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Streptozotocin으로 당뇨 유발 신생 흰쥐에서 Leucocyanidins의 투여가 혈당 및 혈액학적 지수에 미치는 영향
강주섭,박진희,바규신,김신희,지옥화,이정식,박송희,서희경,임수진 대한암예방학회 2007 Journal of cancer prevention Vol.12 No.1
To investigate the effect of leucocyanidins (LCN) in streptozotocin (STZ)-treated newborn diabetic rats, we evaluated the changes of body weight, fasting blood glucose level, oral glucose tolerance test (OGTT), insulin level and biochemical parameters after the administration of LCN in STZ-treated newborn rats. In 7 days of age rats were received single intraperitoneal injection of 60 mg/kg of STZ. Animals were divided into four groups; STZ-induced DM group; LCN (LL)-treated group (30 mg/kg, i.p), LCN (HL)-treated group (60 mg/kg, i.p) at 8 weeks after the single injection of STZ (60 mg/kg, i.p.), respectively during 4 weeks.; Normal control (NC) group received vehicle and saline. Mean body weight change of DM group was retarded greatly by STZ-exposure. While, body weights of LL and HL groups were increased. Fasting blood glucose levels of LL and HL groups were reduced about 19% or 27% by LCN injection. The insulin level did not differ after treatment with LCN in experimental rats. The results of OGTT was improved in HL group compared to DM group. In LL and HL groups, blood glucose, ALT and AST and BUN levels were attenuated compared to DM group. From the results, it was suggested that LCN had a tendency to decrease on STZ-induced toxicity in terms of monitoring the blood glucose in fasting, OGTT and some biochemical parameter of the rat. (Cancer Prev Res 12, 51-57, 2007) Key Words: Streptozotocin, Leucocyanidins, Blood glucose, OGTT, Diabetes
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