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증례 : 신장 ; 신이식 환자에서 성공적으로 치료된 BK 바이러스 관련 출혈성 방광염
박시형 ( Sihyung Park ),이가희 ( Ga Hee Lee ),박봉수 ( Bong Soo Park ),진규복 ( Kubok Jin ),박진한 ( Jin Han Park ),강진두 ( Jin Du Kang ),김양욱 ( Yang Wook Kim ) 대한내과학회 2015 대한내과학회지 Vol.89 No.6
Hemorrhagic cystitis is defined as diffuse mucosal inflammation of the urinary bladder that presents with gross hematuria. A variety of factors, including chemotherapeutic agents, radiation therapy and infection, can cause hemorrhagic cystitis. Among them, BK virus-associated hemorrhagic cystitis is common in patients who have undergone stem cell transplantation but relatively rare in kidney transplantation patients. Here, we present the case of a kidney-transplant patient with BK virus-associated hemorrhagic cystitis and interstitial nephritis who was successfully treated with leflunomide and ciprofloxacin. (Korean J Med 2015;89:704-708)
증례 : 신장 ; 관상동맥 성형술 시행한 환자에서 Clopidogrel과 관련된 용혈성 요독증후군
박시형 ( Si Hyung Park ),박진한 ( Jin Han Park ),박상율 ( Sang Yool Park ),이은지 ( Eun Ji Lee ),전현수 ( Hyun Soo Jun ),김영훈 ( Yeong Hoon Kim ),김양욱 ( Yang Wook Kim ) 대한내과학회 2011 대한내과학회지 Vol.80 No.2S
Clopidogrel은 항혈소판제로 여러 임상영역에서 사용된다. 기존의 약제보다 부작용도 적어 안전하게 널리 쓸 수 있는 이 약제가 드물게는 이와 같은 심각한 합병증을 유발할 수 있다. 이에 우리는 이러한 합병증을 이해하고 주의 해야 한다. 저자들은 급성 관상동맥 증후군이 있었던 47세 남자 환자에서 이와 같은 합병증을 경험하였고, 약물 중단 및 치료적 혈장분리술 등으로 호전되었던 증례를 1예 경험하였기에 문헌고찰과 함께 보고하는 바이다. Thienopyridines are antiplatelet agents used in post-percutaneous coronary angioplasty patients and patients with acute coronary syndrome, stroke, and peripheral arterial disease. Ticlopidine has been shown to reduce the incidence of stent thrombosis, but it may also cause serious hematological side effects. Among the thienopyridines, clopidogrel is considered to be a safe alternative to ticlopidine because of its decreased incidence of hematological adverse effects. However, some hematological side effects can occur and may be fatal. In this case, a 47-year-old man complained of dyspnea and generalized edema. He had been taking clopidogrel after coronary angioplasty. His laboratory findings showed acute renal failure, microangiopathic hemolytic anemia, and thrombocytopenia, which were consistent with hemolytic uremic syndrome (HUS). After discontinuing clopidogrel and undergoing plasma exchange, he recovered fully. To our knowledge, this is the first reported case of clopidogrel-induced HUS in Korea. (Korean J Med 2011;80:S253-S257)
박시형 ( Park Si Hyeong ),김관수 ( Kim Gwan Su ) 한국응용생명화학회 2004 Applied Biological Chemistry (Appl Biol Chem) Vol.47 No.1
Two flavonoids were isolated from the aerial parts of Salicornia herbacea L. by column chromatopaphy. The structures of the flavonoid compound 1 and 2 were identified as quercetin 3-O-β-D-glucopyranoside and isorhamnetin 3-O-β-D-glucopyranoside, respectively. The antioxidant activity of compound 1 was similar to those of quercetin and rutin, and the activity of compound 2, which contained methoxyl group at flavonoid B-ring, was lower than that of compound 1. The two compounds 1 and 2 were the first to be reported in this plant.
박시형(Si Hyung Park),정효상(Hyo Sang Jung),유태열(Tae Yol Yoo),이성수(Seaung Soo Lee) 한국자동차공학회 2001 한국자동차공학회 춘 추계 학술대회 논문집 Vol.2001 No.5_2
Motorcycle industry, for its competitive position, depends on part design technology. This part design has a bulky amount of data and asks the accumulation of advanced technical skill and experience, and fragmentary technical application is not enough to get to the kernel of a problem.<br/> Therefore, the improvement of proper productivity - the starting point of engineering design and useful Design Methodology for products manufacturing are needed.<br/> Thus this paper is aimed to create a program that outputs dynamic characteristics of a vehicle when the data from fully understanding on motorcycle's brake system and induced fornmla for brake design are inputted.<br/>