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벤조디아제핀과 수면제한이 정신운동기능에 미치는 영향에 대한 예비연구
변준형(Joon-Hyeong Byun),배경열(Kyung-Yeol Bae),진유양(You-Yang Jin),강희주(Hee-Ju Kang),이주연(Ju-Yeon Lee),김성완(Sung-Wan Kim),김재민(Jae-Min Kim),신일선(Il-Seon Shin),김선영(Seon-Young Kim),윤진상(Jin-Sang Yoon) 대한생물치료정신의학회 2014 생물치료정신의학 Vol.20 No.2
Objectives:The use of benzodiazepine and sleep deficiency both impair psychomotor function. Individuals with insufficient sleep often take benzodiazepine during the day for various reasons, such as anxiety. However, few studies have examined the extent to which the psychomotor effects of benzodiazepine interact with insufficient sleep. Therefore, this study examined the interaction of benzodiazepine and sleep deprivation on psychomotor function in healthy young males. Methods:Four healthy males(age 23-26 years) participated in this study. Using a double-blind, placebo-controlled, crossover design, each subject was administered one of the following four conditions in a random order at 1-week intervals : 8 h in bed–placebo ; 8 h in bed–0.5 mg lorazepam ; 4 h in bed–placebo ; or 4 h in bed–0.5 mg lorazepam. Psychomotor functions were assessed at baseline and five times over 8.5 h after taking the study medications using the Critical Flicker Fusion Threshold, Choice Reaction Time, Compensatory Tracking Task, Digit Symbol Substitution Test, and Color-Word Stroop Tests. Results:On the Color Stroop Test, there were significant differences among the conditions at 6.5(T4)(χ2=8.100, p= 0.044) and 8.5(T5)(χ2=8.100, p=0.044) h post-dose. In post hoc tests, 4 h in bed–0.5 mg lorazepam tended to cause more impairment than the other conditions. Conclusion:There was some evidence that benzodiazepine-induced psychomotor impairment is potentiated by sleep deprivation. Future studies with larger sample sizes are required to validate this finding.