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글루타메이트로 유도된 쥐 해마 HT22 세포의 산화적 손상에 대한 서양민들레 지상부의 뇌신경세포 보호활성
리빈,이동성,최현규,김경수,지혜영,노정미,김기모,김윤철,Li, Bin,Lee, Dong-Sung,Choi, Hyun-Gyu,Kim, Kyung-Su,Ji, Hye-Young,Rho, Jung-Mi,Kim, Ki-Mo,Kim, Youn-Chul 대한약학회 2011 약학회지 Vol.55 No.4
Glutamate-induced oxidative injury contributes to neuronal degeneration in many central nervous system (CNS) diseases, such as epilepsy and ischemia. Inducible heme oxygenase (HO)-1 acts against oxidants that are thought to play a role in the pathogenesis of these diseases. In the present study, we investigated the neuroprotective effects of the standard extracts of Taraxacum officinale Weber, one of the original plants of Taraxaci Herba, on glutamate-induced oxidative injury in mouse hippocampal HT22 cells. The standard EtOH extract of the aerial parts of T. officinale (NNMBS270) showed significant cytoprotective effects on glutamate-induced neurotoxicity and induced the expression of heme oxygenase (HO)-1 in the mouse hippocampal HT22 cells, while the roots' extract (NNMBS271) did not show neuroprotective effect. These results suggest that the extract of the aerial parts of T. officinale could be an effective candidate for the treatment of ROS-related neurological diseases.