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반월상 연골 재생을 위한 친수화 처리 폴리다이옥사논 지지체의 제조 및 분석
조광준 ( Kwang Joon Cho ),송대근 ( Dae Kun Song ),오세행 ( Se Heang Oh ),고영주 ( Young Joo Koh ),이상훈 ( Sahng Hoon Lee ),이명철 ( Myung Chul Lee ),이진호 ( Jin Ho Lee ) 한국조직공학과 재생의학회 2005 조직공학과 재생의학 Vol.2 No.2
Biodegradable polymers have been widely used to fabricate porous scaffolds for three-dimensional (3-D) cell cultures to regenerate tissue-based artificial organs. Until now, poly(L-lactic acid), poly(glycolic acid), and poly(lactic-co-glycolic acid) as synthetic biodegradable polymers have been most widely used to fabricate 3-D scaffolds. However, these polymers have limitations for some applications because of their brittleness, hydrophobicity, and low cell adhesiveness. Recently polydioxanone (PDO) has been interested in the applications for tissue regeneration since this polymer has good elasticity as well as biocompatibility and biodegradability. However, porous scaffold fabrications from PDO were limited due to its poor solubility (solvents to dissolve PDO are few). In this study, we firstly fabricated porous PDO scaffolds (disc and meniscus shapes) using a melt-molding particulate-leaching method developed by our laboratory. This method does not need any solvents during the fabrication process. To improve the hydrophilicity and cell compatibility of the scaffolds, PDO was blended with polyvinyl alcohol (PVA) with different ratio. The hydrophilicity, morphology, porosity, and mechanical properties of the prepared PDO scaffolds were investigated. The PDO/PVA (5 wt%) blend scaffold was found to have sufficient hydrophilicity, mechanical strength, and elasticity for tissue engineering applications including meniscus regeneration.