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서성석,조미영,김미란,황경주,김영아,유희석,Seo, Seong-Seog,Jo, Mi-Yeong,Kim, Mi-Ran,Hwang, Kyung-Joo,Kim, Young-Ah,Ryu, Hee-Sug 대한생식의학회 2003 Clinical and Experimental Reproductive Medicine Vol.30 No.1
Objective : To evaluate the safety and efficacy of selective fetal reduction (SFR) and compare the outcome of twin pregnancy after SFR in multiple pregnancy induced by assisted reproductive technology (ART) with that of natural twin pregnancy. Methods : From September 1995 to March 2002 in Ajou University Hospital, SFR was performed in 79 patients whose gestational sacs were more than 3. Of these 79 patients, 47 patents resulted in twin pregnancy after SFR. SFR was performed using transvaginal intracardiac KCl injection at gestational age of $6{\sim}9$ weeks. Control group was composed of 264 patients with natural twin pregnancy, who delivered after intrauterine pregnancy at 24 weeks, from June 1994 through December 2002. We compared Obstetric and perinatal outcomes between SFR group and natural twin group. Results: Among 47 patients with twin pregnancy after SFR, 2 spontaneous abortion were occurred at intrauterine pregnancy at 8 and 19 weeks. Obstetrical and perinatal outcomes were available in 43 patients. Single intrauterine fetal death was occurred in 1 of 43 (2.3%) patients in SFR group. Incidence of preterm labor, premature rupture of membrane, preeclampsia and placenta previa were similar, but gestational diabetes mellitus (GDM) was occurred more frequently in SFR group (3 (7.0%) vs 4 (1.5%), p=0.02). Mean gestational age, mean birth weight, incidence of discordancy, use of intubation and ventilation, incidence of fetal anomaly, low (<7) Apgar score and intrauterine growth restriction were similar in both groups. Conclusion: Twin pregnancy after SFR has the increased incidence for GDM but other obstetric and perinatal outcome was similar compared with natural twin pregnancy. So SFR is a safe and effective procedure, so we suggest SFR is needed in multifetal pregnancy more than triplet.
양성천 ( Seong Cheon Yang ),김행수 ( Haeng Soo Kim ),양정인 ( Jeong In Yang ),이희종 ( Hee Jong Lee ),안상태 ( Sang Tae Ahn ),서성석 ( Seong Sug Seo ),유희석 ( Hee Sug Ryu ) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.11
목적: 임신성 당뇨의 진단기준을 낮추는 것이 미치는 효과를 밝히고자 하였다. 연구 방법: 임신 24-28주에 시행한 50 gm 경구 당부하검사상 혈장 혈당치가 130 mg/dl 이상인 산모에게 임신 28-32주에 100 gm 경구 당부하검사를 시행하였다. Carpenter-Coustan과 NDDG의 임신성 당뇨에 대한 진단기준을 적용하여, 대조군: 50 gm 경구 당부하검사상 정상군 (n=268), Borderline 군: Carpenter-Cousta Objective: To determine the effect of lowering the cutoff values of 3-hour oral glucose tolerance test (OGTT) for gestational diabetes mellitus (GDM). Methods: Patients with an abnormal 50 gm glucose challenge test (GCT) of more than 130 mg/dL at 24-28 we
정상 자궁난관조영을 보이는 불임 환자에 있어서 복강경술의 의의
권종희 ( Jong Hee Kwon ),서성석 ( Seong Seog Seo ),김미란 ( Mi Ran Kim ),황경주 ( Kyung Joo Hwang ),장혜진 ( Hye Jin Chang ),장석준 ( Suk Joon Chang ),유희석 ( Hee Sug Ryu ) 대한산부인과학회 2005 Obstetrics & Gynecology Science Vol.48 No.2
목적: 불임의 원인을 정확히 찾아내어 그 원인에 따라 적절한 치료 계획을 세워 성공적으로 임신에 도달하는 것이 불임 검사의 목적이다. 자궁난관조영술은 난관내부 및 자궁내강의 환경을 평가하는데 유용한 방법이기는 하나 난관주변의 유착 및 자궁내막증과 같은 골반강내 질환 등의 진단에는 한계가 있다. 본 연구는 경상 자궁난관조영을 보인 불임환자에서의 복강경술의 의의를 알아보고자 한다. 연구 방법: 본 연구에서는 후향적으로 79명의 자궁난관 조영술상 정상을 보인 Objective: To evaluate the value of laparoscopy in infertile women with normal hysterosalpingograms. Methods: Retrospectively analyzed the laparoscopic findings of 79 infertility patients with normal hysterosalpingograms. Results: Of the 79 patients, 28 (
자궁내막증 환자의 체외수정시술시 저용량 aspirin 과 corticosteroid 치료의 효용성에 관한 연구
김영아(Young Ah Kim),김미란(Mi Ran Kim),황경주(Kyung Joo Hwang),윤종혁(Jong Hyuck Yoon),서성석(Seong Seog Seo),유희석(Hee Sug Ryu) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.3
N/A Objective: To investigate the efficacy of low-dose aspirin and corticosteroid in IVF-ET patients with endometriosis. Materials and Methods: 45 infertile patients with endometriosis underwent 59 consecutive IVF-ET cycles. In the treatment group, 18 patients (23 cycles)underwent controlled ovarian hyperstimulation (COH) and received daily doses of 80 mg of aspirin and 15 mg of prednisone, startingon 3rd day of COH. In the control group, 27 patients (36 cycles)underwent COH without treatment. We analyzed the clinical characteristics, fertilization rates, good quality embryo ratio and pregnancy rates Results: There was no difference between groups in clinical characteristics (mean age, parity, LH, FSH, estradiol, progesterone), fertilization rates, and good embryo ratio. However, implantation rates were significantly different (29.81%vs.11.06%,p=0.019). Furthermore, hCG positive rates (60.89%vs.41.67%), clinical pregnancy rates (56.52%vs.33.33%), and on going pregnancy rates (>20weeks)(47.83%vs.27.78%) were increased in the study group compared to the control group. Conclusions: Combined treatment of low dose aspirin and prednisone improved pregnancy rates and implantation rates in IVF-ET patients with endometriosis. This results confirm the hypothesis that autoantibodies subsequently react with endometrial antigen leading to implantation failure and that we need to further research to the relationship of endometriosis with the immunologic aspect of implantation.