years, mean 49 years; 61 papillary carcinomas), the sensitivity, specificity, accuracy of 18F-FDG PET/CT was 87.2%, 64.0%, 78.1% on a patient basis and 92.3%, 66.7%, 80.9% on a lesion basis, respectively. The sensitivity, specificity, accuracy of 18F-FDG PET was 71.8% (p=0.03), 59.0% (p=1.00), 67.2% (p=0.03) on a patient basis and 78.8% (p<0.01), 64.1% (p=1.00), 72.5% (p=0.02) on a lesion basis, respectively. The sensitivity, specificity, accuracy of neck US was 71.1% (p=0.07), 52.2% (p=0.75), 63.9% (p=0.05) on a patient basis and 71.2% (p<0.01), 61.5% (p=1.00), 67.0% (p=0.06) on a lesion basis, respectively. Combined 18F-FDG PET/CT with neck US improved the sensitivity, specificity, accuracy to 94.7% (p=0.50), 82.6% (p=0.13), 90.2% (p=0.03) on a patient basis and 96.2% (p=0.50), 89.7% (p<0.01), 93.4% (p<0.01) on a lesion basis, respectively. Conclusion: 18F-FDG PET/CT demonstrated significantly higher sensitivity than neck US for the detection of recurred papillary thyroid cancer lesions. Furthermore, combined 18F-FDG PET/CT with neck US showed more improved sensitivity, specificity, accuracy for diagnosis of recurrent papillary thyroid cancer. (Nucl Med Mol Imaging 2009;43(5):411-420)
갑상선자극호르몬에 의한 분자\ulcorner페론 ERp29 유전자의 발현
박수정,이웅희,구태원,윤은영,황재삼,김호,송민호,권오규,Park, Soo-Jung,Lee, Woong-Hee,Goo, Tae-Won,Yun, Eun-Young,Hwang, Jae-Sam,Kim, Ho,Shong, Min-Ho,Kwon, O-Yu 한국생명과학회 2000 생명과학회지 Vol.10 No.2
This experiment was performed to evaluate the effect of TSH (thyroid-stimulating) on the ERp29 (endoplasmic reticulum resident 29 kDa protein) gene expression in the rat thyrocytes of FRTL-5 cells. Although ERp29 mRNA was constantly expressed, its expression began to increase remarkably from 10-9 M TSH. and its maximum expression was at 5×10-9 M TSH (about 3.5 fold). On the other hand, the effect of TSH on the abundance of ERp29 mRNA started within 6 h, and peaked at 8 h (about 2.5 fold). Actinomycin D (transcription inhibitor) strongly blocked this effect while cycloheximide (translation inhibitor) did not. The half-life of ERp29 mRNA was about 4.5 h in the presence or absence of TSH that was not affected by the stability of ERp29 mRNA. The effect of TSH on the ERp29 gene expression was specific, while other growth factors (transfferin, insulin, and hydrocortisone) did not alter its expression. Our data indicate for the first time that the expression of ERp29 is regulated transcriptionally by TSH in the thyrocytes.
갑상선 세포의 성장에 대한 TSH 및 IGF - I 의 신호전달 과정에서 백일해 독소 예민성 G - 단백의 역할
조보연(Bo Youn Cho),이동수(Dong Soo Lee),이가희(Ka Hee Yi),송민호(Min Ho Shong),이홍규(Hong Kyu Lee),고창순(Chang Soon Koh),민헌기(Hun Ki Min) 대한내과학회 1991 대한내과학회지 Vol.41 No.1
N/A To evaluate the effect of pertussis toxin sensitive G-proteins on the growth of thyrocytes by TSH and IGF-I, we measured 3H-thymidine incorporation into FRTL-5 cells stimulated by TSH and/or IGF-I. Thymidine incorporation into FRTL-5 cells by TSH(1 mU/ml) or IGF-I (10 ng/ml) was significantly inhibited by the pretreatment of pertussis toxin (25 ug/ml). Adenosine (1mM) inhibited both TSH-and IGF-I- stimulated thymidine incorporation into FRTL-5 cells and the synergistic effect of TSH and IGF-I. This inhibitory effect of adenosine on TSH-or 1GF-I-stimulated thymidine incorporation was blocked partially by the pretreatment of pertussis toxin. However, the inhibition of the synergism of TSH and IGF-I by adenosine was not altered by the pretreatment of pertussis toxin. Indomethacin (100 uM) inhibited TSH effects by 60% and inhibieed IGF-1 effects by 5096 at 24 hours of incubation and then enhanced IGF-I effects in the prolonged incubation. Indomethacin blunted the synergism of TSH and IGF-I. These inhibitory effects of indomethacin were altered by the pretreatment of pertussis toxin. The pretreatment of pertussis toxin did not affect the inhibitory effect of indomethacin on the synergism of TSH and IGF-I at 24 hours of incubation. However, in the prolonged incubation (72 hours) the pretreatment of pertussis toxin significantly blocked the indomethacin effect. These findings suggest that pertussis toxin-sensitive G-proteins are involved in the signal transduction of TSH and/or IGF-1-stimulated growth of FRTL-5 cells and arachidonate metabolites should be involved in the mediation of synergism of growth stimulation induced by TSH and IGF-l in FRTL-5 cells.
이강현(Kang Hyun Lee),안봉수(Bong Soo An),이진홍(Jin Hong Lee),안미애(Mee Ae Ahn),송치운(Chi Un Song),송민호(Min Ho Shong),노홍규(Heung Kyu Ro) 대한내과학회 1996 대한내과학회지 Vol.50 No.2
N/A causing Graves` disease and the soluble form of ICAM-1 are markedly elevated in the sera from patients with Graves` disease