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      • SCOPUSKCI등재

        그레이브스 갑상선기능항진증 환자의 방사성옥소 ( 131I ) 치료시 실제 유효반감기의 측정

        김종순(Chong Soon Kim),김은실(Eun Sil Kim),소용선(Yong Seon So),김명선(Myung Seon Kim),권기현(Ki Hyun Kwon),김석환(Seok Whan Kim),김태형(Tae Hyung Kim),한상웅(Sang Woong Han) 대한핵의학회 1996 핵의학 분자영상 Vol.30 No.1

        N/A Radioiodine[131I] has been used for the treatment of Graves' hyperthyroidism since the late 1940's and is now generally regarded as the treatment of choice for Graves' hyperthyroidism who does not remit following a course of antithyroid drugs. But for the dose given, several different protocols have been described by different centers, each attempting to reduce the incidence of long-term hypothyroidism while maintaining an acceptable rate control of Graves' hyperthyroidism. Our goals were to evaluate effective half-life and predict absorbed dose in Graves' hyperthyroidism patients, therefore, to calculate and readminister radioiodine activity needed to achieve aimed radiation dose. Our data showed that the mean effective 131I half-life for Graves' disease is 5.3 days(S.D=0.88) and mean biologic half-life is 21 days, range 9.5-67.2 days. The mean admininistered activity and the mean values of absorbed doses wert: 532 MBq(S.D.=254), 112 Gy (S.D.=50.9), respectively. The mean activity needed to achieve aimed radiation dose were 51 MBq and marked differences of 131I thyroidal uptake between tracer and therapy ocurred in our study. We are sure that the dose calculation method that uses 5 days thyroidal 131I uptake measurements after tracer and therapy dose, provides sufficient data about the effective treatment in Graves' hyperthyroidism

      • SCOPUSKCI등재

        전기화상에서 골스캔의 유용성

        김종순(Jong Soon Kim),한승수(Seung Soo Han),소용선(Yong Seon So),김태형(Tae Hyung Kim),한상웅(Sang Woong Han),권기현(Ki Hyeon Kweon),김석환(Seok Hwan Kim) 대한핵의학회 1996 핵의학 분자영상 Vol.30 No.1

        N/A Bone scan is known to be an effective tool for observing the state of soft tissues and bones of electric bum patients. It is also used for observing the progress of patients after debridement or skin graft as well as determing to amputate specific body parts. To evaluate bone scan's role in electric bum, we analyzed bone scan 37 patients with electric burn. Among the 37 patients, 8 of 37 were injured in low voltage and 29 of them in high voltage. 27 patients received the electrical input through the hand, 6 through the scalp, 2 through the shoulder, 1 through the left chest wall and 1 through the left inguinal area. Among 29 patients received high voltage, 22 patients had the electrical output through the foot, 3 through the hand, 2 through the shoulder, 1 through the buttock and 1 through the left chest wall. Bone scans revealed cellulitis in 37 patients with 47 sites, osteomyelitis in 15 patients with 15 sites & bone defects in 4 patients with 4 sites. In 4 patients with skin graft or skin flap, follow up bone scan showed improvements of bony uptake in preoperatively bony defect area and all of them were healed without complication There were 2 cases in which uptake increased in the myocardium, 1 in the liver and 6 in the kidney, however, ssrum calcium level, EKG, cardiac enzyme, liver and renal function tests were normal. In conclusion, bone scans are helpful in the assessment of injury sites after electrical insult and in differential diagnosis of cellulitis and osteomyelitis. It is also useful tool of assessment after skin graft or skin flap, however, it should be further evaluated about internal organ damage.

      • SCOPUSKCI등재

        하시모토갑상선엽에 병발한 유두상 갑상선암 1예

        김종순,김석환,한상웅,김광회,소용선,권기현,이병두,김태형 대한내분비학회 1996 Endocrinology and metabolism Vol.11 No.2

        The association of thyroid carcinoma and Hashimoto's thyroiditis in same thyroid gland is controversial. Incidence of carcinoma who has Hashimoto's thyroiditis has been reported from 0.5 to 22.5 per cent by Crile and by Hirabayashi et al. The reason that there are such great differences in the reported incidences of carcinoma in Hashimotos disease is the result of the way the material is reported. The carcinomas of the thyroid which occur in association with Hashirnoto's thyroiditis are predominently papillary tumors of lower grade malignancy. Thyroid carcinoma need not be feared in patients with Hashimoto's thyroiditis, if one examines the gland carefully. When patients with Hashimoto's disease are treated with thyroxine, there is little or no tendency for Hashimoto's disease progress to clinically detectable carcinoma of the thyroid, and the microcarcinoma does not appear. In this case, single thyroid nodule was detected in Hashiimoto's disease patient who was treated with thyroxine. There was no significant volume change of thyroid nodule despite of TSH suppression therapy during six months. Therefore we performed FNABC twice, the results were highly suspicious thyroid malignancy and subtotoal thyroidectomy was performed. The final pathologic result was microscopic papillary carcinoma with background Hashlmoto's thyroiditis. In conclusion, we experienced a case of subsequent microscopic papillary carcinoma of the thyroid in patient with Hashimoto's thyroiditis who was TSH suppression therapy with thyroxine(J Kor Soc Endocrinol 11:214 ~220, 1996).

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