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Elevated plus - maze 를 이용한 신기환 , 보중익기탕 및 사물탕의 항불안 효과
류종훈(Jong Hoon Ryu),김민선(Min Sun Kim),황영선(Young Sun Hwang),육창수(Chang Soo Yook) 한국응용약물학회 2001 Biomolecules & Therapeutics(구 응용약물학회지) Vol.9 No.2
Shin-Ki-Hwan (Shen-Qi-Wan, SKH), Bo-Jung-Ik-Ki-Tang (Bu-Zhong-Yi-Qi-Tang, BJIKT), and Sa-Mul-Tang (Si-Wu-Tang, SMT) have been used for various kinds of deficiency syndromes, such as `yang`, `qi`, and `blood`, respectively. The objects of this study were to determine the effects of water extracts of three different kinds of traditional Chinese medicine (TCM), SKH, BJIKT, and SMT, on the anxiolytic activities in the elevated plus-maze test and to clarify the differences among `yang`, `qi`, and `blood`. The water extracts of SKH, BJIKT, and SMT were orally administered to male SD rats, at 1.0 g/kg for 10 days. All rats were subjected to behavioral tests for the anxiolytic activity at 10 days. SKH, for the benefiting `yang` agents, significantly increased the ratio of open arms entry to the total arms entry and time spent in the open arms (p<0.05), suggesting anxiolytic effect. However, both BJIKT and SMT decreased the ratio of open arms entry to the total arms entry and increased times spent in the closed arms (p<0.05). From these findings, it can be speculated that SKH only exhibits anxiolytic effect and that the different anxiolytic effects in the elevated plus-maze test may be come from the meanings of `yang`, `qi`, and `blood` in oriental diagnostics though the cases are restricted.
Elevated Plus-maze를 이용한 Phenylpropanoid의 항불안 효과
윤병훈(Byung Hoon Yoon),최지웅(Ji Woong Choi),정지욱(Ji Wook Jung),신진선(Jin Sun Shin),현성예(Seong Ye Hyeon),정재훈(Jae Hoon Cheong),류종훈(Jong Hoon Ryu),고광호(Kwang Ho Ko) 대한약학회 2005 약학회지 Vol.49 No.5
The purpose of this study was to characterize the putative anxiolytic-like effects of phenylpropanoids using the elevated plus maze (EPM) test in mice. Cinnamic acid, p-coumaric acid, caffeic acid and ferulic acid were orally administered to male ICR mice, 1 h before behavioral evaluation in an EPM, respectively. Control mice were treated with an equal volume of vehicle, and positive control mice diazepam(1 mg/kg). A single treatment with phenylpropanoids (at 8 mg/kg) significantly increased time-spent and arm entries into the open arms of the EPM., and decreased time-spent and arm entries into the closed arms of the EPM versus control (P〈 0.05). However, no changes in the locomotor activity and myorelaxant effect were seen in any group versus the saline control. These results suggest that phenylpropanoids may be an effective anxiolytic agent.
이용섭(Yong Sup Lee),류종훈(Jong Hoon Ryu),박동현(Dong Hyun Park),윤용돈(Yong Don Yun),남승옥(Seung Ok Nam) 大韓藥學會 2011 약학회지 Vol.55 No.6
Alzheimer's disease (AD), one of the most common forms of dementia, is a progressive neurodegenerative disorder symptomatically characterized by the decline in memory and cognitive abilities. To date, the successful therapeutic strategy to treat AD is to maintain the levels of acetylcholine (ACh) by inhibiting acetylcholinesterase (AChE) to lead five drugs in clinical use. In this study, several coumarin derivatives were designed based on the lead structure of scopoletin and evaluated for their AChE inhibitory activities.
동맥경화유발 토끼와 형질전환 마우스에서 산마늘 추출물의 항동맥경화 효과
김태균,김승희,강석연,정기경,최돈하,박용복,류종훈,한형미,Kim, Tae-Gyun,Kim, Seung-Hee,Kang, Soeg-Youn,Jung, Ki-Kyung,Choi, Don-Ha,Park, Yong-Bok,Ryu, Jong-Hoon,Han, Hyung-Mee 한국생약학회 2000 생약학회지 Vol.31 No.2
Atherosclerosis is emerging as one of the major causes of death in Korea as well as Western societies. In the present study; hypocholesterolemic and antiatherogenic effects of the ethanol extract of Allium victorialis Makino was investigated using the conventional rabbit and the cholesteryl ester transfer protein (CETP)-transgenic mouse model. Hypercholesterolemia was induced by feeding high cholesterol diet to the animals for 30 days and they were then fed with high cholesterol diet containing 0.5% of the A. victorialis extract for additional 30 (or 40) days. In the experiment using rabbits, treatment with the A. victorialis extract significantly decreased plasma total cholesterol, low density lipoprotein (LDL)-cholesterol, triglyceride levels and lipid peroxidation compared to those in the control group. Total cholesterol contents in the liver and the heart were also significantly decreased. Lipid staining of the aorta isolated from the rabbits showed that treatment with the A. victorialis extract decreased formation of atheromatous plaques on the intima of the aorta. In the experiment employing CETP transgenic mouse model, treatment with the A. victorialis extract decreased the levels of plasma total cholesterol and the tissue triglyceride levels in the heart. These results demonstrated that the ethanol extract of A. victorialis lowered serum cholesterol levels, tissue lipid contents and accumulation of cholesterol in the artery.
약물-건강기능식품 상호작용과 약물 장기 복용에 따른 영양소 결핍현상에 대한 고찰
강태진(Tae Jin Kang),김지연(Ji Yeon Kim),류종훈(Jong Hoon Ryu),김동학(Dong Hak Kim),이충재(Choong Jae Lee) 대한약학회 2020 약학회지 Vol.64 No.2
Drug-food interaction is defined as an interaction between a drug and nutritional elements. The interaction may increase or decrease the effectiveness and/or the adverse reaction of the drug or vice versa. The Failure to identify and properly manage drug-nutrient interactions can lead to serious consequences and this predisposes the patient to treatment failure. In the present review, we discussed the recent progress in the field of research on both the interaction between drug and health-functional food, especially in major chronic diseases such as cancer and diabetes mellitus and the mechanism of nutrient deficiency as the side effects of prescription drugs, in order to make us try to suggest the safe and efficacious pharmacotherapy through highlighting the issues surrounding drug-food interaction and the consequences of these interactions for human being.