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국소 진행성 및 소수 먼 곳 전이가 있는 전립선암에서 수술적 치료의 근거
문경태(Kyong Tae Moon),유탁근(Tag Keun Yoo) 대한비뇨기종양학회 2016 대한비뇨기종양학회지 Vol.14 No.3
There is no clear consensus for the best treatment of men with locally advanced prostate cancer. As a first step, radiation therapy or primary hormone therapy or radical prostatectomy with extended pelvic lymph node dissection is used. But it seems impossible to have a good oncologic result with single treatment modality. Traditionally, external beam radiation therapy with adjuvant hormone therapy is most preferred treatment method in locally advanced prostate cancer and radical prostatectomy has not been routinely used because of high rates of margin positive and lymph node metastasis. But, recently published articles showed that surgery in multimodal setting is effective treatment modality and not inferior to radiation therapy in oncologic outcomes. Perioperative morbidities of surgery and incontinence rates are similar to surgery of organ confined diseases, and patients with primary radiotherapy seem to have high rate of lower urinary tract symptoms and radiation related complications compared with radical prostatectomy with adjuvant radiotherapy. There is still controversy in regard to performing surgery for locally advanced prostate cancer. We review the studies with surgery in locally advanced prostate cancer and compare with radiation therapy in multimodal setting, and review the studies with surgery in oligometastatic prostate cancer.
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최지웅 ( Jeewoong Choi ),박소영 ( So Young Park ),문경태 ( Kyong Tae Moon ),이원미 ( Won Mi Lee ),이병훈 ( Byoung-hoon Lee ),김상훈 ( Sang-hoon Kim ) 대한천식알레르기학회(구 대한알레르기학회) 2021 Allergy Asthma & Respiratory Disease Vol.9 No.1
Nonepisodic angioedema with eosinophilia (NEAE) is a rare disease characterized by nonrecurrent angioedema with eosinophilia and normal serum IgM levels occurring predominantly in an East Asian female population. A 49-year-old male patient visited our clinic due to swelling of both the scrotums and the lower extremities, and fever. He had history of nasal polyp, cephalosporin allergy, and asthma. He was diagnosed as having NEAE and was treated with systemic corticosteroid, then he was symptom-free for more than 8 months. He had been administered omalizumab for 3 months due to uncontrolled asthma prior to the onset of angioedema which had helped taper the oral corticosteroid, and this may be associated with presentation of NEAE. Here, we report a case of NEAE in a male patient which presented with constitutional symptoms such as fever and scrotal edema. (Allergy Asthma Respir Dis 2021;9:46-49)
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상부요로 요로상피암에서 Heat Shock Protein 27와 Cellular FLICE-like Inhibitory Protein의 발현
조정만(Jeong Man Cho),조희주(Hee Joo Cho),문경태(Kyong Tae Moon),민동석(Dong Suk Min),김은경(Eun Kyung Kim),김덕윤(Duk Yoon Kim),박재신(Jae Shin Park),유탁근(Tag Keun Yoo) 대한비뇨기종양학회 2011 대한비뇨기종양학회지 Vol.9 No.2
Purpose: We investigated the expressions of Heat shock protein 27 (HSP27) and Cellular FLICE-like inhibitory protein (c-FLIP) with urothelial carcinoma of the upper tract. Materials and Methods: The expressions of HSP27 and c-FLIP were quantified immunohistochemically form sixty one patients who underwent nephroureterectomy for urothelial carcinoma of the upper tract and 10 patient’s normal ureteral tissues who underwent nephrectomy. The overall percentage of cancer cells showing staining (0% to 100%) was indicated by visual scoring. Specimens were graded from 0 to +3 intensity representing the range of staining area, for which below 1% is 0 grade, 1-10% is+1 grade, 10-50% is +2 grade, over 50% is +3 grade. Results: HSP27 positive reaction was seen in 10 of 10 cases (100%) with a normal ureter, 59 of 61 cases (96.7%) with urothelial carcinoma of the upper tract. The mean HSP27 reaction scores were 2.67 with low grade, 2.27 with high grade (p=0.045). HSP27 expression was not statistically significant according to stage and lymph node metastasis. c-FLIP positive reaction was seen in 0 of 10 cases (0%) with normal ureter, 57 of 61 cases (93.4%) with urothelial carcinoma of the upper tract. c-FLIP expression was not statistically significant according to grade, stage and lymph node metastasis. Conclusions: This study suggests that the expression of HSP27 is reduced and the expression of c-FLIP is increased in patients with urothelial carcinoma of the upper tract. If these data are confirmed, HSP27 and c-FLIP may be usable as prognostic marker of urothelial carcinoma of the upper tract.
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세포독성 항암화학요법을 받을 수 없는 환자에서의 Estramustine Phosphate 단독요법
류재현(Jae Hyun Ryu),김상진(Sang Jin Kim),김윤범(Yun Beom Kim),정태영(Tae Young Jung),문경태(Kyong Tae Moon),조정만(Jeong Man Cho),유탁근(Tag Keun Yoo) 대한비뇨기종양학회 2020 대한비뇨기종양학회지 Vol.18 No.2
Purpose: To investigate whether estramustine phosphate (EMP) monotherapy is applicable to castration-resistant prostate cancer (CRPC) patients who cannot receive cytotoxic chemotherapy. Materials and Methods: This retrospective single-arm study was conducted in CRPC patients who had not experienced cytotoxic chemotherapy and received EMP monotherapy (560 mg/day) at 2 institutions from 2008 to 2017. We analyzed prostate-specific antigen (PSA) responses, overall survival, and adverse effects of EMP treatment. Results: A total of 28 patients were analyzed. A reduction in serum PSA was observed in 11 patients (39.3%). Seven cases (25.9%) achieved more than 25% reduction of PSA, and 5 of them (18.5%) experienced more than 50% reduction. Median overall survival was 23 months (interquartile range, 10-60 months). Multivariable analyses demonstrated that low level of PSA at diagnosis of CRPC and long duration of prior androgen deprivation therapy were independent favorable factors predicting long-term overall survival. Adverse effects were edema (n=2; grade 2), nausea/vomiting (n=1; grade 2), gynecomastia (n=1; grade 2), and dyspnea (n=1; grade 1). Neither thromboembolic event nor grade 3-5 toxicity was observed. There was no discontinuation caused by side effects of EMP. Conclusions: EMP monotherapy could be considered as a safe treatment option with some effectiveness for CRPC patients who did not undergo cytotoxic chemotherapy. EMP is not generally recommended anticancer drug in the current guidelines for CRPC, but EMP monotherapy is thought to have an alternative role when a standard treatment cannot be selected due to patient"s age, health condition, or comorbidity.
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문경태,문도성,신병식 서울産業大學校 1995 논문집 Vol.41 No.1
This paper propose the design and implementation of interpolation filter which interpolate subsampled data with the FPGA in HD-MAC decoder. Interpolation filter is FMH(FIR-Medain Hybrid) filter, hybrid filter composed of linear and nonliner filter, which has characteristics of good conservation of edge and good restoration of fine lines and robust to noise. Interpolator is implemented with FPGA of Actel company. It is proved that interpolator is well operated at 27MHz.
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