http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
리원연 ( Won Yeon Lee ) 대한결핵 및 호흡기학회 2009 Tuberculosis and Respiratory Diseases Vol.67 No.4
Interstitial lung disease (ILD) is a group of diseases characterized by pulmonary interstitial inflammation. Finally the inflammation results in pulmonary fibrosis and impairment of oxygen transportation. The causes of idiopathic interstitial pneumonia (IIP) are unknown. Diagnosis of IIP is not easy, especially distinguising between nonspecific interstitial pneumonia and usual interstitial pneumonia (UIP). First line treatments of IIP include corticosteroids and immune modulators, which have limited effect. Currently, several drugs are being researched to prevent and treat fibrosis. Newer drugs that may useful to treat pulmonary fibrosis include endothelin receptor antagonist, recombinant soluble TNF receptor antagonist, and cotrimoxazole. The causes of IIP are largely unknown, treatment is not specific, and prognosis is poor. Recent studies are underway to investigate the pathogenesis and treatment of IIP and pulmonary fibrosis. As the pathogenesis of IIP is elucidated, better treatments will emerge.
리원연 ( Won Yeon Lee ) 대한내과학회 2011 대한내과학회지 Vol.80 No.2
Critically ill patients requiring treatment in intensive care unit (ICU) are increasing recently. The patients treating in intensive care unit have various catheter, device, antibiotics treatment, and decreased immunity, and are prone to get complications from those. Some complications are clinically insignificant, but some complications may be fatal. The serious complications are including ventilator associated pneumonia that is one type of hospital acquired pneumonia, venous thromboembolism that is a major risk factor of pulmonary embolism, and stress related ulcer that make clinically significant gastrointestinal bleeding. Those complications prolong ICU stay period, increase morbidity and mortality, and cost. Therefore we should try to decrease incidence of those complications. The methods to decrease the complications in ICU are including education of facility staffs including physicians, nurses, students, and other staffs, and daily formal routine evaluation of patients in ICU. (Korean J Med 2011;80: 152-157)
리원연 ( Won Yeon Lee ) 대한결핵 및 호흡기학회 2011 Tuberculosis and Respiratory Diseases Vol.71 No.5
Occupational lung disease (OLD) is a group of lung diseases caused and/or aggravated by organic and inorganic inhaled dust, fumes, and mist. OLD can develop under various occupational situations. Therefore, occupational history should be considered when evaluating respiratory symptoms. Once OLD is developed, it may not be treated and may even progress after exposure to the causative agents has stopped. The best ways to treat OLD are prevention and early detection by controlling the working environment and conducting regular surveillance of workers. Common OLDs in Korea are coal worker`s pneumoconiosis, asbestos-related diseases, and occupational asthma. Recent aspects of these common OLDs in Korea will be described based on recently published studies.
성인 비아토피 호흡기알레르기 환자에서 혈청 총 IgE와 신체질량지수의 관계
이지호 ( Ji Ho Lee ),리원연 ( Won Yeon Lee ),용석중 ( Suk Joong Yong ),신계철 ( Kye Chul Shin ),이선녕 ( Shun Nyung Lee ),이석정 ( Seok Jeong Lee ),김종환 ( Chong Whan Kim ),정세현 ( Sae Hyun Jung ),정예령 ( Ye Ryung Jung ),김상하 대한천식알레르기학회 2011 천식 및 알레르기 Vol.31 No.4
Background: Serum total IgE levels are increased in some obese patients with nonatopic respiratory allergy. It has not yet been fully determined a significant relationship between total IgE and body mass index (BMI) in nonatopic patients. We sought to examine the relationship between total IgE and BMI in patients with nonatopic respiratory allergy. Methods: We retrospectively reviewed 468 patietns with nonatopic asthma or allergic rhinitis without sensitization to 33 aeroallerens out of the 1,596 patients wirh respiratory allergic diseases who visitied Wonju Christian Hospital between June 2005 and July 2007. Nonatopy was determined by negative skin prick test results for all of the aeroallergens. Patients with were excluded from the study total IgE levels of >500 IU/mL because such levels were more frequently associated with other causes. Results: There were 468 patients with nonatopy and total IgE levels of <500 IU/mL (169 males and 299 females). The mean total IgE levels were 41.0 IU/mL in female patients with underweight (BMI<18.5 kg/m2), 64.6 IU/mL in those with normal weight (18.5≤BMI<23 kg/m2), 78.9 IU/mL in those with overweight (23≤BMI<25 kg/m2), and 85.5 IU/mL in those with obesity (BMI≥25 kg/m2). The mean total IgE levels were significantly higher in female patients with obesity or overweight than in those without (83.4 versus 61.8 IU/mL, P=0.036). There were no significant difference in serum total IgE levels according to BMI in male patients. Conclusion: Obesity may be a contributor to increased total IgE levels in female patients with nonatopic respiratory allergy. (Korean J Asthma Allergy Clin Immunol 2011; 31:288-294)
이석정 ( Seok Jeong Lee ),리원연 ( Won Yeon Lee ),정순희 ( Soon Hee Jung ),권우철 ( Woo Cheol Kwon ),이선녕 ( Shun Nyung Lee ),이남석 ( Nam Seok Lee ),김상하 ( Sang Ha Kim ),신계철 ( Kye Chul Shin ),용석중 ( Seok Joong Yong ) 대한결핵 및 호흡기학회 2008 Tuberculosis and Respiratory Diseases Vol.65 No.6
We report on a case of a patient with laryngo-tracheobronchial amyloidosis who complained of cough, sputum, and hoarseness. A chest X-ray showed consolidation in the right middle lobe. A chest CT scan showed diffuse, irregular narrowing of the tracheobronchial tree and atelectasis of the right middle lobe, with calcification of bronchial wall. Bronchoscopic findings were multinodular submucosal thickening of the right vocal cord, and yellowish multinodular submucosal thickening from the lower trachea through both main bronchi, as well as the lingular division of the left upper lobe, the right middle lobe, and the right lower lobe. The right middle lobe bronchus was nearly obstructed. The diagnosis of amyloidosis was made by multiple bronchoscopic biopsies on the right vocal cord and both bronchi. Pathologic findings were characteristic apple-green birefringence under polarized microscopy with Congo-red stain. The patient had no evidence of systemic amyloidosis. The patient is under conservative symptomatic treatment. (Tuberc Respir Dis 2008;65:532-536)
호흡기 알레르기증상으로 강원도의 한 대학병원을 방문한 환자에서 흡입 알레르겐에 대한 감작률
이명규 ( Myoung Kyu Lee ),리원연 ( Won Yeon Lee ),용석중 ( Suk Joong Yong ),신계철 ( Kye Chul Shin ),이선녕 ( Shun Nyung Lee ),이석정 ( Seok Jeong Lee ),이지호 ( Ji Ho Lee ),정세현 ( Sae Hyun Jung ),정예령 ( Ye Ryung Jung ),김상하 대한천식알레르기학회 2011 천식 및 알레르기 Vol.31 No.1
Background: There are some differences in common inhalant allergens among regions in Korea. Gangwon region, including Wonju City, which has a lot of mountains is relatively less urbanized and industrialized. It is necessary to determine which inhalant allergens are common in this region. Objective: This study was conducted to observe the prevalence of sensitization to inhalant allergens in patients visiting a university hospital in Gangwon region and to evaluate the difference in sensitization rates to allergens from other regions in Korea. Method: Skin prick tests were performed with 33 common inhalant allergens on 1,596 patients with respiratory allergic symptoms from June 2005 through July 2007 at a university hospital. Result: The number of positive responders to more than 1 allergen was 609 (38.2%) of the 1,596 patients. The most common offending allergen was Dermatophagoides pteronyssinus (19.5%), followed by Dermatophagoides farinae (17.2%), Tyrophagus putrescentiae (10.1%), Trichophyton (9.5%), rabbit fur (7.8%), mugwort (7.4%), cockroach (6.5%) and orchard grass (4.9%). Conclusion: The most common offending allergen was found to be the house dust mite in Gangwon region. The sensitization rate to mugwort pollen is the highest among pollen allergens, followed by orchard grass pollen. (Korean J Asthma Allergy Clin Immunol 2011;31:27-32)
이선녕 ( Shun Nyung Lee ),이석정 ( Seok Jeong Lee ),노진규 ( Jin Kyu Noh ),이민수 ( Min Su Lee ),이남석 ( Nam Seok Lee ),이부길 ( Bu Ghil Lee ),리원연 ( Won Yeon Lee ),용석중 ( Suk Joong Yong ),신계철 ( Kye Chul Shin ),김상하 ( Sa 대한천식알레르기학회 2008 천식 및 알레르기 Vol.28 No.4
Occupational allergic rhinitis caused by rabbit fur has been reported in Korea. However, occupational asthma due to rabbit fur has not yet reported in Korea. We report a suspected case of allergic asthma caused by rabbit fur on occupational exposure. A 35-year-old male developed dyspnea, chest discomfort related to rabbit fur. He has been worked for a spinning factory. He presented with a history of allergic rhinitis and asthma. Peripheral blood eosinophil count was 690/mm3. Bronchodilator response was positive, the results of skin prick test were positive for house dust mite, cockroach and rabbit fur. The level of specific IgE for rabbit fur was 8.39 KU/L. The methacholine challenge test was positive (PC20 1.96 mg/mL). These findings suggest that the rabbit fur could induce occupational asthma. We could not perform bronchoprovacation test with rabbit fur due to patient`s refusal. He is in a well controlled state with the use of a combination of inhaled corticosteroid and long acting β2 agonist after the avoidance of rabbit fur. (Korean J Asthma Allergy Clin Immunol 2008;28:309-312)
들깨 볶는 작업에 의한 연기 흡입으로 발생한 직업성 천식
정세현 ( Sae Hyun Jung ),리원연 ( Won Yeon Lee ),용석중 ( Suk Joong Yong ),신계철 ( Kye Chul Shin ),김종환 ( Chong Whan Kim ),이지호 ( Ji Ho Lee ),정예령 ( Ye Ryung Jung ),김현식 ( Hyun Sik Kim ),유태선 ( Tae Sun Yu ),김상하 ( San 대한천식알레르기학회 2013 Allergy Asthma & Respiratory Disease Vol.1 No.1
Perilla is an Asian grain that consumed for food ingredient, oil crops, medicinal materials through the process of roasting. A 49-year-old male has been roasting grains for 10 years, who met with shortness of breath during the roasting perilla seeds, but not in other situations. Serum total immunoglobulin E (IgE) level, serum eosinophil count and skin prick test didn`t showed significant results. Methacholine bronchial provocation test was positive (PC20 0.31 mg/mL). Specific bronchial provocation test with inhaling smoke from roasting perilla seeds showed a dual asthmatic response. Measured peak expiratory flow rate on his work place showed the result of 37% decrease at the end of work and full recovery at 6 hours after the end of work. Skin prick test to row perilla showed positive response with late symptoms. We diagnosed that the patient had an occupational asthma caused by inhaling smoke from roasting perilla seeds with IgE mediated mechanism. (Allergy Asthma Respir Dis 1(1):90-93, 2013)