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제2형 당뇨병 환자에서 App E 지단백 유전자형 다형성과 혈청 지질과의 관계
류완희,염정필,김용성,윤경하,이규호,박지현,김현각,박태선,백흥선,김달식 의과학연구소 2000 全北醫大論文集 Vol.24 No.2
Background and purpose : Apolipoprotein E (apo E) has important function for lipoprotein metabolism as a low density lipoprotein (LDL) receptor and hepatic apo E receptor. Apo E has three isoforms, E2, E3 and E4. The purpose of this study is to evaluate the serum lipid profile depending on apo E genotype in the type 2 diabetic patients. Materials and Methods : Two hundred thirty four type 2 diabetic patients and ninty four controls were included in this study. The serum lipid profiles were measured and apo E genotypes were determined by modified Amplification Refractory Mutation system (ARMS) and classified into E2, E3 and E4 subgroups. Results : The apo E genotype frequencies in type 2 diabetic patients were as follows; 70.9% for ε3/3, 15.0% for ε3/4, 8.5% for ε3/2, 2.1% for ε2/2, 2.1% for ε4/4, 1.3% for ε2/4. The calculated apo E allele frequencies were 0.069 for ε2, 0.819 for ε3, 0.112 for ε4. There were no significant differences betwwen type 2 diabetic patients and controls in apo E genotype, and allele frequencies. Mean level of the serum HDL-cholesterol was significantly lower in E4 group than E2 and E3. The subjects with apo ε4 allele had sgnificantly lower level of HDL-cholesterol than the subjects without ε4 allele and subjects with apo ε2 were associated with higher level of LDL-cholesterol and of triglyceride in type 2 diabetic patients. Conclusion : Apo E polymorphism plays an important role in dtermining individual differences in serum lipid level in type 2 diabetic patients.