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전소영(So-Young Chun),배옥석(Ok-Suk Bae),김종봉(Jong-Bong Kim) 대한의생명과학회 1998 Biomedical Science Letters Vol.4 No.2
본 연구에서는 genomic DNA 전기영동과 TUNEL labeling법을 이용하여 정상대장조직, 대장암조직, 대장암인접림프절조직과 대장암환자 혈액에서 apoptosis 발현을 분석하였다. 정상대장조직 37례중 4례에서, DNA ladder가 확인되었고, 암조직은 47례중 20례에서, 림프절조직은 15례중 5례에서 나타났으며 대장암환자혈액은 7례 모두에서 발현되지 않았다. TUNEL labeling법을 이용한 조직상의 in situ apoptosis 발현은 암조직과 림프절조직에서 확인되었다. 따라서 본 연구에서는 대장암이 진행됨에 따라 apoptosis 발현비가 증가되었으므로 apoptotic index가 대장암 발현과 관련되어 있는 듯 하며 예후예측지표자로서 이용될 가능성이 있다고 사료된다. We studied on the expression of apoptosis in colorectal cancer, lymph node, their corresponding normal mucosa and colorectal cancer patient's blood by genomic DNA electrophoresis and TUNEL labeling method. From 7 cases among 37, 20 cases among 47 and 5 cases among 15, DNA ladders were expressed in normal tissues, colorectal tissues and lymph node tissues, respectively. A DNA ladder was not observed in 7 cases of colorectal cancer patients blood. In case of TUNELlabeling, we could observe TUNEL color espression in colorectal cancer and lymph node tissues. As these result suggest that apoptotic index may be associated with the colorectal cencer development, and mat be used as a prognostic indicator but further evaluations will be needed.
폐쇄성 대장암 환자에서 스텐트 삽입술 후 발생한 복부구획 증후군
백성규(Seong Kyu Baek),배옥석(Ok Suk Bae),박성대(Sung Dae Park) 대한외과학회 2008 Annals of Surgical Treatment and Research(ASRT) Vol.75 No.5
Colonic stenting has been suggested as an acceptable therapeutic option for the palliation of malignant colorectal obstruction or to achieve bowel decompression and preparation. It is effective as a bridge to surgery that is useful as an option to avoid emergency colostomy. However, it is associated with complications such as intestinal perforation, stent migration, bleeding, and failure of bowel decompression. Of all the complications, intestinal perforation and failure of bowel decompression are most serious and require surgical treatment. Here we report a case of abdominal compartment syndrome after stent insertion for obstructive colon cancer. The main causative factors for abdominal compartment syndrome were bowel distension associated with endoscopic gas inflation and failure to achieve bowel decompression.