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박학열(Hak Youle Park),서준영(Jun Young Seo),송준백(June Baek Song),김태상(Tae Sang Kim),김익수(Ik Soo Kim) 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.10
Acardiac twinning affects 1 in 100 monozygotic twin pregnancies and 1 in 35,000 pregnancies overall. This condition is characterized by the absence or rudimentary development of fetal heart, and associated with various anomaly. The presence of an acardiac twin requires the normal (or pump) twin to provide circulation for itself, as well as the acardiac sibling. The acardiac malformations are uniformly fatal in the affected twin, and mortality in the co-twin is as high as 55%. The principal perinatal problems associated with acardiac twinning are pump-twin congestive heart failure, maternal hydramnios, and preterm delivery. We recently experienced a case of acardius anceps associated with a normal male infant, so present with a brief review of the literature.
박학열(Hak Youle Park),문교철(Kyo Cheol Mun) 대한소화기학회 2002 대한소화기학회지 Vol.39 No.4
Backgroud/Aims: Oxygen free radicals can be defined as oxygen molecules or molecular fragments that have an unpaired electron. They are formed in all living organisms during physiological and pathophysiological metabolism, and cause cell and tissue damages due to their high chemical reactivity. They can react with macromolecules including lipid, protein and DNA. Peroxidation of lipids exposed to oxygen free radicals is responsible for the damages of cells and tissues in vivo, which may cause cancer, inflammatory disease and liver disease. During the regeneration of the liver, there might be some alterations for metabolism of oxygen free radicals, which causes damage to regenerating liver. To know the degree of damage by oxygen free radicals in cell organelles of regenerating liver, hepatectomy was performed to the Sprgue-Dawley rats. Methods: From the regenerating liver obtained at day 3 after hepatectomy homogenate, mitochondria, microsome, cytosol, nuclei and plasma membrane were obtained as samples by sucrose linear density gradient centrifuger. Then, their malondialdehyde levels were measured by thiobarbituric acid assay. Results: The level of malondialdehyde level were increased in the homogenate, mitochondria, microsome and cytosol of the regenerating liver than in those of the original liver. Conclusions: These results suggest that mitochondria and microsome are susceptible to the oxygen free radicals in the regenerating liver. (Korean J Gastroenterol 2002;39:284-288)
박세관(Sea Kwan Park),박학열(Hak Youle Park),문교철(Kyo Cheol Mun),김여희(You Hee Kim),곽춘식(Chun Sik Kwak) 대한소화기학회 2002 대한소화기학회지 Vol.40 No.4
Background/Aims: To know the metabolism of oxygen free radicals in the regenerating liver, the 70% (median and left lateral lobes) partial hepatectomy was performed in the Sprague-Dawley rats. Methods: The original livers were obtained immediately after the partial hepatectomy, while the regenerating livers were obtained at 3 days after the partial hepatectomy. The levels of xanthine oxidase, superoxide anion, antioxidant enzymes, hydrogen peroxide, and malondialdehyde were measured. RT-PCR for superoxide dismutase was also performed. Results: Compared to the original livers, the regenerating liver showed higher levels of xanthine oxidase, superoxide dismutase, catalase, glutathione peroxidase superoxide production, and malondialdehyde and lower level of hydrogen peroxide. RT- PCR did not show any significant change. Conclusions: The results suggest that malondialdehyde level is increased by xanthine oxidase via the increased production of superoxide anion. Superoxide dismutase activity is induced by the increase of superoxide anion. The increase of catalase and glutathione peroxidase levels causes the depletion of hydrogen peroxide level in the regenerating liver. (Korean J Gastroenterol 2002; 40: 255-262)