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자궁경부상피내종양과 침윤성 편평상피암종의 혈관신생에서 비만세포와 혈관내피성장인자의 발현
제갈승주 ( Seung Joo Jekal ),이정아 ( Jung Ah Lee ),노종섭 ( Jong Sup Rho ) 대한임상검사과학회 2005 대한임상검사과학회지(KJCLS) Vol.37 No.3
To determine the correlation between mast cells(MCs) and neoangiogenesis in the growth and progression of cervical cancer, we investigated mast cell density(MCD), microvessel density(MVD) and the expression of vascular epithelial growth factor(VEGF) in cervical intraepithelial neoplasia and invasive suqamous cell carcinoma of the uterine cervix. Forty-five cervical intraepithelial neoplasia(CIN I, II and III), 15 microinvasive carcinomas, 15 invasive squamous cell carcinomas and 20 normal cervical epithelia were included in this study. MCs were stained with anti-c-Kit antibody and alcian blue, microvessels with anti-factor VIII antibody and VEGF with anti-VEGF antibody. The adjacent fields of both normal and neoplastic epithelium were used for counting MCs and microvessels. Computerized image analysis was used to evaluate MCD and MVD. MCD and MVD were the mean numbers per 1mm2 counted in 5-10 high and low power fields respectively. In both c-Kit and alcian blue stained sections, MCD progressively increased along the continuum from CIN I to invasive squamous cell carcinoma(p<0.001). MVD increased significantly with cervical neoplasia progression, from CIN to invasive squamous cell carcinoma (p<0.001). In double c-Kit and Factor VIII-stained sections, MCs were mainly present in the areas adjacent to newly formed blood vessels. However, there were no significant differences in MCD and MVD between normal epithelum and CIN I. A strong correlation was also observed between MCD and MVD. In double VEGF and alcian blue-stained sections, VEGF was expressed in only MCs. Strong VEGF-positive MCs were particularly abundant around the tumorous region. Our results suggest that MCs may upregulate neoangiogenesis by VGEF secretion in the development and progression of cervical neoplasia
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샤염화탄소 투여 쥐에서 아연이 간세포의 아포토시스와 TGF-ßl 분바에 미치는 영향
제갈승주 ( Seung Joo Jakal ),김은정 ( Eun Jung Kim ),최영자 ( Young Ja Choi ),곽효일 ( Hyo Il Kwak ),노종섭 ( Jong Sup Rho ),신용섭 ( Yong Sup Shin ),김진경 ( Jin Kyung Kim ) 대한임상검사과학회 2002 대한임상검사과학회지(KJCLS) Vol.34 No.2
Recently zinc has been known as a beneficial agent in the protection against hepatotoxicity and Its effect was supposed due to decreased hepatic cel1 apoptosis by the inhibition of endonuclease activity. Meanwhile, Transfonning growth factor-ßl (TGF-ßl) was considered an important regu1ator in the pathogenesis of early hepatic fibrosis. The aim of this study was to ascertain the effect of zinc on hepatic cell apoptosis and TGF-ß lsecretion in early hepatic fibrosis induced by carbon tetrachloride (CC4). Twenty male Wistar rats were divided into four groups: the control group, control + zinc treated group, CC14 treated group and CC4 +zinc treated group. All the rats were sacrified 8 days later for histological and biochemical assessments. The col1agen content in liver was measured after Masson’s trichrome staining, apoptosis was detected by terminal UDP-nick end labelling (TUNEL) staining and TGF-ßl was quantified by labelled streptavidin biotin (LSAB) immunostaining using a computerized image analysis system. TUNEL-positive cells (apoptotic cel1s) increased in rats with early hepatic fibrosis and oral zinc administration decreased the number of apoptotic cells in the CC14-treated rats. The zinc-mediated decrease of apoptosis in the liver was related to an increase of TGF-ßl positive cel1s and col1agen content. However, AST, ALT levels and the number of fatty changed hepatic cel1s as an index of hepatic cell damage increased in rats with early hepatic fibrosis and two indices decreased by zinc administration. These results suggest that apoptosis may be involved, together with necrosis, in the early hepatic fibrogenesis and was closely related to the increase of TGF-ß 1 secretion and collagen content. Therefore, zinc could play an important role in the inhibition of early hepatic fibrosis induced by CC4
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