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Choi, Sun-Woong,Lee, Jin-Ho,Lee, Kyu-Hee,Bang, Sung-Jin,Ahn, Jong-Sung,Lee, Keun-Hyung,Chung, Kyeong-Soo,Oh, Jung-Yeon,Kim, Jin-Hyang,Yang, Joon-Mook,Noh, Seung-Moo,Min, Byung-Moo,Kim, Young-Beak,Kim, 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1
A method for processing and the drug releasing behavior of 5-Fluorouracil(5FU)/ Polyglycolic Acid(PGA) composite, applicable to medical devices, was investigated. A preliminary results indicated that the method utilizing melt processing could be a simple means by which the composite can be processed without referring to more involved and difficult-to-achieve solvent processing method. It is shown that the effectiveness of 5-FU was maintained during tests, even after the processing temperature of 230℃. The release patterns from the various sized samples have indicated that the observed release may have occurred in one or two stages, depending on the sample thickness and that a longer experimental times may be required to elucidate the complete release pattern. Although a further and more detailed analysis need to be performed to better understand the controlled release behavior of 5FU/PGA composite, the current results have provided the possibility of utilizing melt processing as a tool to produce medical devices for successful drug delivery applications,