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청혈플러스가 혈관내피세포에서 염증 지표인자에 미치는 영향
서동효,주인환,김동희 大田大學校 附屬 韓方病院 2018 惠和醫學 Vol.27 No.2
Objectives : Coronary and cerebrovascular disease with high mortality is a major factor in arteriosclerosis. Pro-inflammatory cytokines damage vascular endothelial cells, leading to vascular inflammation. These vascular inflammation can build up cholesterol and thrombus to cause atherosclerosis. Methods : In this study, we researched the effect of ChungHyul-Plus for vascular inflammation in human umbilical vein endothelial cells (HUVECs) stimulated with tumor necrosis factor-α (TNF-α). Change in mRNA expression of inflammatory cytokines (CCL5, CXCL8, CX3CL1, and MCP-1), cell adhesion molecules (VCAM-1 and ICAM-1), and anti-inflammation modulators (KLF2 and eNOS) were quantified by qRT-PCR. Results : ChungHyul-Plus decreased expression of inflammatory cytokines and cell adhesion molecules and increased anti-inflammation modulators expression in TNF-α stimulated HUVECs. Conclusions : These results suggest that ChungHyul-Plus can be used in the treatment and prevention of vascular inflammation and arteriosclerosis.
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청혈플러스가 혈관내피세포에서 염증 지표인자에 미치는 영향
서동효,주인환,김동희,Seo, Dong-hyo,Joo, In-Hwan,Kim, Dong-Hee 대전대학교 한의학연구소 2018 한의학연구소 논문집 Vol.27 No.2
Objectives : Coronary and cerebrovascular disease with high mortality is a major factor in arteriosclerosis. Pro-inflammatory cytokines damage vascular endothelial cells, leading to vascular inflammation. These vascular inflammation can build up cholesterol and thrombus to cause atherosclerosis. Methods : In this study, we researched the effect of ChungHyul-Plus for vascular inflammation in human umbilical vein endothelial cells (HUVECs) stimulated with tumor necrosis $factor-{\alpha}$ ($TNF-{\alpha}$). Change in mRNA expression of inflammatory cytokines (CCL5, CXCL8, CX3CL1, and MCP-1), cell adhesion molecules (VCAM-1 and ICAM-1), and anti-inflammation modulators (KLF2 and eNOS) were quantified by qRT-PCR. Results : ChungHyul-Plus decreased expression of inflammatory cytokines and cell adhesion molecules and increased anti-inflammation modulators expression in $TNF-{\alpha}$ stimulated HUVECs. Conclusions : These results suggest that ChungHyul-Plus can be used in the treatment and prevention of vascular inflammation and arteriosclerosis.
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Cable TV 홈쇼핑 이용자들의 여행 상품권 구매행동에 관하여
서동효 한국관광서비스학회 2007 한국관광서비스학회 학술대회 Vol.- No.동계
Cable TV Home Shopping is one of the popular distribution channels in modem society because of purchasing convenience and saving in shopping time. However, in spite of these advantages, there are some problems because of marketing strategies of many Cable TV shopping companies which stimulate impulse purchases. The findings of this study provide useful information for hospital industries promotions of Cable TV home shopping.
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천연물 복합제가 제 2형 당뇨 마우스에서 혈당 및 지질대사에 미치는 영향
서동효,주인환,김동희,Seo, Dong-hyo,Joo, In-Hwan,Kim, Dong-Hee 대전대학교 한의학연구소 2020 혜화의학회지 Vol.29 No.2
Objectives: This study aims to investigate the effects of diabetes mellitus care mixture (DCM) on blood glucose and lipid metabolism in type 2 diabetic mellitus mice. DCM consisted of lagerstroemia speciose, allium hookeri, momordica charantia, amaranthus tricolor, and boesenbergia rotunda, which have been proven to have antidiabetic properties. Methods: In this study, we researched the effects of DCM in type 2 diabetic mellitus mice. C57BLKS/J mouse groups had no treatment, db/db mouse randomly assigned to 2 groups, and treated with distilled water and DCM (200 mg/kg/day). Blood glucose levels and body weight were checked every week. After 4 weeks of treatment, liver function indicators (AST, ALT, and LDH) and lipid metabolites (triglyceride, total cholesterol, LDL-cholesterol, HDL-cholesterol) were measured with a biochemistry analyzer. Diabetic factors (insulin, resistin, and leptin) were measured with ELISA. Results: DCM was decreased blood glucose, diabetic factors, liver function indicators, triglyceride, total cholesterol, and LDL-cholesterol significantly. Also, HDL-cholesterol was significantly increased in DCM group. The bodyweight of DCM group decreased but, no significant difference with the control group. DCM may have the potential to improved diabetes mellitus by regulating blood glucose levels and diabetic factors. Also protecting from diabetic complications by adjusting liver function indicators and lipid metabolites. Conclusions: These results suggest that DCM to be used as an oriental medicine for diabetes, the results of clinical trials are needed.
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천연물 복합제가 제 2형 당뇨 마우스에서 혈당 및 지질대사에 미치는 영향
서동효,주인환,김동희 大田大學校 附屬 韓方病院 2020 惠和醫學 Vol.29 No.2
objective: This study aims to investigate the effects of diabetes mellitus care blood glucose and lipid metabolism in type 2 diabetic mellitus mice. DCM consis temdi xotfu rlea g(eDrsCtrMo)e moina shpavecei obseee, n apllriouvme nh otoo khearvi,e manotmidoiradbiectai c cphraorpanetritaie, sa.maranthus tricolor, and boesenbergia rotunda, which CM5e7thBoLdKsS: /JI nm otuhsise gsrtouudpys, hwaed nroe steraeracthmeedn tt, hdeb /debff emctosu seo f raDnCdoMm lyin astsyipgen ed2 tod ia2b egtriocu pms,e lalintdu s tremaitceed. ewvitehr yd iwsteiellke.d Awfateter r 4a nwde eDkCsM o f( 2tr0e0a t㎎me/㎏nt/, daliyv)e.r Bfulonocdt iognl ucinodsiec alteovrse ls( AaSnTd , bAodLyT ,w aenigdh tL DwHe)re acnhde clikpeidd bmieotcahbeomliitsetsr y( tarnigallyyczeerr.i dDe,i atboettailc cfhaoctleosrste r(oinl,s uLlDinL, -recshioslteisnt, earnodl, lHeDptLin-)c hwoeleres temreoal)s uwreedr ew mithe aEsuLrIeSdA .with a tRoetsaul ltcsh:o lDesCtMer olw, aasn dd eLcDrLea-scehdo lebslotoedro lg lsuigconsifeic, andtialyb.e tAicl sof,a cHtoDrLs,- clihvoelre sftuenroclt iowna si nsdiigcnaitfoicrasn, tltyr iginlyccreeraisdeed, icno nDtrColM g rgoruopu. pD. CTMh em bayod yhawveei gthhte opfo tDenCtMia l gtoro uimp prdoevcerde adsieadb ebteust, mneol litsuigsn ibfyic arnetg udlaiftfinegre nbcloeo dw gitlhu cothsee ilendvieclast oarnsd anddia blieptiidc mfaectatobrosli.t eAs.l so protecting from diabetic complications by adjusting liver function rCeosnuclltuss ioofn sc:l inTichaels etr iarelss ualrtes nseuegdgeeds.t that DCM to be used as an oriental medicine for diabetes, the result of clinical trials are needed
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