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소라페닙 치료 간세포암 환자에서 발생한 드레스 증후군 1예
김동균 ( Dong Kyun Kim ),이성우 ( Sung Woo Lee ),남화성 ( Hwa Seong Nam ),전동섭 ( Dong Sub Jeon ),박나래 ( Na Rae Park ),남영희 ( Young Hee Nam ),이수걸 ( Soo Keol Lee ),백양현 ( Yang Hyun Baek ),한상영 ( Sang Young Han ),이성욱 대한소화기학회 2016 대한소화기학회지 Vol.67 No.6
Sorafenib is currently the only targeted therapy available for advanced stage hepatocellular carcinoma (HCC). Cutaneous adverse events associated with sorafenib treatment include hand-foot skin reaction, but there has been no report of drug reaction (or rash) with eosinophilia and systemic symptoms (DRESS) syndrome. Here, we report a case of 72-year-old man with HCC and alcoholic liver cirrhosis who developed skin eruptions, fever, eosinophilia, and deteriorated hepatic and renal function under sorafenib treatment. He has since successfully recovered with conservative care. (Korean J Gastroenterol 2016;67:337-340)
증례 : 소화기 ; 신우 종괴 형성과 췌장 침범을 동반한 IgG4 연관 경화성 질환 1예
김우재 ( Woo Jae Kim ),노명환 ( Myung Hwan Noh ),류충헌 ( Choong Heon Ryu ),한승희 ( Seung Hee Han ),남화성 ( Hwa Seong Nam ),한지은 ( Ji Eun Han ),홍숙희 ( Sook Hee Hong ) 대한내과학회 2014 대한내과학회지 Vol.87 No.6
IgG4-related sclerosing disease is a disease entity that has recently attracted attention, manifesting as a multiorgan disease characterized by high serum IgG4 levels, extensive IgG4-positive plasma cells and lymphocyte infiltration of the affected organs, with the pancreas (autoimmune pancreatitis) and kidney as representative targets. In cases of renal involvement, parenchymal lesions are predominant, such as renal cortical lesions or diffuse renal enlargement. However, mass-like lesions involving the renal pelvis are very rare, and mass forming or pelvic involvement types should be distinguished from lymphomas, metastatic cancers and other genitourinary malignancies to avoid unnecessary surgery. Herein, we report a case of IgG4-related sclerosing disease involving the kidney as an unusual involvement pattern presenting as a mass-like lesion with pelvic and perirenal involvement. (Korean J Med 2014,87:710-715)